8WX0
 
 | | PNPase of M.tuberculosis with its RNA substrate | | 分子名称: | Bifunctional guanosine pentaphosphate synthetase/polyribonucleotide nucleotidyltransferase, RNA (24-mer) | | 著者 | Wang, N, Sheng, Y.N. | | 登録日 | 2023-10-27 | | 公開日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Cryo-EM structures of Mycobacterium tuberculosis polynucleotide phosphorylase suggest a potential mechanism for its RNA substrate degradation.
Arch.Biochem.Biophys., 754, 2024
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8WXF
 | | PNPase of Mycobacterium tuberculosis | | 分子名称: | Bifunctional guanosine pentaphosphate synthetase/polyribonucleotide nucleotidyltransferase | | 著者 | Wang, N, Sheng, Y.N, Liu, Y.T. | | 登録日 | 2023-10-29 | | 公開日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Cryo-EM structures of Mycobacterium tuberculosis polynucleotide phosphorylase suggest a potential mechanism for its RNA substrate degradation.
Arch.Biochem.Biophys., 754, 2024
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6AGI
 | | Crystal Structure of EFHA2 in Ca-binding State | | 分子名称: | CALCIUM ION, Calcium uptake protein 3, mitochondrial, ... | | 著者 | Yangfei, X, Xue, Y, Yuequan, S. | | 登録日 | 2018-08-11 | | 公開日 | 2019-01-23 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.799 Å) | | 主引用文献 | Dimerization of MICU Proteins Controls Ca2+Influx through the Mitochondrial Ca2+Uniporter.
Cell Rep, 26, 2019
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6R5W
 | | Crystal structure of the receptor binding protein (gp15) of Listeria phage PSA | | 分子名称: | ACETATE ION, CADMIUM ION, Gp15 protein, ... | | 著者 | Dunne, M, Ernst, P, Pluckthun, A, Loessner, M.J, Kilcher, S. | | 登録日 | 2019-03-25 | | 公開日 | 2019-10-30 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Reprogramming Bacteriophage Host Range through Structure-Guided Design of Chimeric Receptor Binding Proteins.
Cell Rep, 29, 2019
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7Y1Y
 | | S-ECD (Omicron BA.2) in complex with PD of ACE2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ... | | 著者 | Li, Y.N, Shen, Y.P, Zhang, Y.Y, Yan, R.H. | | 登録日 | 2022-06-09 | | 公開日 | 2023-07-12 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural Basis for the Enhanced Infectivity and Immune Evasion of Omicron Subvariants.
Viruses, 15, 2023
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7Y1Z
 | | S-ECD (Omicron BA.3) in complex with three PD of ACE2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ... | | 著者 | Li, Y.N, Shen, Y.P, Zhang, Y.Y, Yan, R.H. | | 登録日 | 2022-06-09 | | 公開日 | 2023-07-12 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural Basis for the Enhanced Infectivity and Immune Evasion of Omicron Subvariants.
Viruses, 15, 2023
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7Y20
 | | S-ECD (Omicron BA.3) in complex with two PD of ACE2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ... | | 著者 | Li, Y.N, Shen, Y.P, Zhang, Y.Y, Yan, R.H. | | 登録日 | 2022-06-09 | | 公開日 | 2023-08-09 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structural Basis for the Enhanced Infectivity and Immune Evasion of Omicron Subvariants.
Viruses, 15, 2023
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7Y21
 | | S-ECD (Omicron BA.5) in complex with PD of ACE2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ... | | 著者 | Li, Y.N, Shen, Y.P, Zhang, Y.Y, Yan, R.H. | | 登録日 | 2022-06-09 | | 公開日 | 2023-08-09 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural Basis for the Enhanced Infectivity and Immune Evasion of Omicron Subvariants.
Viruses, 15, 2023
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6AGH
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6AGJ
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5UEY
 | | BRD4_BD2_A-1412838 | | 分子名称: | 5-[2-(2,4-difluorophenoxy)-5-{[ethyl(dihydroxy)-lambda~4~-sulfanyl]amino}phenyl]-4-ethoxy-1-methylpyridin-2(1H)-one, Bromodomain-containing protein 4 | | 著者 | Park, C.H. | | 登録日 | 2017-01-03 | | 公開日 | 2017-05-10 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | | 主引用文献 | Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors.
J. Med. Chem., 60, 2017
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5UEX
 | | BRD4_BD2_A-1497627 | | 分子名称: | 17-{[ethyl(dihydroxy)-lambda~4~-sulfanyl]amino}-11,13-difluoro-2-methyl-6,7,8,9-tetrahydrodibenzo[4,5:7,8][1,6]dioxacyclododecino[3,2-c]pyridin-3(2H)-one, Bromodomain-containing protein 4 | | 著者 | Park, C.H. | | 登録日 | 2017-01-03 | | 公開日 | 2017-05-10 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | | 主引用文献 | Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors.
J. Med. Chem., 60, 2017
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5UEU
 | | BRD4_BD2_A-1107604 | | 分子名称: | Bromodomain-containing protein 4, methyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate | | 著者 | Park, C.H. | | 登録日 | 2017-01-03 | | 公開日 | 2017-05-10 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors.
J. Med. Chem., 60, 2017
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5UF0
 | | BRD4_BD2-A-35165 | | 分子名称: | 2-methyl-5-(methylamino)-6-phenylpyridazin-3(2H)-one, Bromodomain-containing protein 4 | | 著者 | Park, C.H. | | 登録日 | 2017-01-03 | | 公開日 | 2017-06-28 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors.
