8HV3
 
 | | Crystal structure of EGFR_DMX in complex with covalently bound fragment 4 | | 分子名称: | 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, DIMETHYL SULFOXIDE, Epidermal growth factor receptor, ... | | 著者 | Dokurno, P. | | 登録日 | 2022-12-26 | | 公開日 | 2023-12-13 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | A covalent fragment-based strategy targeting a novel cysteine to inhibit activity of mutant EGFR kinase.
Rsc Med Chem, 14, 2023
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8HV9
 | | Crystal structure of EGFR_TMX in complex with covalently bound fragment 12 | | 分子名称: | 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, DIMETHYL SULFOXIDE, Epidermal growth factor receptor, ... | | 著者 | Dokurno, P. | | 登録日 | 2022-12-26 | | 公開日 | 2023-12-13 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | A covalent fragment-based strategy targeting a novel cysteine to inhibit activity of mutant EGFR kinase.
Rsc Med Chem, 14, 2023
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6KZX
 | | Crystal structure of E.coli DNA gyrase B in complex with 2-oxo-1,2-dihydroquinoline derivative | | 分子名称: | 3-[[8-(methylamino)-2-oxidanylidene-1~{H}-quinolin-3-yl]carbonylamino]benzoic acid, DNA gyrase subunit B | | 著者 | Mima, M, Takeuchi, T, Ushiyama, F. | | 登録日 | 2019-09-25 | | 公開日 | 2020-05-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Lead Identification of 8-(Methylamino)-2-oxo-1,2-dihydroquinoline Derivatives as DNA Gyrase Inhibitors: Hit-to-Lead Generation Involving Thermodynamic Evaluation.
Acs Omega, 5, 2020
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7WBT
 | | Crystal structure of bovine NLRP9 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, NACHT, LRR and PYD domains-containing protein 9 | | 著者 | Kamitsukasa, Y, Shimizu, T, Ohto, U. | | 登録日 | 2021-12-17 | | 公開日 | 2022-04-06 | | 最終更新日 | 2022-04-27 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | The structure of NLRP9 reveals a unique C-terminal region with putative regulatory function.
Febs Lett., 596, 2022
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7WBU
 | | Cryo-EM structure of bovine NLRP9 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, NACHT, LRR and PYD domains-containing protein 9 | | 著者 | Kamitsukasa, Y, Shimizu, T, Ohto, U. | | 登録日 | 2021-12-17 | | 公開日 | 2022-04-06 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (3.42 Å) | | 主引用文献 | The structure of NLRP9 reveals a unique C-terminal region with putative regulatory function.
Febs Lett., 596, 2022
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6L01
 | | Crystal structure of E.coli DNA gyrase B in complex with 2-oxo-1,2-dihydroquinoline derivative | | 分子名称: | 2-[3-[[8-(methylamino)-2-oxidanylidene-1~{H}-quinolin-3-yl]carbonylamino]phenyl]ethanoic acid, DNA gyrase subunit B | | 著者 | Mima, M, Takeuchi, T, Ushiyama, F. | | 登録日 | 2019-09-25 | | 公開日 | 2020-05-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Lead Identification of 8-(Methylamino)-2-oxo-1,2-dihydroquinoline Derivatives as DNA Gyrase Inhibitors: Hit-to-Lead Generation Involving Thermodynamic Evaluation.
Acs Omega, 5, 2020
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6KZV
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6KZZ
 | | Crystal structure of E.coli DNA gyrase B in complex with 2-oxo-1,2-dihydroquinoline derivative | | 分子名称: | 4-[[8-(methylamino)-2-oxidanylidene-1~{H}-quinolin-3-yl]carbonylamino]benzoic acid, DNA gyrase subunit B | | 著者 | Mima, M, Takeuchi, T, Ushiyama, F. | | 登録日 | 2019-09-25 | | 公開日 | 2020-05-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Lead Identification of 8-(Methylamino)-2-oxo-1,2-dihydroquinoline Derivatives as DNA Gyrase Inhibitors: Hit-to-Lead Generation Involving Thermodynamic Evaluation.
Acs Omega, 5, 2020
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1RT8
 | | CRYSTAL STRUCTURE OF THE ACTIN-CROSSLINKING CORE OF SCHIZOSACCHAROMYCES POMBE FIMBRIN | | 分子名称: | SULFATE ION, fimbrin | | 著者 | Klein, M.G, Shi, W, Ramagopal, U, Tseng, Y, Wirtz, D, Kovar, D.R, Staiger, C.J, Almo, S.C. | | 登録日 | 2003-12-10 | | 公開日 | 2004-06-22 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure of the actin crosslinking core of fimbrin.
Structure, 12, 2004
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2ZYE
 | | Structure of HIV-1 Protease in Complex with Potent Inhibitor KNI-272 Determined by Neutron Crystallography | | 分子名称: | (4R)-N-tert-butyl-3-[(2S,3S)-2-hydroxy-3-({N-[(isoquinolin-5-yloxy)acetyl]-S-methyl-L-cysteinyl}amino)-4-phenylbutanoyl]-1,3-thiazolidine-4-carboxamide, protease | | 著者 | Adachi, M, Ohhara, T, Tamada, T, Okazaki, N, Kuroki, R. | | 登録日 | 2009-01-20 | | 公開日 | 2009-03-24 | | 最終更新日 | 2024-05-29 | | 実験手法 | NEUTRON DIFFRACTION (1.9 Å) | | 主引用文献 | Structure of HIV-1 protease in complex with potent inhibitor KNI-272 determined by high-resolution X-ray and neutron crystallography.
