5W2E
| HCV NS5B RNA-dependent RNA polymerase in complex with non-nucleoside inhibitor MK-8876 | 分子名称: | 2-(4-fluorophenyl)-5-(11-fluoro-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)-N-methyl-6-[methyl(methylsulfonyl)amino]-1-benzofuran-3-carboxamide, Genome polyprotein | 著者 | Lesburg, C.A, Ummat, A. | 登録日 | 2017-06-06 | 公開日 | 2017-08-16 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Development of a New Structural Class of Broadly Acting HCV Non-Nucleoside Inhibitors Leading to the Discovery of MK-8876. ChemMedChem, 12, 2017
|
|
6XZB
| E. coli 70S ribosome in complex with dirithromycin, fMet-Phe-tRNA(Phe) and deacylated tRNA(iMet) (focused classification). | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Pichkur, E.B, Polikanov, Y.S, Myasnikov, A.G, Konevega, A.L. | 登録日 | 2020-02-03 | 公開日 | 2020-11-04 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.54 Å) | 主引用文献 | Insights into the improved macrolide inhibitory activity from the high-resolution cryo-EM structure of dirithromycin bound to the E. coli 70S ribosome. Rna, 26, 2020
|
|
6TRI
| CI-MOR repressor-antirepressor complex of the temperate bacteriophage TP901-1 from Lactococcus lactis | 分子名称: | CI, MOR, SULFATE ION | 著者 | Rasmussen, K.K, Blackledge, M, Herrmann, T, Jensen, M.R, Lo Leggio, L. | 登録日 | 2019-12-18 | 公開日 | 2020-08-19 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.277 Å) | 主引用文献 | Revealing the mechanism of repressor inactivation during switching of a temperate bacteriophage. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
8SZY
| |
7S7I
| |
6V9Z
| |
7SU0
| Crystal structure of an acidic pH-selective Ipilimumab variant Ipi.105 in complex with CTLA-4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CITRATE ANION, Cytotoxic T-lymphocyte protein 4, ... | 著者 | Lee, P.S, Chau, B, Strop, P. | 登録日 | 2021-11-15 | 公開日 | 2022-03-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | Improved therapeutic index of an acidic pH-selective antibody. Mabs, 14, 2022
|
|
7SU1
| Crystal structure of an acidic pH-selective Ipilimumab variant Ipi.106 in complex with CTLA-4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytotoxic T-lymphocyte protein 4, Fab heavy chain, ... | 著者 | Lee, P.S, Chau, B, Strop, P. | 登録日 | 2021-11-15 | 公開日 | 2022-03-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | 主引用文献 | Improved therapeutic index of an acidic pH-selective antibody. Mabs, 14, 2022
|
|
6TO6
| Solution structure of the modulator of repression (MOR) of the temperate bacteriophage TP901-1 from Lactococcus lactis | 分子名称: | MOR | 著者 | Rasmussen, K.K, Blackledge, M, Herrmann, T, Lo Leggio, L, Jensen, M.R. | 登録日 | 2019-12-11 | 公開日 | 2020-08-19 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | Revealing the mechanism of repressor inactivation during switching of a temperate bacteriophage. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
6V0Z
| Structure of ALDH7A1 mutant R441C complexed with NAD | 分子名称: | 1,2-ETHANEDIOL, Alpha-aminoadipic semialdehyde dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Korasick, D.A, Tanner, J.J. | 登録日 | 2019-11-19 | 公開日 | 2020-11-25 | 最終更新日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Biochemical, structural, and computational analyses of two new clinically identified missense mutations of ALDH7A1. Chem.Biol.Interact., 2024
|
|
1F9B
| MELANIN PROTEIN INTERACTION: X-RAY STRUCTURE OF THE COMPLEX OF MARE LACTOFERRIN WITH MELANIN MONOMERS | 分子名称: | 3H-INDOLE-5,6-DIOL, BICARBONATE ION, FE (III) ION, ... | 著者 | Kumar, S, Singh, T.P, Sharma, A.K, Singh, N, Raman, G. | 登録日 | 2000-07-10 | 公開日 | 2001-02-10 | 最終更新日 | 2018-01-31 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Lactoferrin-melanin interaction and its possible implications in melanin polymerization: crystal structure of the complex formed between mare lactoferrin and melanin monomers at 2.7-A resolution. Proteins, 45, 2001
|
|
1JN3
| |
2FDD
