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Structure of full-length human lambda-6A light chain JTO in complex with stabilizer 26 [2-(7-(diethylamino)-4-methyl-2-oxo-2H-chromen-3-yl)ethyl (3-(1H-imidazol-4-yl)benzyl)carbamate]
分子名称:	2-[7-(diethylamino)-4-methyl-2-oxidanylidene-chromen-3-yl]ethyl ~{N}-[[3-(1~{H}-imidazol-5-yl)phenyl]methyl]carbamate, JTO light chain, PHOSPHATE ION
著者	Yan, N.L, Wilson, I.A, Kelly, J.W.
登録日	2021-02-05
公開日	2021-05-19
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (2.01 Å)
主引用文献	Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design. J.Med.Chem., 64, 2021

3P3S

Human transthyretin (TTR) complexed with (Z)-5-(3,5-dibromo-4-hydroxybenzylidene)-imino-1-methylimidazolidin-4-one
分子名称:	(5Z)-2-amino-5-(3,5-dibromo-4-hydroxybenzylidene)-1-methyl-1,5-dihydro-4H-imidazol-4-one, Transthyretin
著者	Connelly, S, Wilson, I.A.
登録日	2010-10-05
公開日	2011-08-24
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (1.6 Å)
主引用文献	Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity. Sci Transl Med, 3, 2011

3P3U

Human transthyretin (TTR) complexed with 5-(2-ethoxyphenyl)-3-(pyridin-4-yl)-1,2,4-oxadiazole
分子名称:	4-[5-(2-ethoxyphenyl)-1,2,4-oxadiazol-3-yl]pyridine, Transthyretin
著者	Connelly, S, Wilson, I.A.
登録日	2010-10-05
公開日	2011-08-24
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (1.5 Å)
主引用文献	Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity. Sci Transl Med, 3, 2011

3P3T

Human transthyretin (TTR) complexed with 4-(3-(2-flourophenoxy)propyl)-3,5-dimethyl-1H-pyrazole
分子名称:	4-[3-(2-fluorophenoxy)propyl]-3,5-dimethyl-1H-pyrazole, Transthyretin
著者	Connelly, S, Wilson, I.A.
登録日	2010-10-05
公開日	2011-08-24
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (1.45 Å)
主引用文献	Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity. Sci Transl Med, 3, 2011

3P3R

Transthyretin in complex with (3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)methanone
分子名称:	(3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)methanone, Transthyretin
著者	Connelly, S, Wilson, I.A.
登録日	2010-10-05
公開日	2011-08-24
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (1.25 Å)
主引用文献	Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity. Sci Transl Med, 3, 2011

5CCK

Crystal structure of Human anti-HIV-1 broadly neutralizing antibody 3BC315 Fab
分子名称:	3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Antibody 3BC315 Fab heavy chain, Antibody 3BC315 Fab light chain
著者	Lee, J.H, Ward, A.B, Wilson, I.A.
登録日	2015-07-02
公開日	2015-10-07
最終更新日	2019-12-11
実験手法	X-RAY DIFFRACTION (1.95 Å)
主引用文献	Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike. Nat Commun, 6, 2015

5CJQ

Crystal structure of a trimeric influenza hemagglutinin stem in complex with an broadly neutralizing antibody CR9114
分子名称:	CR9114 heavy chain, CR9114 light chain, Designed influenza hemagglutinin stem #4900, ...
著者	Zhu, X, Wilson, I.A.
登録日	2015-07-14
公開日	2015-09-09
最終更新日	2015-09-30
実験手法	X-RAY DIFFRACTION (3.6 Å)
主引用文献	A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen. Science, 349, 2015

5CJS

Crystal structure of a monomeric influenza hemagglutinin stem in complex with an broadly neutralizing antibody CR9114
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, CR9114 heavy chain, CR9114 light chain, ...
著者	Zhu, X, Wilson, I.A.
登録日	2015-07-15
公開日	2015-09-09
最終更新日	2020-07-29
実験手法	X-RAY DIFFRACTION (4.3 Å)
主引用文献	A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen. Science, 349, 2015

