1I4E
 
 | | CRYSTAL STRUCTURE OF THE CASPASE-8/P35 COMPLEX | | 分子名称: | Caspase-8, Early 35 kDa protein | | 著者 | Xu, G, Cirilli, M, Huang, Y, Rich, R.L, Myszka, D.G, Wu, H. | | 登録日 | 2001-02-20 | | 公開日 | 2001-03-28 | | 最終更新日 | 2013-09-25 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Covalent inhibition revealed by the crystal structure of the caspase-8/p35 complex.
Nature, 410, 2001
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6JOP
 | | Crystal structures of phage NrS-1 N300-dNTPs-Mg2+ complex provide molecular mechanisms for substrate specificity | | 分子名称: | MAGNESIUM ION, Primase, THYMIDINE-5'-TRIPHOSPHATE | | 著者 | Guo, H.J, Li, M.J, Wu, H, Yu, F, He, J.H. | | 登録日 | 2019-03-22 | | 公開日 | 2019-06-26 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.353 Å) | | 主引用文献 | Crystal structures of phage NrS-1 N300-dNTPs-Mg2+complex provide molecular mechanisms for substrate specificity.
Biochem.Biophys.Res.Commun., 515, 2019
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1I4O
 | | CRYSTAL STRUCTURE OF THE XIAP/CASPASE-7 COMPLEX | | 分子名称: | BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 4, CASPASE-7 | | 著者 | Huang, Y, Park, Y.C, Rich, R.L, Segal, D, Myszka, D.G, Wu, H. | | 登録日 | 2001-02-22 | | 公開日 | 2001-03-21 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain.
Cell(Cambridge,Mass.), 104, 2001
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2BBR
 | | Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and vFLIP Inhibition | | 分子名称: | AZIDE ION, Viral CASP8 and FADD-like apoptosis regulator | | 著者 | Yang, J.K, Wang, L, Zheng, L, Wan, F, Ahmed, M, Lenardo, M.J, Wu, H. | | 登録日 | 2005-10-17 | | 公開日 | 2006-02-14 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition.
Mol.Cell, 20, 2005
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2KBJ
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4JLG
 | | SETD7 in complex with inhibitor (R)-PFI-2 and S-adenosyl-methionine | | 分子名称: | 8-fluoro-N-{(2R)-1-oxo-1-(pyrrolidin-1-yl)-3-[3-(trifluoromethyl)phenyl]propan-2-yl}-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide, Histone-lysine N-methyltransferase SETD7, S-ADENOSYLMETHIONINE, ... | | 著者 | Dong, A, Wu, H, Zeng, H, El Bakkouri, M, Barsyte, D, Vedadi, M, Tatlock, J, Owen, D, Bunnage, M, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC) | | 登録日 | 2013-03-12 | | 公開日 | 2013-04-17 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.896 Å) | | 主引用文献 | (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.
Proc.Natl.Acad.Sci.USA, 111, 2014
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1Z4R
 | | Human GCN5 Acetyltransferase | | 分子名称: | ACETYL COENZYME *A, General control of amino acid synthesis protein 5-like 2 | | 著者 | Dong, A, Bernstein, G, Schuetz, A, Antoshenko, T, Wu, H, Loppnau, P, Sundstrom, M, Arrowsmith, C, Edwards, A, Bochkarev, A, Plotnikov, A, Structural Genomics Consortium (SGC) | | 登録日 | 2005-03-16 | | 公開日 | 2005-03-29 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | Crystal structure of a binary complex between human GCN5 histone acetyltransferase domain and acetyl coenzyme A
Proteins, 68, 2007
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2BBZ
 | | Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and vFLIP Inhibition | | 分子名称: | Viral CASP8 and FADD-like apoptosis regulator | | 著者 | Yang, J.K, Wang, L, Zheng, L, Wan, F, Ahmed, M, Lenardo, M.J, Wu, H. | | 登録日 | 2005-10-18 | | 公開日 | 2006-02-14 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | | 主引用文献 | Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition.
