7KHG

Crystal structure of KIT kinase domain with a small molecule inhibitor, PLX3397

Summary for 7KHG

• Entry DOI: 10.2210/pdb7khg/pdb
• Descriptor: Mast/stem cell growth factor receptor Kit, 5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-{[6-(trifluoromethyl)pyridin-3-yl]methyl}pyridin-2-amine (3 entities in total)
• Functional Keywords: transferase, tyrosine-protein kinase, atp-binding, kinase-kinase inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 38459.92

Authors

Zhang, Y. (deposition date: 2020-10-21, release date: 2021-07-07, Last modification date: 2023-10-18)

• Primary citation: Wagner, A.J.,Severson, P.L.,Shields, A.F.,Patnaik, A.,Chugh, R.,Tinoco, G.,Wu, G.,Nespi, M.,Lin, J.,Zhang, Y.,Ewing, T.,Habets, G.,Burton, E.A.,Matusow, B.,Tsai, J.,Tsang, G.,Shellooe, R.,Carias, H.,Chan, K.,Rezaei, H.,Sanftner, L.,Marimuthu, A.,Spevak, W.,Ibrahim, P.N.,Inokuchi, K.,Alcantar, O.,Michelson, G.,Tsiatis, A.C.,Zhang, C.,Bollag, G.,Trent, J.C.,Tap, W.D.; Association of Combination of Conformation-Specific KIT Inhibitors With Clinical Benefit in Patients With Refractory Gastrointestinal Stromal Tumors: A Phase 1b/2a Nonrandomized Clinical Trial.; Jama Oncol, 7:1343-1350, 2021; PubMed: 34236401; DOI: 10.1001/jamaoncol.2021.2086

Experimental method

X-RAY DIFFRACTION (2.15 Å)