6G05

RORGT (264-518;C455S) IN COMPLEX WITH INVERSE AGONIST "CPD-2" AND RIP140 PEPTIDE AT 1.90A

Summary for 6G05

• Entry DOI: 10.2210/pdb6g05/pdb
• Related: 6FZU
• Descriptor: Nuclear receptor ROR-gamma, Nuclear receptor-interacting protein 1, 2-(4-ethylsulfonylphenyl)-~{N}-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yl]ethanamide, ... (4 entities in total)
• Functional Keywords: fbs, nuclear hormone receptor, ligand-binding domain, inverse agonist, signaling protein, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 65099.05

Authors

Kallen, J. (deposition date: 2018-03-16, release date: 2018-07-18, Last modification date: 2024-01-17)

• Primary citation: Carcache, D.A.,Vulpetti, A.,Kallen, J.,Mattes, H.,Orain, D.,Stringer, R.,Vangrevelinghe, E.,Wolf, R.M.,Kaupmann, K.,Ottl, J.,Dawson, J.,Cooke, N.G.,Hoegenauer, K.,Billich, A.,Wagner, J.,Guntermann, C.,Hintermann, S.; Optimizing a Weakly Binding Fragment into a Potent ROR gamma t Inverse Agonist with Efficacy in an in Vivo Inflammation Model.; J. Med. Chem., 61:6724-6735, 2018; PubMed: 29990434; DOI: 10.1021/acs.jmedchem.8b00529

Experimental method

X-RAY DIFFRACTION (1.9 Å)