5E2Y

Crystal structure of H5 hemagglutinin Q226L mutant from the influenza virus A/duck/Egypt/10185SS/2010 (H5N1)
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, beta-L-fucopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者	Zhu, X, Wilson, I.A.
登録日	2015-10-01
公開日	2015-12-02
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	Structural Basis for a Switch in Receptor Binding Specificity of Two H5N1 Hemagglutinin Mutants. Cell Rep, 13, 2015

5E32

Crystal structure of H5 hemagglutinin mutant (N224K, Q226L, N158D and L133a deletion) from the influenza virus A/chicken/Vietnam/NCVD-093/2008 (H5N1)
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin
著者	Zhu, X, Wilson, I.A.
登録日	2015-10-01
公開日	2015-12-02
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	Structural Basis for a Switch in Receptor Binding Specificity of Two H5N1 Hemagglutinin Mutants. Cell Rep, 13, 2015

5E99

Bovine Fab fragment F08_B11
分子名称:	Fab F08_B11 heavy chain, Fab F08_B11 light chain
著者	Stanfield, R.L, Wilson, I.A.
登録日	2015-10-14
公開日	2016-08-24
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.06 Å)
主引用文献	Conservation and diversity in the ultralong third heavy-chain complementarity-determining region of bovine antibodies. Sci Immunol, 1, 2016

1IAO

CLASS II MHC I-AD IN COMPLEX WITH OVALBUMIN PEPTIDE 323-339
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, MHC CLASS II I-AD
著者	Scott, C.A, Peterson, P.A, Teyton, L, Wilson, I.A.
登録日	1998-03-13
公開日	1998-11-04
最終更新日	2023-08-09
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	Crystal structures of two I-Ad-peptide complexes reveal that high affinity can be achieved without large anchor residues. Immunity, 8, 1998

5E34

Crystal structure of H5 hemagglutinin mutant (N224K, Q226L, N158D and L133a deletion) from the influenza virus A/chicken/Vietnam/NCVD-093/2008 (H5N1) with LSTa
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者	Zhu, X, Wilson, I.A.
登録日	2015-10-01
公開日	2015-12-02
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	Structural Basis for a Switch in Receptor Binding Specificity of Two H5N1 Hemagglutinin Mutants. Cell Rep, 13, 2015

5E35

Crystal structure of H5 hemagglutinin mutant (N224K, Q226L, N158D and L133a deletion) from the influenza virus A/chicken/Vietnam/NCVD-093/2008 (H5N1) with LSTc
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者	Zhu, X, Wilson, I.A.
登録日	2015-10-01
公開日	2015-12-02
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	Structural Basis for a Switch in Receptor Binding Specificity of Two H5N1 Hemagglutinin Mutants. Cell Rep, 13, 2015

2IGF

CRYSTAL STRUCTURES OF AN ANTIBODY TO A PEPTIDE AND ITS COMPLEX WITH PEPTIDE ANTIGEN AT 2.8 ANGSTROMS
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, IGG1-KAPPA B13I2 FAB (HEAVY CHAIN), IGG1-KAPPA B13I2 FAB (LIGHT CHAIN), ...
著者	Stanfield, R.L, Wilson, I.A.
登録日	1991-03-21
公開日	1992-04-15
最終更新日	2020-07-29
実験手法	X-RAY DIFFRACTION (2.8 Å)
主引用文献	Crystal structures of an antibody to a peptide and its complex with peptide antigen at 2.8 A. Science, 248, 1990

5E30

Crystal structure of H5 hemagglutinin Q226L mutant from the influenza virus A/duck/Egypt/10185SS/2010 (H5N1) with LSTc
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose, ...
著者	Zhu, X, Wilson, I.A.
登録日	2015-10-01
公開日	2015-12-02
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	Structural Basis for a Switch in Receptor Binding Specificity of Two H5N1 Hemagglutinin Mutants. Cell Rep, 13, 2015

