7LAP
| Crystal structure of aminoglycoside acetyltransferase AAC(3)-Xa | 分子名称: | Aminoglycoside N(3)-acetyltransferase, CHLORIDE ION, D(-)-TARTARIC ACID, ... | 著者 | Stogios, P.J, Skarina, T, Kim, Y, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2021-01-06 | 公開日 | 2021-02-03 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family. Commun Biol, 5, 2022
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8WW2
| GPR3/Gs complex | 分子名称: | CHOLESTEROL HEMISUCCINATE, G-protein coupled receptor 3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | He, Y, Xiong, Y. | 登録日 | 2023-10-24 | 公開日 | 2024-02-14 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.79 Å) | 主引用文献 | Identification of oleic acid as an endogenous ligand of GPR3. Cell Res., 34, 2024
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3O39
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3FYD
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7XAD
| Crystal strucutre of PD-L1 and DBL2_02 designed protein binder | 分子名称: | DBL2_02 binder, Programmed cell death 1 ligand 1 | 著者 | Liu, K.F, Xu, Z.P, Han, P, Pacesa, M, Gao, G.F, Chai, Y, Tan, S.G. | 登録日 | 2022-03-17 | 公開日 | 2023-04-12 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | De novo design of protein interactions with learned surface fingerprints. Nature, 617, 2023
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8KFX
| Gi bound CCR8 complex with nonpeptide agonist LMD-009 | 分子名称: | 8-[[3-(2-methoxyphenoxy)phenyl]methyl]-1-(2-phenylethyl)-1,3,8-triazaspiro[4.5]decan-4-one, C-C chemokine receptor type 8,Fusion protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Jiang, S, Lin, X, Wu, L.J, Xu, F. | 登録日 | 2023-08-16 | 公開日 | 2024-02-07 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | 主引用文献 | Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8. Sci Adv, 10, 2024
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8KFZ
| Gi bound CCR8 in ligand free state | 分子名称: | C-C chemokine receptor type 8,LgBiT fusion protein,Recombinant Human Rhinovirus, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Jiang, S, Lin, X, Wu, L.J, Xu, F. | 登録日 | 2023-08-16 | 公開日 | 2024-02-07 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8. Sci Adv, 10, 2024
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8KFY
| Gi bound CCR8 complex with nonpeptide agonist ZK 756326 | 分子名称: | 2-[2-[4-[(3-phenoxyphenyl)methyl]piperazin-1-yl]ethoxy]ethanol, C-C chemokine receptor type 8,Fusion protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Jiang, S, Lin, X, Wu, L.J, Xu, F. | 登録日 | 2023-08-16 | 公開日 | 2024-02-07 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8. Sci Adv, 10, 2024
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2KTM
| Solution NMR structure of H2H3 domain of ovine prion protein (residues 167-234) | 分子名称: | Major prion protein | 著者 | Pastore, A, Adrover, M, Pauwels, K, de Chiara, C, Prigent, S, Rezeai, H. | 登録日 | 2010-02-04 | 公開日 | 2010-04-07 | 最終更新日 | 2021-11-10 | 実験手法 | SOLUTION NMR | 主引用文献 | Prion fibrillization is mediated by a native structural element that comprises helices H2 and H3. J.Biol.Chem., 285, 2010
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3FYC
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8GW4
| SARS-CoV-2 Mpro 1-302/C145A in complex with peptide 8-1 | 分子名称: | Replicase polyprotein 1ab, peptide 8-1 | 著者 | Liu, M, Huang, H. | 登録日 | 2022-09-16 | 公開日 | 2023-08-23 | 最終更新日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | The S1'-S3' Pocket of the SARS-CoV-2 Main Protease Is Critical for Substrate Selectivity and Can Be Targeted with Covalent Inhibitors. Angew.Chem.Int.Ed.Engl., 62, 2023
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8IEJ
| RNF20-RNF40/hRad6A-Ub/nucleosome complex | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase BRE1A, E3 ubiquitin-protein ligase BRE1B, ... | 著者 | Ai, H, Deng, Z, Sun, M, Du, Y, Pan, M, Liu, L. | 登録日 | 2023-02-15 | 公開日 | 2023-09-06 | 最終更新日 | 2023-09-20 | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | 主引用文献 | Mechanistic insights into nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and its human homolog RNF20/RNF40-hRAD6A. Mol.Cell, 83, 2023
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8IEG
| Bre1(mRBD-RING)/Rad6-Ub/nucleosome complex | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase BRE1, Histone H2A type 1-B/E, ... | 著者 | Ai, H, Deng, Z, Pan, M, Liu, L. | 登録日 | 2023-02-15 | 公開日 | 2023-09-06 | 最終更新日 | 2023-09-20 | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | 主引用文献 | Mechanistic insights into nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and its human homolog RNF20/RNF40-hRAD6A. Mol.Cell, 83, 2023
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8U89
| The structure of the PP2A-B56Delta holoenzyme mutant - E197K | 分子名称: | MANGANESE (II) ION, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ... | 著者 | Wu, C.G, Xing, Y. | 登録日 | 2023-09-16 | 公開日 | 2024-01-10 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | B56 delta long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan's syndrome mutations. Proc.Natl.Acad.Sci.USA, 121, 2024
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8U1X
