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2DVS

Crystal structure analysis of the N-terminal bromodomain of human BRD2 complexed with acetylated histone H4 peptide

Summary for 2DVS
Entry DOI10.2210/pdb2dvs/pdb
Related1X0J 2DVQ 2DVR
Descriptorbromodomain-containing protein 2, histone H4 (3 entities in total)
Functional Keywordsalpha-helical domain, bromodomain, binds to acetylated histones, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi, transcription
Biological sourceHomo sapiens (human)
More
Cellular locationNucleus (By similarity): P25440
Total number of polymer chains5
Total formula weight47107.69
Authors
Nakamura, Y.,Umehara, T.,Shirouzu, M.,Padmanabhan, B.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2006-08-01, release date: 2007-08-07, Last modification date: 2011-07-13)
Primary citationUmehara, T.,Nakamura, Y.,Jang, M.K.,Nakano, K.,Tanaka, A.,Ozato, K.,Padmanabhan, B.,Yokoyama, S.
Structural Basis for Acetylated Histone H4 Recognition by the Human BRD2 Bromodomain.
J.Biol.Chem., 285:7610-7618, 2010
Cited by
PubMed: 20048151
DOI: 10.1074/jbc.M109.062422
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.04 Å)
Structure validation

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