7WEU

Crystal structure of Peroxiredoxin I in complex with compound 19-048

Summary for 7WEU

• Entry DOI: 10.2210/pdb7weu/pdb
• Descriptor: Peroxiredoxin-1, UNKNOWN LIGAND (3 entities in total)
• Functional Keywords: inhibitor, complex, peroxiredoxin, oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 38777.25

Authors

Zhang, H.,Luo, C. (deposition date: 2021-12-24, release date: 2022-12-28, Last modification date: 2023-11-29)

• Primary citation: Xu, H.,Zhao, H.,Ding, C.,Jiang, D.,Zhao, Z.,Li, Y.,Ding, X.,Gao, J.,Zhou, H.,Luo, C.,Chen, G.,Zhang, A.,Xu, Y.,Zhang, H.; Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1.; Signal Transduct Target Ther, 8:51-51, 2023; PubMed: 36732502; DOI: 10.1038/s41392-022-01231-4

Experimental method

X-RAY DIFFRACTION (1.81 Å)