7UM3
Crystal structure of a Fab in complex with a peptide derived from the LAG-3 D1 domain loop insertion
Summary for 7UM3
Entry DOI | 10.2210/pdb7um3/pdb |
Descriptor | Fab heavy chain, Fab light chain, D1 domain loop peptide from Lymphocyte activation gene 3 protein, ... (4 entities in total) |
Functional Keywords | antibody binding fragment, fab, lag-3, relatlimab, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 6 |
Total formula weight | 100193.14 |
Authors | Zorn, J.A.,Lee, P.S.,Rajpal, A.,Strop, P. (deposition date: 2022-04-06, release date: 2022-09-07, Last modification date: 2023-10-18) |
Primary citation | Thudium, K.,Selby, M.,Zorn, J.A.,Rak, G.,Wang, X.T.,Bunch, R.T.,Hogan, J.M.,Strop, P.,Korman, A.J. Preclinical Characterization of Relatlimab, a Human LAG-3-Blocking Antibody, Alone or in Combination with Nivolumab. Cancer Immunol Res, 10:1175-1189, 2022 Cited by PubMed: 35981087DOI: 10.1158/2326-6066.CIR-22-0057 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3983 Å) |
Structure validation
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