Search by PDB author

Crystal structure of a humanized (K18E, K269N) rat succinate receptor SUCNR1 (GPR91) in complex with a nanobody and antagonist
分子名称:	(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-[2-[[3-[4-chloranyl-2-fluoranyl-5-[(3~{R})-piperidin-3-yl]oxy-phenyl]-2-fluoranyl-phenyl]carbonylamino]-5-fluoranyl-phenyl]ethanoic acid, CHLORIDE ION, ...
著者	Haffke, M, Villard, F.
登録日	2020-05-11
公開日	2020-09-16
最終更新日	2024-01-24
実験手法	X-RAY DIFFRACTION (2.269 Å)
主引用文献	Discovery and Optimization of Novel SUCNR1 Inhibitors: Design of Zwitterionic Derivatives with a Salt Bridge for the Improvement of Oral Exposure. J.Med.Chem., 63, 2020

3FBX

Crystal structure of the lysosomal 66.3 kDa protein from mouse solved by S-SAD
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ...
著者	Lakomek, K, Dickmanns, A, Mueller, U, Ficner, R.
登録日	2008-11-20
公開日	2009-03-03
最終更新日	2023-12-27
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	De novo sulfur SAD phasing of the lysosomal 66.3 kDa protein from mouse Acta Crystallogr.,Sect.D, 65, 2009

5BNJ

CDK8/CYCC IN COMPLEX WITH 8-{3-Chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)-phenyl]-pyridin- 4-yl}-2,8-diaza-spiro[4.5]decan-1-one
分子名称:	8-{3-chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]pyridin-4-yl}-2,8-diazaspiro[4.5]decan-1-one, Cyclin-C, Cyclin-dependent kinase 8, ...
著者	Musil, D, Blagg, J, Wienke, D.
登録日	2015-05-26
公開日	2015-10-14
最終更新日	2024-05-08
実験手法	X-RAY DIFFRACTION (2.64 Å)
主引用文献	A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease. Nat.Chem.Biol., 11, 2015

6Q7A

RORCVAR2 (RORGT, 264-499) IN COMPLEX WITH COMPOUND 4 AT 2.2A: Identification of N-aryl imidazoles as potent and selective RORgt inhibitors
分子名称:	1-[2,6-bis(chloranyl)phenyl]-2-(furan-2-yl)-5-methyl-4-(phenylmethyl)imidazole, Nuclear receptor ROR-gamma
著者	Kallen, J.
登録日	2018-12-13
公開日	2019-11-27
最終更新日	2024-01-24
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Structure-Based and Property-Driven Optimization ofN-Aryl Imidazoles toward Potent and Selective Oral ROR gamma t Inhibitors. J.Med.Chem., 62, 2019

6FZU

RORGT (264-518;C455S) IN COMPLEX WITH THE FRAGMENT ("CPD-1") AND RIP140 PEPTIDE AT 1.80A
分子名称:	Nuclear receptor ROR-gamma, Nuclear receptor-interacting protein 1, ~{N}-(3-chloranyl-4-ethoxy-phenyl)ethanamide
著者	Kallen, J.
登録日	2018-03-15
公開日	2018-07-18
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Optimizing a Weakly Binding Fragment into a Potent ROR gamma t Inverse Agonist with Efficacy in an in Vivo Inflammation Model. J. Med. Chem., 61, 2018

6Q6O

RORCVAR2 (RORGT, 264-499) IN COMPLEX WITH COMPOUND 2 AT 2.3A: Identification of N-aryl imidazoles as potent and selective RORgt inhibitors
分子名称:	CHOLIC ACID, Nuclear receptor ROR-gamma, propan-2-yl (2~{S})-2-[[2,6-bis(chloranyl)phenyl]-(furan-2-ylcarbonyl)amino]propanoate
著者	Kallen, J.
登録日	2018-12-11
公開日	2019-11-27
最終更新日	2024-01-24
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Structure-Based and Property-Driven Optimization ofN-Aryl Imidazoles toward Potent and Selective Oral ROR gamma t Inhibitors. J.Med.Chem., 62, 2019

6Q7H

RORCVAR2 (RORGT, 264-499) IN COMPLEX WITH COMPOUND 9 AT 2.3A: Identification of N-aryl imidazoles as potent and selective RORgt inhibitors
分子名称:	1-[2,4-bis(chloranyl)-3-[2-(5-chloranylfuran-2-yl)-5-methyl-4-(trifluoromethyl)imidazol-1-yl]phenyl]azetidine-3-carboxylic acid, Nuclear receptor ROR-gamma
著者	Kallen, J.
登録日	2018-12-13
公開日	2019-11-27
最終更新日	2024-01-24
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Structure-Based and Property-Driven Optimization ofN-Aryl Imidazoles toward Potent and Selective Oral ROR gamma t Inhibitors. J.Med.Chem., 62, 2019

