3V7T
Crystal Structure of Human Beta-Tryptase Complexed with a Synthetic Inhibitor with a Tropanylamide Scaffold
Summary for 3V7T
Entry DOI | 10.2210/pdb3v7t/pdb |
Descriptor | TPSB2 protein, {(3-exo)-3-[5-(aminomethyl)-2-fluorophenyl]-8-azabicyclo[3.2.1]oct-8-yl}(4-bromo-3-methyl-5-propoxythiophen-2-yl)methanone, CARBONATE ION, ... (4 entities in total) |
Functional Keywords | tryptase, serine protease, tetramer, protein-ligand complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 112067.51 |
Authors | Zhang, Y.,Colonna, C.,Michot, N. (deposition date: 2011-12-22, release date: 2012-03-14, Last modification date: 2017-11-08) |
Primary citation | Liang, G.,Choi-Sledeski, Y.M.,Shum, P.,Chen, X.,Poli, G.B.,Kumar, V.,Minnich, A.,Wang, Q.,Tsay, J.,Sides, K.,Kang, J.,Zhang, Y. A beta-tryptase inhibitor with a tropanylamide scaffold to improve in vitro stability and to lower hERG channel binding affinity Bioorg.Med.Chem.Lett., 22:1606-1610, 2012 Cited by PubMed: 22264487DOI: 10.1016/j.bmcl.2011.12.127 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.09 Å) |
Structure validation
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