5XAF
 
 | | Crystal structure of tubulin-stathmin-TTL-Compound Z1 complex | | 分子名称: | (3S,4R)-4-(3-hydroxy-4-methoxyphenyl)-3-methyl-1-(3,4,5-trimethoxyphenyl)azetidin-2-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | 著者 | Zhang, H, Luo, C, Wang, Y. | | 登録日 | 2017-03-12 | | 公開日 | 2017-12-20 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.551 Å) | | 主引用文献 | Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral beta-lactam bridged combretastatin A-4 analogues as potent antitumor agents
Eur J Med Chem, 144, 2017
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4KTC
 | | NS3/NS4A protease with inhibitor | | 分子名称: | (2R,6S,13aR,14aR,16aS)-6-{[(cyclopentyloxy)carbonyl]amino}-14a-[(cyclopropylsulfonyl)carbamoyl]-5,16-dioxooctadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 3,4-dihydroisoquinoline-2(1H)-carboxylate, NS4A peptide, Serine protease NS3, ... | | 著者 | Zhang, H, Ballard, J, Vigers, G.P.A, Brandhuber, B.J. | | 登録日 | 2013-05-20 | | 公開日 | 2013-08-07 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Discovery of Danoprevir (ITMN-191/R7227), a Highly Selective and Potent Inhibitor of Hepatitis C Virus (HCV) NS3/4A Protease.
J.Med.Chem., 57, 2014
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5XRS
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5XOM
 | | Hydra Fam20 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycosaminoglycan xylosylkinase | | 著者 | Xiao, J, Zhang, H. | | 登録日 | 2017-05-29 | | 公開日 | 2018-04-11 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure and evolution of the Fam20 kinases
Nat Commun, 9, 2018
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7WET
 | | Crystal structure of Peroxiredoxin I in complex with the inhibitor Cela | | 分子名称: | (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid, Peroxiredoxin-1 | | 著者 | Zhang, H, Luo, C. | | 登録日 | 2021-12-24 | | 公開日 | 2022-12-28 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1.
Signal Transduct Target Ther, 8, 2023
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7WEU
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5XRT
 | | Crystal structure of A/Minnesota/11/2010 (H3N2) influenza virus hemagglutinin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhang, H, Wilson, I.A. | | 登録日 | 2017-06-09 | | 公開日 | 2018-07-25 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | | 主引用文献 | A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA.
Nat Commun, 9, 2018
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5XRQ
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4TMF
 | | Crystal structure of human CD38 in complex with hydrolysed compound JMS713 | | 分子名称: | 5-O-[(R)-{[(S)-[4-(8-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)butoxy](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-alpha-D- ribofuranose, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | | 著者 | Zhang, H, Swarbrick, J, Potter, B, Hao, Q. | | 登録日 | 2014-06-01 | | 公開日 | 2015-05-13 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Cyclic adenosine 5'-diphosphate ribose analogs without a "southern" ribose inhibit ADP-ribosyl cyclase-hydrolase CD38.
J.Med.Chem., 57, 2014
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2K0N
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7BWO
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7BWE
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7XND
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5O2W
 | | Extended catalytic domain of Hypocrea jecorina LPMO 9A. | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, COPPER (II) ION, Glycoside hydrolase family 61, ... | | 著者 | Karkehabadi, S, Hansson, H, Sandgren, M, Mikelssen, N.E. | | 登録日 | 2017-05-23 | | 公開日 | 2017-09-20 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | High-resolution structure of a lytic polysaccharide monooxygenase from Hypocrea jecorina reveals a predicted linker as an integral part of the catalytic domain.
J. Biol. Chem., 292, 2017
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7JR7
 | | Cryo-EM structure of ABCG5/G8 in complex with Fab 2E10 and 11F4 | | 分子名称: | ATP-binding cassette sub-family G member 5, ATP-binding cassette sub-family G member 8, Fab 11F4 heavy chain, ... | | 著者 | Huang, C.S, Yu, X, Min, X, Wang, Z, Zhang, H. | | 登録日 | 2020-08-11 | | 公開日 | 2021-04-07 | | 最終更新日 | 2021-05-12 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Cryo-EM structure of ABCG5/G8 in complex with modulating antibodies
Commun Biol, 4, 2021
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4KV4
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4KV1
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2VAN
 | | Nucleotidyl Transfer Mechanism of Mismatched dNTP Incorporation by DNA Polymerase b by Structural and Kinetic Analyses | | 分子名称: | DNA POLYMERSE BETA | | 著者 | Chan, H, Chou, C, Tang, K, Niebuhr, M, Tung, C, Tsai, M. | | 登録日 | 2007-09-03 | | 公開日 | 2008-04-15 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Mismatched Dntp Incorporation by DNA Polymerase Beta Does not Proceed Via Globally Different Conformational Pathways.
Nucleic Acids Res., 36, 2008
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7W0S
 | | TRIM7 in complex with C-terminal peptide of 2C | | 分子名称: | DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase TRIM7, GLYCEROL, ... | | 著者 | Zhang, H, Liang, X, Li, X.Z. | | 登録日 | 2021-11-18 | | 公開日 | 2022-08-10 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | A C-terminal glutamine recognition mechanism revealed by E3 ligase TRIM7 structures.
Nat.Chem.Biol., 18, 2022
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7W0Q
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7W0T
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7X32
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7X6Z
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7X70
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7X6Y
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