8XW3
 
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8XS5
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8XW0
 | | Cryo-EM structure of OSCA3.1-GDN state | | 分子名称: | CSC1-like protein ERD4, O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine | | 著者 | Zhang, Y, Han, Y. | | 登録日 | 2024-01-15 | | 公開日 | 2024-04-10 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | | 主引用文献 | Mechanical activation opens a lipid-lined pore in OSCA ion channels.
Nature, 628, 2024
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8XVY
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8XVZ
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8XW4
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8XAJ
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8XS0
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8XVX
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8XRY
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5D4D
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5D4C
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5D4E
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4JND
 | | Structure of a C.elegans sex determining protein | | 分子名称: | Ca(2+)/calmodulin-dependent protein kinase phosphatase, MAGNESIUM ION | | 著者 | Feng, Y, Zhang, Y, Ge, J, Yang, M. | | 登録日 | 2013-03-15 | | 公開日 | 2013-06-19 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.652 Å) | | 主引用文献 | Structural insight into Caenorhabditis elegans sex-determining protein FEM-2.
J.Biol.Chem., 288, 2013
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7D6F
 | | The crystal structure of ARMS-PBM/MAGI2-PDZ4 | | 分子名称: | GLYCEROL, Kinase D-interacting substrate of 220 kDa, Membrane-associated guanylate kinase, ... | | 著者 | Ye, J, Zhang, Y, Zhong, Z, Wang, C. | | 登録日 | 2020-09-30 | | 公開日 | 2020-11-04 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.001 Å) | | 主引用文献 | Crystal structure of the PDZ4 domain of MAGI2 in complex with PBM of ARMS reveals a canonical PDZ recognition mode.
Neurochem.Int., 149, 2021
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4K7F
 | | Newly identified epitope V60 from HBV core protein complexed with HLA-A*0201 | | 分子名称: | Beta-2-microglobulin, Core protein, HLA class I histocompatibility antigen, ... | | 著者 | Meng, S.D, Zhang, Y, Wu, Y, Qi, J.X. | | 登録日 | 2013-04-17 | | 公開日 | 2013-06-05 | | 最終更新日 | 2022-08-24 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The L60V variation in hepatitis B virus core protein elicits new epitope-specific cytotoxic T lymphocytes and enhances viral replication.
J.Virol., 87, 2013
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2I0L
 | | X-ray crystal structure of Sap97 PDZ2 bound to the C-terminal peptide of HPV18 E6. | | 分子名称: | Disks large homolog 1, peptide E6 | | 著者 | Chen, X.S, Zhang, Y, Dasgupta, J, Banks, L, Thomas, M. | | 登録日 | 2006-08-10 | | 公開日 | 2007-02-20 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | | 主引用文献 | Structures of a Human Papillomavirus (HPV) E6 Polypeptide Bound to MAGUK Proteins: Mechanisms of Targeting Tumor Suppressors by a High-Risk HPV Oncoprotein.
J.Virol., 81, 2007
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2I04
 | | X-ray crystal structure of MAGI-1 PDZ1 bound to the C-terminal peptide of HPV18 E6 | | 分子名称: | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1, SULFATE ION, ... | | 著者 | Chen, X.S, Zhang, Y, Dasgupta, J, Banks, L, Thomas, M. | | 登録日 | 2006-08-09 | | 公開日 | 2007-02-20 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Structures of a Human Papillomavirus (HPV) E6 Polypeptide Bound to MAGUK Proteins: Mechanisms of Targeting Tumor Suppressors by a High-Risk HPV Oncoprotein.
J.Virol., 81, 2007
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2ITK
 | | human Pin1 bound to D-PEPTIDE | | 分子名称: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, D-Peptide, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | | 著者 | Noel, J.P, Zhang, Y. | | 登録日 | 2006-10-19 | | 公開日 | 2007-05-22 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Structural basis for high-affinity peptide inhibition of human Pin1.
Acs Chem.Biol., 2, 2007
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2I0I
 | | X-ray crystal structure of Sap97 PDZ3 bound to the C-terminal peptide of HPV18 E6 | | 分子名称: | Disks large homolog 1, peptide E6 | | 著者 | Chen, X.S, Zhang, Y, Dasgupta, J, Banks, L, Thomas, M. | | 登録日 | 2006-08-10 | | 公開日 | 2007-02-20 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structures of a Human Papillomavirus (HPV) E6 Polypeptide Bound to MAGUK Proteins: Mechanisms of Targeting Tumor Suppressors by a High-Risk HPV Oncoprotein.
J.Virol., 81, 2007
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5LS6
 | | Structure of Human Polycomb Repressive Complex 2 (PRC2) with inhibitor | | 分子名称: | 1-[(1~{R})-1-[1-[2,2-bis(fluoranyl)propyl]piperidin-4-yl]ethyl]-~{N}-[(4-methoxy-6-methyl-2-oxidanylidene-3~{H}-pyridin-3-yl)methyl]-2-methyl-indole-3-carboxamide, Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2, Jarid2 K116me3, ... | | 著者 | Zhang, Y, Justin, N, Chen, S, Wilson, J, Gamblin, S. | | 登録日 | 2016-08-22 | | 公開日 | 2017-02-22 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.47 Å) | | 主引用文献 | Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas.
J. Med. Chem., 59, 2016
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5HYN
 | | Structure of Human Polycomb Repressive Complex 2 (PRC2) with oncogenic histone H3K27M peptide | | 分子名称: | H3K27M, Histone-lysine N-methyltransferase EZH2, JARID2 K116me3, ... | | 著者 | Zhang, Y, Justin, N, Wilson, J.R, Gamblin, S.J. | | 登録日 | 2016-02-01 | | 公開日 | 2016-05-11 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2.
Nat Commun, 7, 2016
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3V7T
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8H7G
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3NTP
 | | Human Pin1 complexed with reduced amide inhibitor | | 分子名称: | (2R)-2-(acetylamino)-3-[(2S)-2-{[2-(1H-indol-3-yl)ethyl]carbamoyl}pyrrolidin-1-yl]propyl dihydrogen phosphate, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | | 著者 | Zhang, Y. | | 登録日 | 2010-07-05 | | 公開日 | 2012-01-04 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.762 Å) | | 主引用文献 | A reduced-amide inhibitor of Pin1 binds in a conformation resembling a twisted-amide transition state.
Biochemistry, 50, 2011
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