Mol.Cell, 20, 2005
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3RHZ
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3M0D
 | | Crystal structure of the TRAF1:TRAF2:cIAP2 complex | | 分子名称: | Baculoviral IAP repeat-containing protein 3, TNF receptor-associated factor 1, TNF receptor-associated factor 2, ... | | 著者 | Kabaleeswaran, V, Wu, H. | | 登録日 | 2010-03-02 | | 公開日 | 2010-04-28 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation.
Mol.Cell, 38, 2010
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9CSY
 | | SARS-CoV-2 papain-like protease (PLpro) bound to PF-07957472 | | 分子名称: | 2-methyl-5-(4-methylpiperazin-1-yl)-N-{1-[(2P)-2-(1-methyl-1H-pyrazol-4-yl)quinolin-4-yl]cyclopropyl}benzamide, Papain-like protease, ZINC ION, ... | | 著者 | Mashalidis, E.H, Chang, J.S, Wu, H, Garnsey, M. | | 登録日 | 2024-07-24 | | 公開日 | 2024-10-02 | | 実験手法 | X-RAY DIFFRACTION (2.595 Å) | | 主引用文献 | Discovery of SARS-CoV-2 papain-like protease (PL pro ) inhibitors with efficacy in a murine infection model.
Sci Adv, 10, 2024
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4HEB
 | | The Crystal structure of Maf protein of Bacillus subtilis | | 分子名称: | Septum formation protein Maf, UNKNOWN ATOM OR ION | | 著者 | Dong, A, Dombrovski, L, Brown, G, Flick, R, Tchigvintsev, D, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Iakounine, A, Min, J, Wu, H, Structural Genomics Consortium (SGC) | | 登録日 | 2012-10-03 | | 公開日 | 2012-10-24 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Biochemical and structural studies of conserved maf proteins revealed nucleotide pyrophosphatases with a preference for modified nucleotides.
Chem.Biol., 20, 2013
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3IHX
 | | Methyltransferase domain of human PR domain-containing protein 10 | | 分子名称: | PR domain zinc finger protein 10 | | 著者 | Amaya, M.F, Dombrovski, L, Ni, S, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Botchkarev, A, Min, J, Plotnikov, A.N, Wu, H, Structural Genomics Consortium (SGC) | | 登録日 | 2009-07-31 | | 公開日 | 2009-08-18 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Methyltransferase domain of human PR domain-containing protein 10
To be Published
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3KNV
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3PAR
 | | Surfactant Protein-A neck and carbohydrate recognition domain (NCRD) in the absence of ligand | | 分子名称: | CALCIUM ION, Pulmonary surfactant-associated protein A, SULFATE ION | | 著者 | Shang, F, Rynkiewicz, M.J, McCormack, F.X, Wu, H, Cafarella, T.M, Head, J, Seaton, B.A. | | 登録日 | 2010-10-19 | | 公開日 | 2010-11-03 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystallographic complexes of surfactant protein A and carbohydrates reveal ligand-induced conformational change.
J.Biol.Chem., 286, 2011
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3OQ9
 | | Structure of the FAS/FADD death domain assembly | | 分子名称: | Protein FADD, Tumor necrosis factor receptor superfamily member 6 | | 著者 | Kabaleeswaran, V, Wu, H. | | 登録日 | 2010-09-02 | | 公開日 | 2010-10-13 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (6.8 Å) | | 主引用文献 | The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations.
Nat.Struct.Mol.Biol., 17, 2010
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4LEC
 | | Human Methyltransferase-Like Protein 21A | | 分子名称: | Protein-lysine methyltransferase METTL21A, S-ADENOSYL-L-HOMOCYSTEINE, UNKNOWN ATOM OR ION | | 著者 | Dong, A, Zeng, H, Fenner, M, Wernimont, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Wu, H, Structural Genomics Consortium (SGC) | | 登録日 | 2013-06-25 | | 公開日 | 2013-07-17 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | The Crystal Structure of Human Methyltransferase-Like Protein 21A in Complex with SAH
To be Published
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3PAK
 | | Crystal Structure of Rat Surfactant Protein A neck and carbohydrate recognition domain (NCRD) complexed with Mannose | | 分子名称: | CALCIUM ION, Pulmonary surfactant-associated protein A, SODIUM ION, ... | | 著者 | Shang, F, Rynkiewicz, M.J, McCormack, F.X, Wu, H, Cafarella, T.M, Head, J, Seaton, B.A. | | 登録日 | 2010-10-19 | | 公開日 | 2010-11-03 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystallographic complexes of surfactant protein A and carbohydrates reveal ligand-induced conformational change.
