4EJE
 
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6MVL
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6MVQ
 | | HCV NS5B 1b N316 bound to Compound 31 | | 分子名称: | (4-{1-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]-1H-1,2,4-triazol-5-yl}-2-fluorophenyl)boronic acid, HCV Polymerase | | 著者 | Williams, S.P, Kahler, K, Price, D.J, Peat, A.J. | | 登録日 | 2018-10-26 | | 公開日 | 2019-09-04 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | | 主引用文献 | Design of N-Benzoxaborole Benzofuran GSK8175-Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor.
J.Med.Chem., 62, 2019
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5MSL
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2ZAF
 | | Mechanistic and Structural Analyses of the Roles of Arg409 and Asp402 in the Reaction of the Flavoprotein Nitroalkane Oxidase | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Nitroalkane oxidase | | 著者 | Fitzpatrick, P.F, Bozinovski, D.M, Heroux, A, Shaw, P.G, Valley, M.P, Orville, A.M. | | 登録日 | 2007-10-05 | | 公開日 | 2008-06-03 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Mechanistic and structural analyses of the roles of Arg409 and Asp402 in the reaction of the flavoprotein nitroalkane oxidase.
Biochemistry, 46, 2007
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3SQO
 | | PCSK9 J16 Fab complex | | 分子名称: | J16 Heavy chain, J16 Light chain, PCSK9 prodomain, ... | | 著者 | Strop, P. | | 登録日 | 2011-07-05 | | 公開日 | 2012-05-16 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Proprotein convertase substilisin/kexin type 9 antagonism reduces low-density lipoprotein cholesterol in statin-treated hypercholesterolemic nonhuman primates.
J.Pharmacol.Exp.Ther., 340, 2012
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7LVK
 | | Cfr-modified 50S subunit from Escherichia coli | | 分子名称: | 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | | 著者 | Stojkovic, V, Myasnikov, A.G, Frost, A, Fujimori, D.G. | | 登録日 | 2021-02-25 | | 公開日 | 2021-12-15 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | | 主引用文献 | Investigating antibiotic resistance of a ribosomal-RNA methylating enzyme through directed evolution
To Be Published
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4L0M
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4KN5
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7KGM
 | | C. rodentium YcbB - ertapenem complex | | 分子名称: | (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, Putative exported protein | | 著者 | Caveney, N.A, Strynadka, N.C.J. | | 登録日 | 2020-10-17 | | 公開日 | 2020-11-25 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural and Cellular Insights into the l,d-Transpeptidase YcbB as a Therapeutic Target in Citrobacter rodentium, Salmonella Typhimurium, and Salmonella Typhi Infections.
Antimicrob.Agents Chemother., 65, 2021
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1CL5
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7KQL
 | | Anti-Tim3 antibody Fab complex | | 分子名称: | GLYCEROL, Hepatitis A virus cellular receptor 2, Tim3.18 Fab heavy chain, ... | | 著者 | Deng, X.A, West, S.M, Strop, P. | | 登録日 | 2020-11-16 | | 公開日 | 2022-02-09 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | | 主引用文献 | Tim-3 mediates T cell trogocytosis to limit antitumor immunity.
J.Clin.Invest., 132, 2022
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7CBS
 | | Crystal structure of SpaB basal pilin from Lactobacillus rhamnosus GG | | 分子名称: | CHLORIDE ION, LPXTG cell wall anchor domain-containing protein, MAGNESIUM ION | | 著者 | Megta, A.K, Pratap, S, Kant, A, Krishnan, V. | | 登録日 | 2020-06-13 | | 公開日 | 2020-12-30 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | | 主引用文献 | Crystal structure of the atypically adhesive SpaB basal pilus subunit: Mechanistic insights about its incorporation in lactobacillar SpaCBA pili.
Curr Res Struct Biol, 2, 2020
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2REH
 | | Mechanistic and Structural Analyses of the Roles of Arg409 and Asp402 in the Reaction of the Flavoprotein Nitroalkane Oxidase | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Nitroalkane oxidase | | 著者 | Fitzpatrick, P.F, Bozinovski, D.M, Heroux, A, Shaw, P.G, Valley, M.P, Orville, A.M. | | 登録日 | 2007-09-26 | | 公開日 | 2008-06-03 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Mechanistic and structural analyses of the roles of Arg409 and Asp402 in the reaction of the flavoprotein nitroalkane oxidase.
Biochemistry, 46, 2007
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3FCJ
 | | Nitroalkane oxidase: mutant402N crystallized with nitroethane | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Nitroalkane oxidase, ... | | 著者 | Major, D.T, Gao, J, Heroux, A, Orville, A.M, Valley, M.P, Fitzpatrick, P.F. | | 登録日 | 2008-11-21 | | 公開日 | 2009-11-03 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Differential quantum tunneling contributions in nitroalkane oxidase catalyzed and the uncatalyzed proton transfer reaction.
