7UM3

Crystal structure of a Fab in complex with a peptide derived from the LAG-3 D1 domain loop insertion

Summary for 7UM3

• Entry DOI: 10.2210/pdb7um3/pdb
• Descriptor: Fab heavy chain, Fab light chain, D1 domain loop peptide from Lymphocyte activation gene 3 protein, ... (4 entities in total)
• Functional Keywords: antibody binding fragment, fab, lag-3, relatlimab, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 6
• Total formula weight: 100193.14

Authors

Zorn, J.A.,Lee, P.S.,Rajpal, A.,Strop, P. (deposition date: 2022-04-06, release date: 2022-09-07, Last modification date: 2023-10-18)

• Primary citation: Thudium, K.,Selby, M.,Zorn, J.A.,Rak, G.,Wang, X.T.,Bunch, R.T.,Hogan, J.M.,Strop, P.,Korman, A.J.; Preclinical Characterization of Relatlimab, a Human LAG-3-Blocking Antibody, Alone or in Combination with Nivolumab.; Cancer Immunol Res, 10:1175-1189, 2022; PubMed: 35981087; DOI: 10.1158/2326-6066.CIR-22-0057

Experimental method

X-RAY DIFFRACTION (2.3983 Å)