6G07

RORGT (264-518;C455S) IN COMPLEX WITH INVERSE AGONIST "CPD-9" AND RIP140 PEPTIDE AT 1.66A
分子名称:	Nuclear receptor ROR-gamma, Nuclear receptor-interacting protein 1, ~{N}-[5-chloranyl-6-[(1~{S})-1-phenylethoxy]pyridin-3-yl]-2-(4-ethylsulfonylphenyl)ethanamide
著者	Kallen, J.
登録日	2018-03-16
公開日	2018-07-18
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (1.66 Å)
主引用文献	Optimizing a Weakly Binding Fragment into a Potent ROR gamma t Inverse Agonist with Efficacy in an in Vivo Inflammation Model. J. Med. Chem., 61, 2018

6Q6M

RORCVAR2 (RORGT, 264-499) IN COMPLEX WITH COMPOUND 1: Identification of N-aryl imidazoles as potent and selective RORgt inhibitors
分子名称:	Nuclear receptor ROR-gamma, ethyl (2~{S})-2-[(2-chloranyl-6-methyl-phenyl)-thiophen-2-ylcarbonyl-amino]propanoate
著者	Kallen, J.
登録日	2018-12-11
公開日	2019-11-27
最終更新日	2024-01-24
実験手法	X-RAY DIFFRACTION (2.35 Å)
主引用文献	Structure-Based and Property-Driven Optimization ofN-Aryl Imidazoles toward Potent and Selective Oral ROR gamma t Inhibitors. J.Med.Chem., 62, 2019

6G05

RORGT (264-518;C455S) IN COMPLEX WITH INVERSE AGONIST "CPD-2" AND RIP140 PEPTIDE AT 1.90A
分子名称:	2-(4-ethylsulfonylphenyl)-~{N}-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yl]ethanamide, Nuclear receptor ROR-gamma, Nuclear receptor-interacting protein 1
著者	Kallen, J.
登録日	2018-03-16
公開日	2018-07-18
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Optimizing a Weakly Binding Fragment into a Potent ROR gamma t Inverse Agonist with Efficacy in an in Vivo Inflammation Model. J. Med. Chem., 61, 2018

5N12

Crystal structure of TCE treated rPPEP-1
分子名称:	2,2,2-tris-chloroethanol, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Pro-Pro endopeptidase, ...
著者	Pichlo, C, Schacherl, M, Baumann, U.
登録日	2017-02-04
公開日	2018-05-30
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (1.38 Å)
主引用文献	Improved protein-crystal identification by using 2,2,2-trichloroethanol as a fluorescence enhancer. Acta Crystallogr F Struct Biol Commun, 74, 2018

7LG6

BG505 SOSIP.v5.2 in complex with VRC40.01 and RM19R Fabs
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ...
著者	Cottrell, C.A, Torres, J.L, Wu, N.R, Ward, A.B.
登録日	2021-01-19
公開日	2021-09-15
最終更新日	2021-11-17
実験手法	ELECTRON MICROSCOPY (3.28 Å)
主引用文献	Structural basis of glycan276-dependent recognition by HIV-1 broadly neutralizing antibodies. Cell Rep, 37, 2021

1YNA

ENDO-1,4-BETA-XYLANASE, ROOM TEMPERATURE, PH 4.0
分子名称:	ENDO-1,4-BETA-XYLANASE
著者	Gruber, K, Kratky, C.
登録日	1996-08-22
公開日	1997-02-12
最終更新日	2019-12-25
実験手法	X-RAY DIFFRACTION (1.55 Å)
主引用文献	Thermophilic xylanase from Thermomyces lanuginosus: high-resolution X-ray structure and modeling studies. Biochemistry, 37, 1998

6ZHY

Cryo-EM structure of the regulatory linker of ALC1 bound to the nucleosome's acidic patch: hexasome class.
分子名称:	Chromodomain-helicase-DNA-binding protein 1-like, DNA (110-MER) Widom 601 sequence, Histone H2A type 1, ...
著者	Bacic, L, Gaullier, G, Deindl, S.
登録日	2020-06-24
公開日	2020-12-23
最終更新日	2024-07-10
実験手法	ELECTRON MICROSCOPY (3 Å)
主引用文献	Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch. Cell Rep, 33, 2020

6ZHX

Cryo-EM structure of the regulatory linker of ALC1 bound to the nucleosome's acidic patch: nucleosome class.
分子名称:	Chromodomain-helicase-DNA-binding protein 1-like, DNA (145-MER) Widom 601 sequence, Histone H2A type 1, ...
著者	Bacic, L, Gaullier, G, Croll, T.I, Deindl, S.
登録日	2020-06-24
公開日	2020-12-23
最終更新日	2024-07-10
実験手法	ELECTRON MICROSCOPY (2.5 Å)
主引用文献	Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch. Cell Rep, 33, 2020

1KNU

LIGAND BINDING DOMAIN OF THE HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA IN COMPLEX WITH A SYNTHETIC AGONIST
分子名称:	(S)-3-(4-(2-CARBAZOL-9-YL-ETHOXY)-PHENYL)-2-ETHOXY-PROPIONIC ACID, PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA
著者	Svensson, L.A, Mortensen, S.B, Fleckner, J, Woeldike, H.F.
登録日	2001-12-19
公開日	2002-12-19
最終更新日	2023-10-25
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity J.MED.CHEM., 45, 2002