5E2Z

Crystal structure of H5 hemagglutinin Q226L mutant from the influenza virus A/duck/Egypt/10185SS/2010 (H5N1) with LSTa
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose, ...
著者	Zhu, X, Wilson, I.A.
登録日	2015-10-01
公開日	2015-12-02
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.624 Å)
主引用文献	Structural Basis for a Switch in Receptor Binding Specificity of Two H5N1 Hemagglutinin Mutants. Cell Rep, 13, 2015

5C7K

Crystal structure BG505 SOSIP gp140 HIV-1 Env trimer bound to broadly neutralizing antibodies PGT128 and 8ANC195
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Fab 8ANC195 heavy chain, ...
著者	Kong, L, Stanfield, R.L, Wilson, I.A.
登録日	2015-06-24
公開日	2015-10-07
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (4.6019 Å)
主引用文献	Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer. Acta Crystallogr.,Sect.D, 71, 2015

5CEX

Crystal Structure of Fab 32H+109L, a putative precursor of the PGT121 family of potent HIV-1 antibodies
分子名称:	Antibody 9H+3L Fab heavy chain, Antibody 9H+3L Fab light chain, GLYCEROL, ...
著者	Garces, F, Wilson, I.A.
登録日	2015-07-07
公開日	2015-12-23
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.105 Å)
主引用文献	Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans. Immunity, 43, 2015

5BZD

Crystal Structure of PCDN-27A, an antibody from the PCDN family of HIV-1 antibodies
分子名称:	5G8 HIV Antibody heavy chain, 5G8 HIV Antibody light chain, GLYCEROL
著者	Garces, F, WILSON, I.A.
登録日	2015-06-11
公開日	2016-05-25
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	Early Antibody Lineage Diversification and Independent Limb Maturation Lead to Broad HIV-1 Neutralization Targeting the Env High-Mannose Patch Immunity, 44, 2016

5BZW

Crystal Structure of PCDN-27B, an antibody from the PCDN family of HIV-1 antibodies
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2B3 HIV Antibody heavy chain, 2B3 HIV Antibody light chain, ...
著者	Garces, F, WILSON, I.A.
登録日	2015-06-11
公開日	2016-05-25
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.9 Å)
主引用文献	Early Antibody Lineage Diversification and Independent Limb Maturation Lead to Broad HIV-1 Neutralization Targeting the Env High-Mannose Patch. Immunity, 44, 2016

3MJ7

Crystal structure of the complex of JAML and Coxsackie and Adenovirus receptor, CAR
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Coxsackievirus and adenovirus receptor homolog, ...
著者	Verdino, P, Wilson, I.A.
登録日	2010-04-12
公開日	2010-09-22
最終更新日	2020-07-29
実験手法	X-RAY DIFFRACTION (2.8 Å)
主引用文献	The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K. Science, 329, 2010

3MJ6

Crystal structure of the gammadelta T cell costimulatory receptor Junctional Adhesion Molecule-Like Protein, JAML
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, FORMIC ACID, Junctional adhesion molecule-like, ...
著者	Verdino, P, Wilson, I.A.
登録日	2010-04-12
公開日	2010-09-22
最終更新日	2024-04-03
実験手法	X-RAY DIFFRACTION (2.19 Å)
主引用文献	The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K. Science, 329, 2010

6W00

Crystal structure of Fab239 in complex with NPNA2 peptide from circumsporozoite protein
分子名称:	Fab239 heavy chain, Fab239 light chain, Immunoglobulin G-binding protein G, ...
著者	Pholcharee, T, Oyen, D, Wilson, I.A.
登録日	2020-02-28
公開日	2020-07-29
最終更新日	2024-04-03
実験手法	X-RAY DIFFRACTION (1.853 Å)
主引用文献	Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum. Nat Commun, 12, 2021

6WFX

Crystal structure of Fab395 in complex with NPNA2 peptide from circumsporozoite protein
分子名称:	Fab395 heavy chain, Fab395 light chain, NPNA2 peptide
著者	Pholcharee, T, Oyen, D, Wilson, I.A.
登録日	2020-04-04
公開日	2020-07-29
最終更新日	2024-04-03
実験手法	X-RAY DIFFRACTION (2.59 Å)
主引用文献	Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum. Nat Commun, 12, 2021

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