| The structure of the PP2A-B56Delta holoenzyme mutant - E197K | 分子名称: | MANGANESE (II) ION, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ... | 著者 | Wu, C.G, Xing, Y. | 登録日 | 2023-09-04 | 公開日 | 2024-01-17 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | B56 delta long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan's syndrome mutations. Proc.Natl.Acad.Sci.USA, 121, 2024
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8IYX
| Cryo-EM structure of the GPR34 receptor in complex with the antagonist YL-365 | 分子名称: | 1-[4-(3-chlorophenyl)phenyl]carbonyl-4-[2-(4-phenylmethoxyphenyl)ethanoylamino]piperidine-4-carboxylic acid, Probable G-protein coupled receptor 34,YL-365 | 著者 | Jia, G.W, Wang, X, Zhang, C.B, Dong, H.H, Su, Z.M. | 登録日 | 2023-04-06 | 公開日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | 主引用文献 | Cryo-EM structures of human GPR34 enable the identification of selective antagonists. Proc.Natl.Acad.Sci.USA, 120, 2023
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6ISV
| Structure of acetophenone reductase from Geotrichum candidum NBRC 4597 in complex with NAD | 分子名称: | Acetophenone reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ZINC ION | 著者 | Koesoema, A.A, Sugiyama, Y, Senda, M, Senda, T, Matsuda, T. | 登録日 | 2018-11-19 | 公開日 | 2019-09-11 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis for a highly (S)-enantioselective reductase towards aliphatic ketones with only one carbon difference between side chain. Appl.Microbiol.Biotechnol., 103, 2019
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8IFZ
| Cryo-EM structure of SARS-CoV-2 Omicron BA.4/5 spike protein receptor-binding domain in complex with white-tailed deer ACE2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, Spike protein S1, ... | 著者 | Han, P, Meng, Y.M, Qi, J.X. | 登録日 | 2023-02-20 | 公開日 | 2023-08-30 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | 主引用文献 | Structural basis of white-tailed deer, Odocoileus virginianus , ACE2 recognizing all the SARS-CoV-2 variants of concern with high affinity. J.Virol., 97, 2023
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8IFY
| Cryo-EM structure of SARS-CoV-2 Omicron BA.4/5 spike protein in complex with white-tailed deer ACE2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, ... | 著者 | Han, P, Meng, Y.M, Qi, J.X. | 登録日 | 2023-02-20 | 公開日 | 2023-08-30 | 最終更新日 | 2023-10-25 | 実験手法 | ELECTRON MICROSCOPY (2.55 Å) | 主引用文献 | Structural basis of white-tailed deer, Odocoileus virginianus , ACE2 recognizing all the SARS-CoV-2 variants of concern with high affinity. J.Virol., 97, 2023
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6MN3
| Crystal structure of aminoglycoside acetyltransferase AAC(3)-IVa, apoenzyme | 分子名称: | Aminoglycoside N(3)-acetyltransferase, AAC(3)-IVa, CHLORIDE ION, ... | 著者 | Stogios, P.J, Evdokimova, E, Wawrzak, Z, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2018-10-01 | 公開日 | 2018-10-24 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family. Commun Biol, 5, 2022
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8XK8
| N1D10 Fab bound to SFTSV glycoprotein-Gn | 分子名称: | Envelopment polyprotein, mAb N1D10 Fab heavy chain, mAb N1D10 Fab light chain | 著者 | Zhao, H, Deng, Z. | 登録日 | 2023-12-22 | 公開日 | 2024-07-10 | 最終更新日 | 2024-09-11 | 実験手法 | X-RAY DIFFRACTION (3.53 Å) | 主引用文献 | A broadly protective antibody targeting glycoprotein Gn inhibits severe fever with thrombocytopenia syndrome virus infection. Nat Commun, 15, 2024
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8XK5
| SNB1G11 Fab bound to SFTSV glycoprotein Gn | 分子名称: | Envelopment polyprotein, mAb SNB1G11 Fab heavy chain, mAb SNB1G11 Fab light chain | 著者 | Deng, Z. | 登録日 | 2023-12-22 | 公開日 | 2024-07-10 | 最終更新日 | 2024-09-11 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | A broadly protective antibody targeting glycoprotein Gn inhibits severe fever with thrombocytopenia syndrome virus infection. Nat Commun, 15, 2024
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6AKJ
| The crystal structure of EMC complex | 分子名称: | Enhancer of rudimentary homolog,YTH domain-containing protein mmi1 fusion protein, SULFATE ION | 著者 | Li, F. | 登録日 | 2018-09-01 | 公開日 | 2019-02-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | A conserved dimer interface connects ERH and YTH family proteins to promote gene silencing. Nat Commun, 10, 2019
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8XK6
| S2A5 Fab bound to SFTSV glycoprotein Gn | 分子名称: | Envelopment polyprotein, mAb S2A5 Fab heavy chain, mAb S2A5 Fab light chain | 著者 | Deng, Z. | 登録日 | 2023-12-22 | 公開日 | 2024-07-10 | 最終更新日 | 2024-09-11 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | A broadly protective antibody targeting glycoprotein Gn inhibits severe fever with thrombocytopenia syndrome virus infection. Nat Commun, 15, 2024
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7F2S
| Crystal structure of anti S-gatifloxacin antibody Fab fragment apo form | 分子名称: | 1,2-ETHANEDIOL, Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, ... | 著者 | Wang, L.T, Jiao, W.Y, Shen, X, Lei, H.T. | 登録日 | 2021-06-14 | 公開日 | 2021-12-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | Conformational adaptability determining antibody recognition to distomer: structure analysis of enantioselective antibody against chiral drug gatifloxacin Rsc Adv, 11, 2021
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