2Q5A
| human Pin1 bound to L-PEPTIDE | 分子名称: | 3,6,9,12,15,18-HEXAOXAICOSANE, Five residue peptide, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | 著者 | Noel, J.P, Zhang, Y. | 登録日 | 2007-05-31 | 公開日 | 2007-06-26 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural basis for high-affinity peptide inhibition of human Pin1. Acs Chem.Biol., 2, 2007
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6P79
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6O5W
| Crystal structure of MORC3 CW domain fused with viral influenza A NS1 peptide | 分子名称: | NS1-linked peptide,MORC family CW-type zinc finger protein 3, ZINC ION | 著者 | Ahn, J, Zhang, Y, Vann, K.R, Kutateleadze, T. | 登録日 | 2019-03-04 | 公開日 | 2019-05-08 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.412 Å) | 主引用文献 | MORC3 Is a Target of the Influenza A Viral Protein NS1. Structure, 27, 2019
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3OG7
| B-Raf Kinase V600E oncogenic mutant in complex with PLX4032 | 分子名称: | AKAP9-BRAF fusion protein, N-(3-{[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide | 著者 | Zhang, Y, Zhang, K.Y, Zhang, C. | 登録日 | 2010-08-16 | 公開日 | 2010-09-22 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature, 467, 2010
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3PCU
| Crystal structure of human retinoic X receptor alpha ligand-binding domain complexed with LX0278 and SRC1 peptide | 分子名称: | 2-[(2S)-6-(2-methylbut-3-en-2-yl)-7-oxo-2,3-dihydro-7H-furo[3,2-g]chromen-2-yl]propan-2-yl acetate, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha | 著者 | Zhang, H, Zhang, Y, Shen, H, Chen, J, Li, C, Chen, L, Hu, L, Jiang, H, Shen, X. | 登録日 | 2010-10-22 | 公開日 | 2011-11-16 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | (+)-Rutamarin as a Dual Inducer of Both GLUT4 Translocation and Expression Efficiently Ameliorates Glucose Homeostasis in Insulin-Resistant Mice. Plos One, 7, 2012
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4JND
| Structure of a C.elegans sex determining protein | 分子名称: | Ca(2+)/calmodulin-dependent protein kinase phosphatase, MAGNESIUM ION | 著者 | Feng, Y, Zhang, Y, Ge, J, Yang, M. | 登録日 | 2013-03-15 | 公開日 | 2013-06-19 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.652 Å) | 主引用文献 | Structural insight into Caenorhabditis elegans sex-determining protein FEM-2. J.Biol.Chem., 288, 2013
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4K7F
| Newly identified epitope V60 from HBV core protein complexed with HLA-A*0201 | 分子名称: | Beta-2-microglobulin, Core protein, HLA class I histocompatibility antigen, ... | 著者 | Meng, S.D, Zhang, Y, Wu, Y, Qi, J.X. | 登録日 | 2013-04-17 | 公開日 | 2013-06-05 | 最終更新日 | 2022-08-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The L60V variation in hepatitis B virus core protein elicits new epitope-specific cytotoxic T lymphocytes and enhances viral replication. J.Virol., 87, 2013
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5HMC
| Crystal structure of S. sahachiroi AziG complexed with 5-methyl naphthoic acid | 分子名称: | 5-methylnaphthalene-1-carboxylic acid, Azi13, SULFATE ION | 著者 | Zhang, Y, Erb, M.S, Ealick, S.E. | 登録日 | 2016-01-15 | 公開日 | 2016-02-03 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Polyketide Ring Expansion Mediated by a Thioesterase, Chain Elongation and Cyclization Domain, in Azinomycin Biosynthesis: Characterization of AziB and AziG. Biochemistry, 55, 2016
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1AOG
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1R0V
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1R11
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5Y4O
| Cryo-EM structure of MscS channel, YnaI | 分子名称: | Low conductance mechanosensitive channel YnaI | 著者 | Zhang, Y, Yu, J. | 登録日 | 2017-08-04 | 公開日 | 2019-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | A binding-block ion selective mechanism revealed by a Na/K selective channel. Protein Cell, 9, 2018
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4F6V
| Crystal structure of dehydrosqualene synthase (crtm) from s. aureus complexed with bph-1034, mg2+ and fmp. | 分子名称: | (2E,6Z)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl dihydrogen phosphate, 2,4-dioxo-4-{[3-(3-phenoxyphenyl)propyl]amino}butanoic acid, Dehydrosqualene synthase, ... | 著者 | Lin, F.-Y, Zhang, Y, Liu, Y.-L, Oldfield, E. | 登録日 | 2012-05-15 | 公開日 | 2012-06-13 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis. ACS Med Chem Lett, 3, 2012
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4F6X
| Crystal structure of dehydrosqualene synthase (crtm) from s. aureus complexed with bph-1112 | 分子名称: | 1-[3-(hexyloxy)benzyl]-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid, D(-)-TARTARIC ACID, Dehydrosqualene synthase, ... | 著者 | Lin, F.-Y, Zhang, Y, Liu, Y.-L, Oldfield, E. | 登録日 | 2012-05-15 | 公開日 | 2012-06-20 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis. ACS Med Chem Lett, 3, 2012
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3LZD
| Crystal structure of Dph2 from Pyrococcus horikoshii with 4Fe-4S cluster | 分子名称: | Dph2, IRON/SULFUR CLUSTER, SULFATE ION | 著者 | Torelli, A.T, Zhang, Y, Zhu, X, Lee, M, Dzikovski, B, Koralewski, R.M, Wang, E, Freed, J, Krebs, C, Lin, H, Ealick, S.E. | 登録日 | 2010-03-01 | 公開日 | 2010-07-14 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme. Nature, 465, 2010
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3CIV
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7KHK
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7KHJ
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7KHG
| Crystal structure of KIT kinase domain with a small molecule inhibitor, PLX3397 | 分子名称: | 5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-{[6-(trifluoromethyl)pyridin-3-yl]methyl}pyridin-2-amine, Mast/stem cell growth factor receptor Kit | 著者 | Zhang, Y. | 登録日 | 2020-10-21 | 公開日 | 2021-07-07 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Association of Combination of Conformation-Specific KIT Inhibitors With Clinical Benefit in Patients With Refractory Gastrointestinal Stromal Tumors: A Phase 1b/2a Nonrandomized Clinical Trial. Jama Oncol, 7, 2021
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6N33
| Crystal structure of fms kinase domain with a small molecular inhibitor, PLX5622 | 分子名称: | 6-fluoro-N-[(5-fluoro-2-methoxypyridin-3-yl)methyl]-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]pyridin-2-amine, Macrophage colony-stimulating factor 1 receptor | 著者 | Zhang, Y. | 登録日 | 2018-11-14 | 公開日 | 2019-09-18 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model. Nat Commun, 10, 2019
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7Q83
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4MQ9
| Crystal structure of Thermus thermophilus RNA polymerase holoenzyme in complex with GE23077 | 分子名称: | (2Z)-2-methylbut-2-enoic acid, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Ho, M.X, Arnold, E, Ebright, R.H, Zhang, Y, Tuske, S. | 登録日 | 2013-09-16 | 公開日 | 2014-05-07 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | 主引用文献 | GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3, 2014
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6C00
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6WXK
| PHF23 PHD Domain Apo | 分子名称: | PHD finger protein 23, ZINC ION | 著者 | Vann, K.R, Zhang, J, Zhang, Y, Kutateladze, T. | 登録日 | 2020-05-11 | 公開日 | 2020-07-15 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion. Nat Commun, 11, 2020
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7XED
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