8EKB
Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, deacylated P-site tRNAmet, and thermorubin at 2.70A resolution
This is a non-PDB format compatible entry.
Summary for 8EKB
| Entry DOI | 10.2210/pdb8ekb/pdb |
| Descriptor | 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (60 entities in total) |
| Functional Keywords | ribosome, antibiotic, thermorubin, trna, release factor, rapid kinetics, thermodynamics |
| Biological source | Escherichia coli More |
| Total number of polymer chains | 108 |
| Total formula weight | 4463029.65 |
| Authors | Paranjpe, M.N.,Polikanov, Y.S. (deposition date: 2022-09-20, release date: 2022-12-21, Last modification date: 2023-11-15) |
| Primary citation | Paranjpe, M.N.,Marina, V.I.,Grachev, A.A.,Maviza, T.P.,Tolicheva, O.A.,Paleskava, A.,Osterman, I.A.,Sergiev, P.V.,Konevega, A.L.,Polikanov, Y.S.,Gagnon, M.G. Insights into the molecular mechanism of translation inhibition by the ribosome-targeting antibiotic thermorubin. Nucleic Acids Res., 51:449-462, 2023 Cited by PubMed: 36546783DOI: 10.1093/nar/gkac1189 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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