3MJ7

Crystal structure of the complex of JAML and Coxsackie and Adenovirus receptor, CAR

Summary for 3MJ7

• Entry DOI: 10.2210/pdb3mj7/pdb
• Related: 3MJ6 3MJ8 3MJ9
• Descriptor: Junctional adhesion molecule-like, Coxsackievirus and adenovirus receptor homolog, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: immunoglobulin tandem domain, immune receptor complex, cell adhesion, cell junction, glycoprotein, immunoglobulin domain, membrane, transmembrane, costimulation, phosphoprotein, receptor, secreted, tight junction, immune system
• Biological source: Mus musculus (mouse); More
• Cellular location: Cell junction (By similarity): Q80UL9; Isoform 1: Cell membrane; Single-pass type I membrane protein (By similarity). Isoform 2: Cell membrane; Single-pass type I membrane protein (By similarity). Isoform 3: Secreted (By similarity): P97792
• Total number of polymer chains: 2
• Total formula weight: 57234.05

Authors

Verdino, P.,Wilson, I.A. (deposition date: 2010-04-12, release date: 2010-09-22, Last modification date: 2020-07-29)

• Primary citation: Verdino, P.,Witherden, D.A.,Havran, W.L.,Wilson, I.A.; The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K.; Science, 329:1210-1214, 2010; PubMed: 20813955; DOI: 10.1126/science.1187996

Experimental method

X-RAY DIFFRACTION (2.8 Å)