6L01

Crystal structure of E.coli DNA gyrase B in complex with 2-oxo-1,2-dihydroquinoline derivative

Summary for 6L01

Entry DOI	10.2210/pdb6l01/pdb
Related	6KZV 6KZX 6KZZ
Descriptor	DNA gyrase subunit B, 2-[3-[[8-(methylamino)-2-oxidanylidene-1~{H}-quinolin-3-yl]carbonylamino]phenyl]ethanoic acid (3 entities in total)
Functional Keywords	inhibitor, complex, topoisomerase, escherichia coli, isomerase
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	24542.54
Authors	Mima, M.,Takeuchi, T.,Ushiyama, F. (deposition date: 2019-09-25, release date: 2020-05-06, Last modification date: 2023-11-22)
Primary citation	Ushiyama, F.,Amada, H.,Takeuchi, T.,Tanaka-Yamamoto, N.,Kanazawa, H.,Nakano, K.,Mima, M.,Masuko, A.,Takata, I.,Hitaka, K.,Iwamoto, K.,Sugiyama, H.,Ohtake, N. Lead Identification of 8-(Methylamino)-2-oxo-1,2-dihydroquinoline Derivatives as DNA Gyrase Inhibitors: Hit-to-Lead Generation Involving Thermodynamic Evaluation. Acs Omega, 5:10145-10159, 2020 Cited by PubMed: 32391502 DOI: 10.1021/acsomega.0c00865 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation