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2JTQ
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Rhodanese from E.coli
分子名称: Phage shock protein E
著者Jin, C, Li, H.
登録日2007-08-06
公開日2008-06-17
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structures and backbone dynamics of Escherichia coli rhodanese PspE in its sulfur-free and persulfide-intermediate forms: implications for the catalytic mechanism of rhodanese.
Biochemistry, 47, 2008
8H5U
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BU of 8h5u by Molmil
Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with neutralizing nanobody Nb-021
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody Nb-021, ...
著者Yang, J, Lin, S, Lu, G.W.
登録日2022-10-13
公開日2023-10-18
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.401 Å)
主引用文献Development of a bispecific nanobody conjugate broadly neutralizes diverse SARS-CoV-2 variants and structural basis for its broad neutralization.
Plos Pathog., 19, 2023
2JSO
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BU of 2jso by Molmil
Antimicrobial resistance protein
分子名称: Polymyxin resistance protein pmrD
著者Jin, C, Fu, W.
登録日2007-07-10
公開日2007-09-04
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献First structure of the polymyxin resistance proteins.
Biochem.Biophys.Res.Commun., 361, 2007
2JTS
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BU of 2jts by Molmil
rhodanese with anions from E. coli
分子名称: Phage shock protein E
著者Jin, C, Li, H.
登録日2007-08-06
公開日2008-06-17
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structures and backbone dynamics of Escherichia coli rhodanese PspE in its sulfur-free and persulfide-intermediate forms: implications for the catalytic mechanism of rhodanese.
Biochemistry, 47, 2008
2K0N
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BU of 2k0n by Molmil
Solution Structure of Yeast Gal11p kix domain
分子名称: Mediator of RNA polymerase II transcription subunit 15
著者Arthanari, H, Frueh, D.P, Wagner, G.K, Naar, A.M.
登録日2008-02-04
公開日2008-03-25
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献A nuclear receptor-like pathway regulating multidrug resistance in fungi.
Nature, 452, 2008
2JSY
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BU of 2jsy by Molmil
Solution structure of Tpx in the oxidized state
分子名称: Probable thiol peroxidase
著者Jin, C, Lu, J.
登録日2007-07-17
公開日2008-07-22
最終更新日2022-03-16
実験手法SOLUTION NMR
主引用文献Reversible conformational switch revealed by the redox structures of Bacillus subtilis thiol peroxidase
Biochem.Biophys.Res.Commun., 373, 2008
2KM4
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BU of 2km4 by Molmil
Solution structure of Rtt103 CTD interacting domain
分子名称: Regulator of Ty1 transposition protein 103
著者Lunde, B.M, Reichow, S, Kim, M, Leeper, T.C, Becker, R, Buratowski, S, Meinhart, A, Varani, G.
登録日2009-07-20
公開日2010-09-08
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Cooperative interaction of transcription termination factors with the RNA polymerase II C-terminal domain.
Nat.Struct.Mol.Biol., 17, 2010
8II0
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BU of 8ii0 by Molmil
FACTOR INHIBITING HIF-1 ALPHA in complex with (5-(3-(3-chlorophenyl)isoxazol-5-yl)-3-hydroxypicolinoyl)glycine
分子名称: 2-[[5-[3-(3-chlorophenyl)-1,2-oxazol-5-yl]-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid, GLYCEROL, Hypoxia-inducible factor 1-alpha inhibitor, ...
著者Nakashima, Y, Corner, T, Zhang, X, Schofield, C.J.
登録日2023-02-24
公開日2024-02-28
最終更新日2024-07-10
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-flip Pocket for the Treatment of Obesity.
Angew.Chem.Int.Ed.Engl., 2024
8IHZ
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BU of 8ihz by Molmil
FACTOR INHIBITING HIF-1 ALPHA in complex with (5-(1-(3-(4-chlorophenyl)propyl)-1H-1,2,3-triazol-4-yl)-3-hydroxypicolinoyl)glycine
分子名称: 2-[[5-[1-[3-(4-chlorophenyl)propyl]-1,2,3-triazol-4-yl]-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid, Hypoxia-inducible factor 1-alpha inhibitor, SULFATE ION, ...
著者Nakashima, Y, Corner, T, Zhang, X, Schofield, C.J.
登録日2023-02-24
公開日2024-02-28
最終更新日2024-07-10
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-flip Pocket for the Treatment of Obesity.
Angew.Chem.Int.Ed.Engl., 2024
8GYB
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BU of 8gyb by Molmil
Crystal structure of Alongshan virus methyltransferase bound to S-adenosyl-L-homocysteine
分子名称: Methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者Chen, H, Lin, S, Lu, G.W.
登録日2022-09-22
公開日2023-09-27
最終更新日2024-04-10
実験手法X-RAY DIFFRACTION (2.101 Å)
主引用文献Structural and functional basis of low-affinity SAM/SAH-binding in the conserved MTase of the multi-segmented Alongshan virus distantly related to canonical unsegmented flaviviruses.
Plos Pathog., 19, 2023
8GYA
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BU of 8gya by Molmil
Crystal structure of Alongshan virus methyltransferase bound to Sinefungin
分子名称: Methyltransferase, SINEFUNGIN
著者Chen, H, Lin, S, Lu, G.W.
登録日2022-09-21
公開日2023-09-27
最終更新日2024-04-10
実験手法X-RAY DIFFRACTION (2.005 Å)
主引用文献Structural and functional basis of low-affinity SAM/SAH-binding in the conserved MTase of the multi-segmented Alongshan virus distantly related to canonical unsegmented flaviviruses.
Plos Pathog., 19, 2023
8GY4
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BU of 8gy4 by Molmil
Crystal structure of Alongshan virus methyltransferase
分子名称: Methyltransferase
著者Chen, H, Lin, S, Lu, G.W.
登録日2022-09-21
公開日2023-09-27
最終更新日2024-04-10
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural and functional basis of low-affinity SAM/SAH-binding in the conserved MTase of the multi-segmented Alongshan virus distantly related to canonical unsegmented flaviviruses.
Plos Pathog., 19, 2023
8GY9
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BU of 8gy9 by Molmil
Crystal structure of Alongshan virus methyltransferase bound to S-adenosyl-L-methionine
分子名称: Methyltransferase, S-ADENOSYLMETHIONINE
著者Chen, H, Lin, S, Lu, G.W.
登録日2022-09-21
公開日2023-09-27
最終更新日2024-04-10
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural and functional basis of low-affinity SAM/SAH-binding in the conserved MTase of the multi-segmented Alongshan virus distantly related to canonical unsegmented flaviviruses.
Plos Pathog., 19, 2023
8JLP
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BU of 8jlp by Molmil
Ralmitaront(RO-6889450)-bound hTAAR1-Gs protein complex
分子名称: 5-ethyl-4-methyl-~{N}-[4-[(2~{S})-morpholin-2-yl]phenyl]-1~{H}-pyrazole-3-carboxamide, Gs, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H.
登録日2023-06-02
公開日2023-11-15
最終更新日2024-01-03
実験手法ELECTRON MICROSCOPY (3.23 Å)
主引用文献Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
8JLK
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BU of 8jlk by Molmil
Ulotaront(SEP-363856)-bound mTAAR1-Gs protein complex
分子名称: 1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H.
登録日2023-06-02
公開日2023-11-15
最終更新日2024-01-03
実験手法ELECTRON MICROSCOPY (3.22 Å)
主引用文献Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
8JLQ
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BU of 8jlq by Molmil
Fenoldopam-bound hTAAR1-Gs protein complex
分子名称: (1R)-6-chloranyl-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H.
登録日2023-06-02
公開日2023-11-15
最終更新日2024-01-03
実験手法ELECTRON MICROSCOPY (2.84 Å)
主引用文献Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
8JLN
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T1AM-bound hTAAR1-Gs protein complex
分子名称: 4-[4-(2-azanylethyl)-2-iodanyl-phenoxy]phenol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H.
登録日2023-06-02
公開日2023-11-15
最終更新日2024-01-03
実験手法ELECTRON MICROSCOPY (3.24 Å)
主引用文献Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
8JLJ
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BU of 8jlj by Molmil
T1AM-bound mTAAR1-Gs protein complex
分子名称: 4-[4-(2-azanylethyl)-2-iodanyl-phenoxy]phenol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H.
登録日2023-06-02
公開日2023-11-15
最終更新日2024-01-03
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
8JLO
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BU of 8jlo by Molmil
Ulotaront(SEP-363856)-bound hTAAR1-Gs protein complex
分子名称: 1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H.
登録日2023-06-02
公開日2023-11-15
最終更新日2024-01-03
実験手法ELECTRON MICROSCOPY (3.52 Å)
主引用文献Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
8JLR
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A77636-bound hTAAR1-Gs protein complex
分子名称: (1~{S},3~{R})-3-(1-adamantyl)-1-(aminomethyl)-3,4-dihydro-1~{H}-isochromene-5,6-diol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H.
登録日2023-06-02
公開日2023-11-15
最終更新日2024-01-03
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
8JSO
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AMPH-bound hTAAR1-Gs protein complex
分子名称: (2S)-1-phenylpropan-2-amine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H.
登録日2023-06-20
公開日2023-11-15
最終更新日2024-01-03
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
8JSP
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BU of 8jsp by Molmil
Ulotaront(SEP-363856)-bound Serotonin 1A (5-HT1A) receptor-Gi complex
分子名称: 1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine, 5-hydroxytryptamine receptor 1A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H.
登録日2023-06-20
公開日2023-11-15
最終更新日2024-01-03
実験手法ELECTRON MICROSCOPY (3.65 Å)
主引用文献Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
7JVN
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Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Compound 24
分子名称: 6-(4-amino-4-methylpiperidin-1-yl)-3-[(2,3-dichlorophenyl)sulfanyl]pyrazin-2-amine, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 11
著者Fodor, M, Stams, T.
登録日2020-08-21
公開日2020-09-23
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.917 Å)
主引用文献Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer.
J.Med.Chem., 63, 2020
7W1S
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BU of 7w1s by Molmil
Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with neutralizing nanobody Nb-007
分子名称: Nanobody Nb-007, Spike protein S1
著者Yang, J, Lin, S, Sun, H.L, Lu, G.W.
登録日2021-11-20
公開日2022-06-29
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.997 Å)
主引用文献A Potent Neutralizing Nanobody Targeting the Spike Receptor-Binding Domain of SARS-CoV-2 and the Structural Basis of Its Intimate Binding.
Front Immunol, 13, 2022
7JVM
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Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor TNO155
分子名称: (3S,4S)-8-{6-amino-5-[(2-amino-3-chloropyridin-4-yl)sulfanyl]pyrazin-2-yl}-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-amine, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 11
著者Fodor, M, Stams, T.
登録日2020-08-21
公開日2020-09-23
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.166 Å)
主引用文献Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer.
J.Med.Chem., 63, 2020

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件を2024-08-21に公開中

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