7YIV

The Crystal Structure of Human Tissue Nonspecific Alkaline Phosphatase (ALPL) at Basic pH

Summary for 7YIV

• Entry DOI: 10.2210/pdb7yiv/pdb
• Descriptor: Alkaline phosphatase, tissue-nonspecific isozyme, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: alkaline phosphatase, bone mineralization, catalytic network, hypophosphatasia, structural biology, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 8
• Total formula weight: 468052.86

Authors

Cao, Y.,Qin, A.,Yu, Y.T.,Yao, D.Q.,Zhang, Q.,Rao, B.,Xia, Y.,Lu, Y. (deposition date: 2022-07-18, release date: 2023-07-19, Last modification date: 2023-11-29)

• Primary citation: Yu, Y.,Rong, K.,Yao, D.,Zhang, Q.,Cao, X.,Rao, B.,Xia, Y.,Lu, Y.,Shen, Y.,Yao, Y.,Xu, H.,Ma, P.,Cao, Y.,Qin, A.; The structural pathology for hypophosphatasia caused by malfunctional tissue non-specific alkaline phosphatase.; Nat Commun, 14:4048-4048, 2023; PubMed: 37422472; DOI: 10.1038/s41467-023-39833-3

Experimental method

X-RAY DIFFRACTION (3.18 Å)