2DVS
Crystal structure analysis of the N-terminal bromodomain of human BRD2 complexed with acetylated histone H4 peptide
Summary for 2DVS
Entry DOI | 10.2210/pdb2dvs/pdb |
Related | 1X0J 2DVQ 2DVR |
Descriptor | bromodomain-containing protein 2, histone H4 (3 entities in total) |
Functional Keywords | alpha-helical domain, bromodomain, binds to acetylated histones, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi, transcription |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus (By similarity): P25440 |
Total number of polymer chains | 5 |
Total formula weight | 47107.69 |
Authors | Nakamura, Y.,Umehara, T.,Shirouzu, M.,Padmanabhan, B.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2006-08-01, release date: 2007-08-07, Last modification date: 2011-07-13) |
Primary citation | Umehara, T.,Nakamura, Y.,Jang, M.K.,Nakano, K.,Tanaka, A.,Ozato, K.,Padmanabhan, B.,Yokoyama, S. Structural Basis for Acetylated Histone H4 Recognition by the Human BRD2 Bromodomain. J.Biol.Chem., 285:7610-7618, 2010 Cited by PubMed: 20048151DOI: 10.1074/jbc.M109.062422 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.04 Å) |
Structure validation
Download full validation report