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8G3C
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BU of 8g3c by Molmil
Crystal structure of human WDR5 in complex with N-[(2'-cyano[1,1'-biphenyl]-4-yl)methyl]-3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxamide (compound 1, WDR5-MYC PPI inhibitor)
分子名称: N-[(2'-cyano[1,1'-biphenyl]-4-yl)methyl]-3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxamide, WD repeat-containing protein 5
著者Zhao, M.
登録日2023-02-07
公開日2023-06-28
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Discovery and Structure-Based Design of Inhibitors of the WD Repeat-Containing Protein 5 (WDR5)-MYC Interaction.
J.Med.Chem., 66, 2023
8G3E
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BU of 8g3e by Molmil
Crystal structure of human WDR5 in complex with (1M)-N-[(3,5-difluoro[1,1'-biphenyl]-4-yl)methyl]-6-methyl-4-oxo-1-(pyridin-3-yl)-1,4-dihydropyridazine-3-carboxamide (compound 2, WDR5-MYC inhibitor)
分子名称: (1M)-N-[(3,5-difluoro[1,1'-biphenyl]-4-yl)methyl]-6-methyl-4-oxo-1-(pyridin-3-yl)-1,4-dihydropyridazine-3-carboxamide, WD repeat-containing protein 5
著者Zhao, M.
登録日2023-02-07
公開日2023-06-28
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.33 Å)
主引用文献Discovery and Structure-Based Design of Inhibitors of the WD Repeat-Containing Protein 5 (WDR5)-MYC Interaction.
J.Med.Chem., 66, 2023
8GVJ
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BU of 8gvj by Molmil
Crystal structure of cMET kinase domain bound by D6808
分子名称: (1^4Z,5^2E)-6^3-(trifluoromethyl)-5^1,5^6-dihydro-1^1H-8-aza-2(3,6)-quinolina-5(1,3)-pyridazina-1(4,1)-pyrazola-6(1,4)-benzenacyclododecaphane-5^6,7-dione, Hepatocyte growth factor receptor
著者Chen, Y.H, Qu, L.Z.
登録日2022-09-15
公開日2022-11-23
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献Discovery of D6808, a Highly Selective and Potent Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring MET Gene Alteration Treatment.
J.Med.Chem., 65, 2022
8H89
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BU of 8h89 by Molmil
Capsid of Ralstonia phage GP4
分子名称: Major capsid protein, Virion associated protein
著者Liu, H.R, Chen, W.Y.
登録日2022-10-22
公開日2022-11-16
最終更新日2023-08-30
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献A Capsid Structure of Ralstonia solanacearum podoviridae GP4 with a Triangulation Number T = 9.
Viruses, 14, 2022
8H3Z
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BU of 8h3z by Molmil
Crystal structure of the effector-binding domain of the LysR-type trasncription factor NtcB from Anabaena PCC 7120
分子名称: IODIDE ION, NtcB
著者Han, S.J, Jiang, Y.L, Zhou, C.Z.
登録日2022-10-09
公開日2023-10-04
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献DNA looping mediates cooperative transcription activation.
Nat.Struct.Mol.Biol., 31, 2024
7EQ1
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BU of 7eq1 by Molmil
GPR114-Gs-scFv16 complex
分子名称: Adhesion G-protein coupled receptor G5, Gs protein alpha subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Ping, Y.
登録日2021-04-28
公開日2022-05-11
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structural basis for the tethered peptide activation of adhesion GPCRs.
Nature, 604, 2022
4LX4
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BU of 4lx4 by Molmil
Crystal Structure Determination of Pseudomonas stutzeri endoglucanase Cel5A using a Twinned Data Set
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Endoglucanase(Endo-1,4-beta-glucanase)protein
著者Dutoit, R, Delsaute, M, Berlemont, R, Van Elder, D, Galleni, M, Bauvois, C.
登録日2013-07-29
公開日2014-07-30
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.556 Å)
主引用文献Crystal structure determination of Pseudomonas stutzeri A1501 endoglucanase Cel5A: the search for a molecular basis for glycosynthesis in GH5_5 enzymes.
Acta Crystallogr D Struct Biol, 75, 2019
7XEV
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BU of 7xev by Molmil
Structure of mTRPV2_2-APB
分子名称: 2-aminoethyl diphenylborinate, Transient receptor potential cation channel subfamily V member 2
著者Su, N.
登録日2022-03-31
公開日2022-08-17
最終更新日2023-03-01
実験手法ELECTRON MICROSCOPY (3.27 Å)
主引用文献Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands.
Nat.Chem.Biol., 19, 2023
7XEU
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Structure of mTRPV2_E2
分子名称: CHOLESTEROL, Transient receptor potential cation channel subfamily V member 2
著者Su, N.
登録日2022-03-31
公開日2022-08-17
最終更新日2023-03-01
実験手法ELECTRON MICROSCOPY (2.77 Å)
主引用文献Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands.
Nat.Chem.Biol., 19, 2023
7XEO
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BU of 7xeo by Molmil
MbetaCD treated state of mTRPV2
分子名称: Transient receptor potential cation channel subfamily V member 2
著者Su, N.
登録日2022-03-31
公開日2022-08-17
最終更新日2023-03-01
実験手法ELECTRON MICROSCOPY (2.89 Å)
主引用文献Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands.
Nat.Chem.Biol., 19, 2023
7XEW
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BU of 7xew by Molmil
Structure of mTRPV2_Q525F
分子名称: Transient receptor potential cation channel subfamily V member 2
著者Su, N.
登録日2022-03-31
公開日2022-08-17
最終更新日2023-03-01
実験手法ELECTRON MICROSCOPY (2.59 Å)
主引用文献Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands.
Nat.Chem.Biol., 19, 2023
7XER
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BU of 7xer by Molmil
Structure of mTRPV2_Q525T
分子名称: CHOLESTEROL, Transient receptor potential cation channel subfamily V member 2
著者Su, N.
登録日2022-03-31
公開日2022-08-17
最終更新日2023-03-01
実験手法ELECTRON MICROSCOPY (2.47 Å)
主引用文献Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands.
Nat.Chem.Biol., 19, 2023
7XEM
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BU of 7xem by Molmil
Cholesterol bound state of mTRPV2
分子名称: CHOLESTEROL, Transient receptor potential cation channel subfamily V member 2
著者Su, N.
登録日2022-03-31
公開日2022-08-17
最終更新日2023-03-01
実験手法ELECTRON MICROSCOPY (3.17 Å)
主引用文献Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands.
Nat.Chem.Biol., 19, 2023
7YEP
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BU of 7yep by Molmil
2-APB bound state of mTRPV2
分子名称: 2-aminoethyl diphenylborinate, Transient receptor potential cation channel subfamily V member 2
著者Su, N.
登録日2022-07-06
公開日2022-08-17
最終更新日2023-03-01
実験手法ELECTRON MICROSCOPY (2.83 Å)
主引用文献Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands.
Nat.Chem.Biol., 19, 2023
7W1S
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BU of 7w1s by Molmil
Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with neutralizing nanobody Nb-007
分子名称: Nanobody Nb-007, Spike protein S1
著者Yang, J, Lin, S, Sun, H.L, Lu, G.W.
登録日2021-11-20
公開日2022-06-29
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.997 Å)
主引用文献A Potent Neutralizing Nanobody Targeting the Spike Receptor-Binding Domain of SARS-CoV-2 and the Structural Basis of Its Intimate Binding.
Front Immunol, 13, 2022
7WKW
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BU of 7wkw by Molmil
NPA bound state of AtPIN3
分子名称: 2-(naphthalen-1-ylcarbamoyl)benzoic acid, Auxin efflux carrier component 3
著者Su, N.
登録日2022-01-11
公開日2022-08-10
最終更新日2022-09-28
実験手法ELECTRON MICROSCOPY (2.62 Å)
主引用文献Structures and mechanisms of the Arabidopsis auxin transporter PIN3.
Nature, 609, 2022
7WKS
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BU of 7wks by Molmil
Apo state of AtPIN3
分子名称: Auxin efflux carrier component 3
著者Su, N.
