7WET

Crystal structure of Peroxiredoxin I in complex with the inhibitor Cela

Summary for 7WET

• Entry DOI: 10.2210/pdb7wet/pdb
• Descriptor: Peroxiredoxin-1, (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid (3 entities in total)
• Functional Keywords: complex, inhibitor, peroxiredoxin, oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 39575.35

Authors

Zhang, H.,Luo, C. (deposition date: 2021-12-24, release date: 2022-12-28, Last modification date: 2023-11-29)

• Primary citation: Xu, H.,Zhao, H.,Ding, C.,Jiang, D.,Zhao, Z.,Li, Y.,Ding, X.,Gao, J.,Zhou, H.,Luo, C.,Chen, G.,Zhang, A.,Xu, Y.,Zhang, H.; Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1.; Signal Transduct Target Ther, 8:51-51, 2023; PubMed: 36732502; DOI: 10.1038/s41392-022-01231-4

Experimental method

X-RAY DIFFRACTION (1.76 Å)