| Crystal structure of HIV protease D545701 bound with GW0385 | 分子名称: | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL [(1S,2R)-3-[(1,3-BENZODIOXOL-5-YLSULFONYL)(ISOBUTYL)AMINO]-2-HYDROXY-1-{4-[(2-METHYL-1,3-THIAZOL-4-YL)METHOXY]BENZYL}PROPYL]CARBAMATE, Gag-Pol polyprotein | 著者 | Xu, R.X. | 登録日 | 2005-12-13 | 公開日 | 2006-02-21 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: The discovery of GW0385. Bioorg.Med.Chem.Lett., 16, 2006
|
|
2FDE
| Wild type HIV protease bound with GW0385 | 分子名称: | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL [(1S,2R)-3-[(1,3-BENZODIOXOL-5-YLSULFONYL)(ISOBUTYL)AMINO]-2-HYDROXY-1-{4-[(2-METHYL-1,3-THIAZOL-4-YL)METHOXY]BENZYL}PROPYL]CARBAMATE, Gag-Pol polyprotein, POTASSIUM ION | 著者 | Xu, R.X. | 登録日 | 2005-12-13 | 公開日 | 2006-02-21 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: The discovery of GW0385. Bioorg.Med.Chem.Lett., 16, 2006
|
|
4JPH
| Crystal structure of Protein Related to DAN and Cerberus (PRDC) | 分子名称: | CITRIC ACID, GLUTATHIONE, GLYCEROL, ... | 著者 | Deng, X, Nolan, K.T, Kattamuri, C, Thompson, T.B. | 登録日 | 2013-03-19 | 公開日 | 2013-07-24 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structure of protein related to dan and cerberus: insights into the mechanism of bone morphogenetic protein antagonism. Structure, 21, 2013
|
|
5TQP
| LIPOXYGENASE-1 (SOYBEAN) I553G MUTANT AT 300K | 分子名称: | FE (III) ION, Seed linoleate 13S-lipoxygenase-1 | 著者 | Poss, E.M, Fraser, J.S. | 登録日 | 2016-10-24 | 公開日 | 2017-11-01 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Hydrogen-Deuterium Exchange of Lipoxygenase Uncovers a Relationship between Distal, Solvent Exposed Protein Motions and the Thermal Activation Barrier for Catalytic Proton-Coupled Electron Tunneling. ACS Cent Sci, 3, 2017
|
|
7KHD
| Human GITR-GITRL complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 18, Tumor necrosis factor receptor superfamily member 18 | 著者 | Wang, F, Chau, B, West, S.M, Strop, P. | 登録日 | 2020-10-21 | 公開日 | 2021-03-03 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.956102 Å) | 主引用文献 | Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions. Nat Commun, 12, 2021
|
|
7KHX
| Mouse GITR-GITRL complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 18, ... | 著者 | Wang, F, Chau, B, West, S.M, Strop, P. | 登録日 | 2020-10-22 | 公開日 | 2021-03-03 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.20569849 Å) | 主引用文献 | Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions. Nat Commun, 12, 2021
|
|
4CPG
| |
5T5V
| LIPOXYGENASE-1 (SOYBEAN) AT 293K | 分子名称: | FE (III) ION, Seed linoleate 13S-lipoxygenase-1 | 著者 | Poss, E.M, Fraser, J.S. | 登録日 | 2016-08-31 | 公開日 | 2017-09-06 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Hydrogen-Deuterium Exchange of Lipoxygenase Uncovers a Relationship between Distal, Solvent Exposed Protein Motions and the Thermal Activation Barrier for Catalytic Proton-Coupled Electron Tunneling. ACS Cent Sci, 3, 2017
|
|
4DZ8
| human IgG1 Fc fragment Heterodimer | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region | 著者 | Strop, P. | 登録日 | 2012-02-29 | 公開日 | 2012-08-01 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Generating Bispecific Human IgG1 and IgG2 Antibodies from Any Antibody Pair. J.Mol.Biol., 420, 2012
|
|
7CBS
| Crystal structure of SpaB basal pilin from Lactobacillus rhamnosus GG | 分子名称: | CHLORIDE ION, LPXTG cell wall anchor domain-containing protein, MAGNESIUM ION | 著者 | Megta, A.K, Pratap, S, Kant, A, Krishnan, V. | 登録日 | 2020-06-13 | 公開日 | 2020-12-30 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Crystal structure of the atypically adhesive SpaB basal pilus subunit: Mechanistic insights about its incorporation in lactobacillar SpaCBA pili. Curr Res Struct Biol, 2, 2020
|
|
7UM3
| Crystal structure of a Fab in complex with a peptide derived from the LAG-3 D1 domain loop insertion | 分子名称: | D1 domain loop peptide from Lymphocyte activation gene 3 protein, Fab heavy chain, Fab light chain | 著者 | Zorn, J.A, Lee, P.S, Rajpal, A, Strop, P. | 登録日 | 2022-04-06 | 公開日 | 2022-09-07 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.3983 Å) | 主引用文献 | Preclinical Characterization of Relatlimab, a Human LAG-3-Blocking Antibody, Alone or in Combination with Nivolumab. Cancer Immunol Res, 10, 2022
|
|