Proc.Natl.Acad.Sci.USA, 106, 2009
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6XZA
 | | E. coli 70S ribosome in complex with dirithromycin, and deacylated tRNA(iMet) (focused classification). | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Pichkur, E.B, Polikanov, Y.S, Myasnikov, A.G, Konevega, A.L. | | 登録日 | 2020-02-03 | | 公開日 | 2020-11-04 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (2.66 Å) | | 主引用文献 | Insights into the improved macrolide inhibitory activity from the high-resolution cryo-EM structure of dirithromycin bound to the E. coli 70S ribosome.
Rna, 26, 2020
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6XZB
 | | E. coli 70S ribosome in complex with dirithromycin, fMet-Phe-tRNA(Phe) and deacylated tRNA(iMet) (focused classification). | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Pichkur, E.B, Polikanov, Y.S, Myasnikov, A.G, Konevega, A.L. | | 登録日 | 2020-02-03 | | 公開日 | 2020-11-04 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (2.54 Å) | | 主引用文献 | Insights into the improved macrolide inhibitory activity from the high-resolution cryo-EM structure of dirithromycin bound to the E. coli 70S ribosome.
Rna, 26, 2020
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6XZ7
 | | E. coli 50S ribosomal subunit in complex with dirithromycin, fMet-Phe-tRNA(Phe) and deacylated tRNA(iMet). | | 分子名称: | 23S rRNA, 50S ribosomal protein L10, 50S ribosomal protein L11, ... | | 著者 | Pichkur, E.B, Polikanov, Y.S, Myasnikov, A.G, Konevega, A.L. | | 登録日 | 2020-02-03 | | 公開日 | 2020-07-22 | | 実験手法 | ELECTRON MICROSCOPY (2.1 Å) | | 主引用文献 | Insights into the improved macrolide inhibitory activity from the high-resolution cryo-EM structure of dirithromycin bound to theE. coli70S ribosome.
Rna, 26, 2020
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8U0Q
 | | Co-crystal structure of optimized analog TDI-13537 provided new insights into the potency determinants of the sulfonamide inhibitor series | | 分子名称: | Dihydrolipoyl dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | | 著者 | Dementiev, A.A, Michino, M, Vendome, J, Ginn, J, Bryk, R, Olland, A. | | 登録日 | 2023-08-29 | | 公開日 | 2024-01-03 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | Shape-Based Virtual Screening of a Billion-Compound Library Identifies Mycobacterial Lipoamide Dehydrogenase Inhibitors.
Acs Bio Med Chem Au, 3, 2023
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7SU0
 | | Crystal structure of an acidic pH-selective Ipilimumab variant Ipi.105 in complex with CTLA-4 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CITRATE ANION, Cytotoxic T-lymphocyte protein 4, ... | | 著者 | Lee, P.S, Chau, B, Strop, P. | | 登録日 | 2021-11-15 | | 公開日 | 2022-03-02 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | | 主引用文献 | Improved therapeutic index of an acidic pH-selective antibody.
Mabs, 14, 2022
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5HLP
 | | X-RAY CRYSTAL STRUCTURE OF GSK3B IN COMPLEX WITH BRD3937 | | 分子名称: | 4-(2-methoxyphenyl)-3,7,7-trimethyl-1,6,7,8-tetrahydro-5H-pyrazolo[3,4-b]quinolin-5-one, Glycogen synthase kinase-3 beta | | 著者 | White, A, Lakshminarasimhan, D, Nadupalli, A, Suto, R.K. | | 登録日 | 2016-01-15 | | 公開日 | 2016-05-25 | | 最終更新日 | 2016-07-27 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects.
Acs Chem.Biol., 11, 2016
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5HLN
 | | X-RAY CRYSTAL STRUCTURE OF GSK3B IN COMPLEX WITH CHIR99021 | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHIR99021, Glycogen synthase kinase-3 beta, ... | | 著者 | White, A, Lakshminarasimhan, D, Nadupalli, A, Suto, R.K. | | 登録日 | 2016-01-15 | | 公開日 | 2016-05-25 | | 最終更新日 | 2016-07-27 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects.
Acs Chem.Biol., 11, 2016
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8EKC
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8EKB
 | | Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, deacylated P-site tRNAmet, and thermorubin at 2.70A resolution | | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Paranjpe, M.N, Polikanov, Y.S. | | 登録日 | 2022-09-20 | | 公開日 | 2022-12-21 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Insights into the molecular mechanism of translation inhibition by the ribosome-targeting antibiotic thermorubin.
Nucleic Acids Res., 51, 2023
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2GNV
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