3RBX

MthK RCK domain D184N mutant, Ca2+-bound
分子名称:	CALCIUM ION, Calcium-gated potassium channel mthK
著者	Samakai, E, Rothberg, B.S.
登録日	2011-03-30
公開日	2011-10-12
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (2.8 Å)
主引用文献	Structures of multiple Ca2+-binding sites in a K+ channel RCK domain Proc.Natl.Acad.Sci.USA, 2011

3RBZ

MthK channel, Ca2+-bound
分子名称:	CALCIUM ION, Calcium-gated potassium channel mthK
著者	Taylor, A.B, Parfenova, L.V, Rothberg, B.S.
登録日	2011-03-30
公開日	2011-10-12
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (3.4 Å)
主引用文献	Structures of multiple Ca2+-binding sites in a K+ channel RCK domain Proc.Natl.Acad.Sci.USA, 2011

6GX3

Crystal structure of Schistosoma mansoni HDAC8 complexed with an hydroxamate 1
分子名称:	4-chloranyl-~{N}-oxidanyl-1-benzothiophene-2-carboxamide, DIMETHYLFORMAMIDE, GLYCEROL, ...
著者	Shaik, T.B, Marek, M, Romier, C.
登録日	2018-06-26
公開日	2018-08-15
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as SmHDAC8 Inhibitors for the Treatment of Schistosomiasis. ChemMedChem, 13, 2018

6GXU

Crystal structure of Schistosoma mansoni HDAC8 complexed with an hydroxamate 3
分子名称:	(~{E})-3-[2-(4-chlorophenyl)sulfanylphenyl]-~{N}-oxidanyl-prop-2-enamide, DIMETHYLFORMAMIDE, GLYCEROL, ...
著者	Shaik, T.B, Marek, M, Romier, C.
登録日	2018-06-27
公開日	2018-08-15
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (1.917 Å)
主引用文献	Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as SmHDAC8 Inhibitors for the Treatment of Schistosomiasis. ChemMedChem, 13, 2018

6GXW

Crystal structure of Schistosoma mansoni HDAC8 complexed with an hydroxamate 4
分子名称:	(~{E})-3-[2-[[2,6-bis(chloranyl)phenyl]methoxy]phenyl]-~{N}-oxidanyl-prop-2-enamide, DIMETHYLFORMAMIDE, GLYCEROL, ...
著者	Shaik, T.B, Marek, M, Romier, C.
登録日	2018-06-27
公開日	2018-08-15
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (2.071 Å)
主引用文献	Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as SmHDAC8 Inhibitors for the Treatment of Schistosomiasis. ChemMedChem, 13, 2018

1ZWD

STRUCTURE OF HUMAN PARATHYROID HORMONE FRAGMENT 3-37, NMR, 10 STRUCTURES
分子名称:	PARATHYROID HORMONE
著者	Roesch, P, Marx, U.C.
登録日	1996-06-17
公開日	1997-03-12
最終更新日	2024-05-22
実験手法	SOLUTION NMR
主引用文献	Structure-activity relation of NH2-terminal human parathyroid hormone fragments. J.Biol.Chem., 273, 1998

1ZWA

STRUCTURE OF HUMAN PARATHYROID HORMONE FRAGMENT 1-34, NMR, 10 STRUCTURES
分子名称:	PARATHYROID HORMONE
著者	Roesch, P, Marx, U.C.
登録日	1996-06-17
公開日	1997-03-12
最終更新日	2024-05-22
実験手法	SOLUTION NMR
主引用文献	Solution structures of human parathyroid hormone fragments hPTH(1-34) and hPTH(1-39) and bovine parathyroid hormone fragment bPTH(1-37). Biochem.Biophys.Res.Commun., 267, 2000

1ZWE

STRUCTURE OF HUMAN PARATHYROID HORMONE FRAGMENT 4-37, NMR, 10 STRUCTURES
分子名称:	PARATHYROID HORMONE
著者	Roesch, P, Marx, U.C.
登録日	1996-06-17
公開日	1997-03-12
最終更新日	2024-05-22
実験手法	SOLUTION NMR
主引用文献	Structure-activity relation of NH2-terminal human parathyroid hormone fragments. J.Biol.Chem., 273, 1998

1ZWC

STRUCTURE OF BOVINE PARATHYROID HORMONE FRAGMENT 1-37, NMR, 10 STRUCTURES
分子名称:	PARATHYROID HORMONE
著者	Roesch, P, Marx, U.C.
登録日	1996-06-17
公開日	1997-03-12
最終更新日	2024-05-22
実験手法	SOLUTION NMR
主引用文献	Solution structures of human parathyroid hormone fragments hPTH(1-34) and hPTH(1-39) and bovine parathyroid hormone fragment bPTH(1-37). Biochem.Biophys.Res.Commun., 267, 2000

<6 7 8 9 10 11 121314 15 16 17 18 19 >

全ヒット件数:	475
表示件数:	25
表示順	関連性が高い順