登録日2022-01-11
公開日2022-08-10
最終更新日2022-09-28
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structures and mechanisms of the Arabidopsis auxin transporter PIN3.
Nature, 609, 2022
7WN8
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BU of 7wn8 by Molmil
Crystal structure of antibody (BC31M5) binds to CD47
分子名称: BC31M5 Fab Heavy chain, BC31M5 Fab Light chain, Leukocyte surface antigen CD47, ...
著者Li, Y, Wang, W, Sui, J, Zhang, S.
登録日2022-01-17
公開日2023-01-25
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献A pH-dependent anti-CD47 antibody that selectively targets solid tumors and improves therapeutic efficacy and safety.
J Hematol Oncol, 16, 2023
7Y9N
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BU of 7y9n by Molmil
an engineered 5-helix bundle derived from SARS-CoV-2 S2 in complex with HR2P
分子名称: SARS-coV-2 S2 subunit, Spike protein S2',5HB-H2
著者Lu, G.W, Lin, X, Guo, L.Y, Lin, S.
登録日2022-06-25
公開日2022-08-17
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.885 Å)
主引用文献An engineered 5-helix bundle derived from SARS-CoV-2 S2 pre-binds sarbecoviral spike at both serological- and endosomal-pH to inhibit virus entry.
Emerg Microbes Infect, 11, 2022
7XXB
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BU of 7xxb by Molmil
IAA bound state of AtPIN3
分子名称: 1H-INDOL-3-YLACETIC ACID, Auxin efflux carrier component 3
著者Su, N.
登録日2022-05-29
公開日2022-08-10
最終更新日2022-09-28
実験手法ELECTRON MICROSCOPY (2.93 Å)
主引用文献Structures and mechanisms of the Arabidopsis auxin transporter PIN3.
Nature, 609, 2022
7E44
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BU of 7e44 by Molmil
Crystal structure of NudC complexed with dpCoA
分子名称: DEPHOSPHO COENZYME A, NADH pyrophosphatase, ZINC ION
著者Zhou, W, Guan, Z.Y, Yin, P, Zhang, D.L.
登録日2021-02-10
公開日2021-07-28
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural insights into dpCoA-RNA decapping by NudC.
Rna Biol., 18, 2021
6JL7
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BU of 6jl7 by Molmil
crystal structure of TBC1D23 N terminal domain
分子名称: TBC1 domain family member 23
著者Sun, Q, Hu, W, Jia, D.
登録日2019-03-04
公開日2020-03-04
最終更新日2021-09-15
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of TBC1D23 N-terminus reveals a novel role for rhodanese domain.
Plos Biol., 18, 2020
6KTR
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BU of 6ktr by Molmil
Crystal structure of fibroblast growth factor 19 in complex with Fab
分子名称: Fibroblast growth factor 19, G1A8-Fab-HC, G1A8-Fab-LC, ...
著者Liu, H, Zheng, S, Hou, X, Liu, X, Lv, X, Li, Y, Li, W, Sui, J.
登録日2019-08-28
公開日2020-07-08
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.59775758 Å)
主引用文献Novel Abs targeting the N-terminus of fibroblast growth factor 19 inhibit hepatocellular carcinoma growth without bile-acid-related side-effects.
Cancer Sci., 111, 2020
8JOU
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BU of 8jou by Molmil
Fiber I and fiber-tail-adaptor of phage GP4
分子名称: Virion-associated phage protein, rope protein of phage GP4
著者Liu, H, Chen, W.
登録日2023-06-08
公開日2024-01-03
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Asymmetric Structure of Podophage GP4 Reveals a Novel Architecture of Three Types of Tail Fibers.
J.Mol.Biol., 435, 2023
8JOV
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BU of 8jov by Molmil
Portal-tail complex of phage GP4
分子名称: Portal protein, Putative tail fiber protein, Virion associated protein, ...
著者Liu, H, Chen, W.
登録日2023-06-08
公開日2023-11-01
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Asymmetric Structure of Podophage GP4 Reveals a Novel Architecture of Three Types of Tail Fibers.
J.Mol.Biol., 435, 2023

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