Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6MVQ

HCV NS5B 1b N316 bound to Compound 31

Summary for 6MVQ
Entry DOI10.2210/pdb6mvq/pdb
Related6MVK 6MVO 6MVP
DescriptorHCV Polymerase, (4-{1-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]-1H-1,2,4-triazol-5-yl}-2-fluorophenyl)boronic acid (3 entities in total)
Functional Keywordshepatitus c, ns5b, replication, viral protein
Biological sourceHepatitis C virus subtype 1b
Total number of polymer chains2
Total formula weight125985.79
Authors
Williams, S.P.,Kahler, K.,Price, D.J.,Peat, A.J. (deposition date: 2018-10-26, release date: 2019-09-04, Last modification date: 2024-03-13)
Primary citationChong, P.Y.,Shotwell, J.B.,Miller, J.,Price, D.J.,Maynard, A.,Voitenleitner, C.,Mathis, A.,Williams, S.,Pouliot, J.J.,Creech, K.,Wang, F.,Fang, J.,Zhang, H.,Tai, V.W.,Turner, E.,Kahler, K.M.,Crosby, R.,Peat, A.J.
Design of N-Benzoxaborole Benzofuran GSK8175-Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor.
J.Med.Chem., 62:3254-3267, 2019
Cited by
PubMed: 30763090
DOI: 10.1021/acs.jmedchem.8b01719
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.14 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon