6MVQ
HCV NS5B 1b N316 bound to Compound 31
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | HCV Polymerase | polymer | 563 | 62478.6 | 2 | UniProt (Q99AU2) Pfam (PF00998) In PDB | Hepatitis C virus subtype 1b | |
| 2 | A, B | (4-{1-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]-1H-1,2,4-triazol-5-yl}-2-fluorophenyl)boronic acid | non-polymer | 514.3 | 2 | Chemie (K4M) | |||
| 3 | water | water | 18.0 | 446 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 563 (UniProt: Q99AU2)
| PDB | External Database | Details |
|---|---|---|
| Gln 47 | Leu 2466 | conflict |
| Tyr 101 | Phe 2520 | engineered mutation |
| Arg 114 | Lys 2533 | engineered mutation |
| Ala 149 | Pro 2568 | conflict |
| Val 329 | Thr 2748 | conflict |
| Arg 544 | Gln 2963 | conflict |
| Ala 563 | Ser 2982 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 124957.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1028.6 | |
| All* | Total formula weight | 125985.8 |
