2DVR

Crystal structure analysis of the N-terminal bromodomain of human BRD2 complexed with acetylated histone H4 peptide

Summary for 2DVR

• Entry DOI: 10.2210/pdb2dvr/pdb
• Related: 1X0J 2DVQ 2dvs
• Descriptor: bromodomain-containing protein 2, histone H4 (3 entities in total)
• Functional Keywords: alpha-helical domain, bromodomain, binds to acetylated histones, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi, transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus (By similarity): P25440
• Total number of polymer chains: 5
• Total formula weight: 47145.48

Authors

Nakamura, Y.,Umehara, T.,Shirouzu, M.,Padmanabhan, B.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2006-08-01, release date: 2007-08-07, Last modification date: 2024-04-03)

• Primary citation: Umehara, T.,Nakamura, Y.,Jang, M.K.,Nakano, K.,Tanaka, A.,Ozato, K.,Padmanabhan, B.,Yokoyama, S.; Structural Basis for Acetylated Histone H4 Recognition by the Human BRD2 Bromodomain.; J.Biol.Chem., 285:7610-7618, 2010; PubMed: 20048151; DOI: 10.1074/jbc.M109.062422

Experimental method

X-RAY DIFFRACTION (2.3 Å)