J.Biol.Chem., 286, 2011
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4LG1
 | | Human Methyltransferase-Like Protein 21D | | 分子名称: | 1,2-ETHANEDIOL, Protein-lysine methyltransferase METTL21D, S-ADENOSYLMETHIONINE, ... | | 著者 | Dong, A, Zeng, H, Fenner, M, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Wu, H, Structural Genomics Consortium (SGC) | | 登録日 | 2013-06-27 | | 公開日 | 2013-07-17 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The Crystal Structure of Human Methyltransferase-Like Protein 21D in Complex with SAM
To be Published
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3PAQ
 | | Surfactant Protein A neck and carbohydrate recognition domain (NCRD) complexed with alpha-methylmannose | | 分子名称: | CALCIUM ION, Pulmonary surfactant-associated protein A, SODIUM ION, ... | | 著者 | Shang, F, Rynkiewicz, M.J, McCormack, F.X, Wu, H, Cafarella, T.M, Head, J, Seaton, B.A. | | 登録日 | 2010-10-19 | | 公開日 | 2010-11-03 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystallographic complexes of surfactant protein A and carbohydrates reveal ligand-induced conformational change.
J.Biol.Chem., 286, 2011
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3M06
 | | Crystal Structure of TRAF2 | | 分子名称: | TNF receptor-associated factor 2 | | 著者 | Kabaleeswaran, V, Wu, H. | | 登録日 | 2010-03-02 | | 公開日 | 2010-04-28 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | | 主引用文献 | Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation.
Mol.Cell, 38, 2010
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8GCD
 | | Full length Integrin AlphaIIbBeta3 in inactive state | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Huo, T, Wu, H, Wang, Z. | | 登録日 | 2023-03-01 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | | 主引用文献 | Full-length alpha IIb beta 3 cryo-EM structure reveals intact integrin initiate-activation intrinsic architecture.
Structure, 32, 2024
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8GCE
 | | The Extracellular Domain of Integrin AlphaIIbBeta3 in Intermediate State | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Huo, T, Wu, H, Wang, Z. | | 登録日 | 2023-03-01 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | | 主引用文献 | Full-length alpha IIb beta 3 cryo-EM structure reveals intact integrin initiate-activation intrinsic architecture.
Structure, 32, 2024
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3J63
 | | Unified assembly mechanism of ASC-dependent inflammasomes | | 分子名称: | Apoptosis-associated speck-like protein containing a CARD | | 著者 | Lu, A, Magupalli, V.G, Ruan, J, Yin, Q, Atianand, M.K, Vos, M, Schroder, G.F, Fitzgerald, K.A, Wu, H, Egelman, E.H. | | 登録日 | 2013-12-05 | | 公開日 | 2014-03-26 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes.
Cell(Cambridge,Mass.), 156, 2014
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3PBF
 | | Surfactant Protein-A neck and carbohydrate recognition domain (NCRD) complexed with glycerol | | 分子名称: | CALCIUM ION, GLYCEROL, Pulmonary surfactant-associated protein A | | 著者 | Shang, F, Rynkiewicz, M.J, McCormack, F.X, Wu, H, Cafarella, T.M, Head, J, Seaton, B.A. | | 登録日 | 2010-10-20 | | 公開日 | 2010-11-03 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystallographic complexes of surfactant protein A and carbohydrates reveal ligand-induced conformational change.
J.Biol.Chem., 286, 2011
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