J. Med. Chem., 60, 2017
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5UEZ
 | | BRD4_BD2_A-1342843 | | 分子名称: | 5-methoxy-2-methyl-6-(2-phenoxyphenyl)pyridazin-3(2H)-one, Bromodomain-containing protein 4 | | 著者 | Park, C.H. | | 登録日 | 2017-01-03 | | 公開日 | 2017-05-10 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | | 主引用文献 | Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors.
J. Med. Chem., 60, 2017
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5UE8
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7X83
 | | Cryo-EM structure of the TMEM106B fibril from normal elder | | 分子名称: | Transmembrane protein 106B | | 著者 | Xia, W.C, Zhao, Q.Y, Fan, Y, Sun, Y.P, Tao, Y.Q, Liu, C. | | 登録日 | 2022-03-11 | | 公開日 | 2022-06-15 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Generic amyloid fibrillation of TMEM106B in patient with Parkinson's disease dementia and normal elders.
Cell Res., 32, 2022
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7X84
 | | Cryo-EM structure of the TMEM106B fibril from Parkinson's disease dementia | | 分子名称: | Transmembrane protein 106B | | 著者 | Zhao, Q.Y, Xia, W.C, Fan, Y, Sun, Y.P, Tao, Y.Q, Liu, C. | | 登録日 | 2022-03-11 | | 公開日 | 2022-06-15 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Generic amyloid fibrillation of TMEM106B in patient with Parkinson's disease dementia and normal elders.
Cell Res., 32, 2022
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8XB0
 | | Structure-Based Design and Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with SAM and Compound 292 | | 分子名称: | 1,2-ETHANEDIOL, 7-chloranyl-5-(2-cyclopropylpyridin-3-yl)-8-fluoranyl-2-methyl-pyrazolo[3,4-c]quinolin-4-one, CHLORIDE ION, ... | | 著者 | Tong, S.L, Zhang, G.P. | | 登録日 | 2023-12-05 | | 公開日 | 2024-06-26 | | 実験手法 | X-RAY DIFFRACTION (1.12 Å) | | 主引用文献 | Structure-Based Design and Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with High Selectivity, Brain Penetration, and In Vivo Efficacy.
J.Med.Chem., 67, 2024
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8XAR
 | | Structure-Based Design and Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with SAM and Compound 54 | | 分子名称: | 1,2-ETHANEDIOL, 7-chloranyl-2-ethyl-5-pyridin-3-yl-pyrazolo[3,4-c]quinolin-4-one, CHLORIDE ION, ... | | 著者 | Zheng, J.Y, Zhang, G.P, Li, J.J, Tong, S.L. | | 登録日 | 2023-12-05 | | 公開日 | 2024-06-26 | | 実験手法 | X-RAY DIFFRACTION (1.19 Å) | | 主引用文献 | Structure-Based Design and Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with High Selectivity, Brain Penetration, and In Vivo Efficacy.
J.Med.Chem., 67, 2024
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7DD7
 | | Structure of Calcium-Sensing Receptor in complex with Evocalcet | | 分子名称: | 2-[4-[(3S)-3-[[(1R)-1-naphthalen-1-ylethyl]amino]pyrrolidin-1-yl]phenyl]ethanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Wen, T.L, Yang, X, Shen, Y.Q. | | 登録日 | 2020-10-27 | | 公開日 | 2021-06-16 | | 最終更新日 | 2021-06-23 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural basis for activation and allosteric modulation of full-length calcium-sensing receptor.
Sci Adv, 7, 2021
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7DD5
 | | Structure of Calcium-Sensing Receptor in complex with NPS-2143 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-chloro-6-[(2R)-2-hydroxy-3-{[2-methyl-1-(naphthalen-2-yl)propan-2-yl]amino}propoxy]benzonitrile, ... | | 著者 | Wen, T.L, Yang, X, Shen, Y.Q. | | 登録日 | 2020-10-27 | | 公開日 | 2021-06-16 | | 最終更新日 | 2021-06-23 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural basis for activation and allosteric modulation of full-length calcium-sensing receptor.
Sci Adv, 7, 2021
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7DD6
 | | Structure of Ca2+/L-Trp-bonnd Calcium-Sensing Receptor in active state | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Wen, T.L, Yang, X, Shen, Y.Q. | | 登録日 | 2020-10-27 | | 公開日 | 2021-06-16 | | 最終更新日 | 2021-06-23 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural basis for activation and allosteric modulation of full-length calcium-sensing receptor.
Sci Adv, 7, 2021
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5WYD
 | | Structural of Pseudomonas aeruginosa DspI | | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ISOPROPYL ALCOHOL, ... | | 著者 | Liu, L, Peng, C, Li, T, Li, C, He, L, Song, Y, Zhu, Y, Shen, Y, Bao, R. | | 登録日 | 2017-01-12 | | 公開日 | 2018-01-31 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.101 Å) | | 主引用文献 | Structural and functional studies on Pseudomonas aeruginosa DspI: implications for its role in DSF biosynthesis.
Sci Rep, 8, 2018
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7YIV
 | | The Crystal Structure of Human Tissue Nonspecific Alkaline Phosphatase (ALPL) at Basic pH | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alkaline phosphatase, ... | | 著者 | Cao, Y, Qin, A, Yu, Y.T, Yao, D.Q, Zhang, Q, Rao, B, Xia, Y, Lu, Y. | | 登録日 | 2022-07-18 | | 公開日 | 2023-07-19 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.18 Å) | | 主引用文献 | The structural pathology for hypophosphatasia caused by malfunctional tissue non-specific alkaline phosphatase.
Nat Commun, 14, 2023
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