Proc.Natl.Acad.Sci.USA, 2009
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3ABH
 | | Crystal structure of the EFC/F-BAR domain of human PACSIN2/Syndapin II (2.0 A) | | 分子名称: | Protein kinase C and casein kinase substrate in neurons protein 2 | | 著者 | Shimada, A, Shirouzu, M, Hanawa-Suetsugu, K, Terada, T, Umehara, T, Suetsugu, S, Yamamoto, M, Yokoyama, S. | | 登録日 | 2009-12-11 | | 公開日 | 2010-04-14 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Mapping of the basic amino-acid residues responsible for tubulation and cellular protrusion by the EFC/F-BAR domain of pacsin2/Syndapin II
Febs Lett., 584, 2010
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3ACO
 | | Crystal structure of the EFC/F-BAR domain of human PACSIN2/Syndapin II (2.7 A) | | 分子名称: | CALCIUM ION, Protein kinase C and casein kinase substrate in neurons protein 2 | | 著者 | Shimada, A, Shirouzu, M, Hanawa-Suetsugu, K, Terada, T, Umehara, T, Suetsugu, S, Yamamoto, M, Yokoyama, S. | | 登録日 | 2010-01-07 | | 公開日 | 2010-04-14 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Mapping of the basic amino-acid residues responsible for tubulation and cellular protrusion by the EFC/F-BAR domain of pacsin2/Syndapin II
Febs Lett., 584, 2010
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2DVR
 | | Crystal structure analysis of the N-terminal bromodomain of human BRD2 complexed with acetylated histone H4 peptide | | 分子名称: | bromodomain-containing protein 2, histone H4 | | 著者 | Nakamura, Y, Umehara, T, Shirouzu, M, Padmanabhan, B, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2006-08-01 | | 公開日 | 2007-08-07 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural Basis for Acetylated Histone H4 Recognition by the Human BRD2 Bromodomain.
J.Biol.Chem., 285, 2010
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2DVS
 | | Crystal structure analysis of the N-terminal bromodomain of human BRD2 complexed with acetylated histone H4 peptide | | 分子名称: | bromodomain-containing protein 2, histone H4 | | 著者 | Nakamura, Y, Umehara, T, Shirouzu, M, Padmanabhan, B, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2006-08-01 | | 公開日 | 2007-08-07 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | Structural Basis for Acetylated Histone H4 Recognition by the Human BRD2 Bromodomain.
J.Biol.Chem., 285, 2010
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2E3K
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2DVQ
 | | Crystal structure analysis of the N-terminal bromodomain of human BRD2 complexed with acetylated histone H4 peptide | | 分子名称: | Bromodomain-containing protein 2, histone H4 | | 著者 | Nakamura, Y, Umehara, T, Shirouzu, M, Padmanabhan, B, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2006-08-01 | | 公開日 | 2007-08-07 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | Structural Basis for Acetylated Histone H4 Recognition by the Human BRD2 Bromodomain.
J.Biol.Chem., 285, 2010
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3VN5
 | | Crystal structure of Aquifex aeolicus RNase H3 | | 分子名称: | Ribonuclease HIII | | 著者 | Jongruja, N, You, D.J, Eiko, K, Angkawidjaja, C, Koga, Y, Takano, K, Kanaya, S. | | 登録日 | 2011-12-22 | | 公開日 | 2012-12-26 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | Structure and characterization of RNase H3 from Aquifex aeolicus
Febs J., 279, 2012
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1VFL
 | | Adenosine deaminase | | 分子名称: | Adenosine deaminase, ZINC ION | | 著者 | Kinoshita, T. | | 登録日 | 2004-04-16 | | 公開日 | 2005-08-16 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural Basis of Compound Recognition by Adenosine Deaminase
Biochemistry, 44, 2005
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2ZJ7
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2ZJ6
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1WXY
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3AQO
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6K76
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6K79
 | | Glycerol kinase form Thermococcus kodakarensis, complex structure with substrate. | | 分子名称: | GLYCEROL, Glycerol kinase, TRIETHYLENE GLYCOL | | 著者 | Koga, Y, Angkawidjaja, C, Matsumura, H, Hokao, R. | | 登録日 | 2019-06-06 | | 公開日 | 2020-06-10 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | Structural analysis of hexameric structure of glycerol kinase from Thermococcus kodakaraeinsis KOD1
To Be Published
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6K78
 | | Glycerol kinase form Thermococcus kodakarensis, complex structure with substrate. | | 分子名称: | GLYCEROL, Glycerol kinase, TRIETHYLENE GLYCOL | | 著者 | Koga, Y, Angkawidjaja, C, Matsumura, H, Hokao, R. | | 登録日 | 2019-06-06 | | 公開日 | 2020-06-10 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.301 Å) | | 主引用文献 | Structural analysis of hexameric structure of glycerol kinase from Thermococcus kodakaraeinsis KOD1
To Be Published
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