7L97
| Crystal structure of STAMBPL1 in complex with an engineered binder | 分子名称: | 1,2-ETHANEDIOL, AMSH-like protease, SULFATE ION, ... | 著者 | Guo, Y, Dong, A, Hou, F, Li, Y, Zhang, W, Arrowsmith, C.H, Edwards, A.M, Tong, Y, Structural Genomics Consortium (SGC) | 登録日 | 2021-01-02 | 公開日 | 2021-08-25 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Structural and functional characterization of ubiquitin variant inhibitors for the JAMM-family deubiquitinases STAMBP and STAMBPL1. J.Biol.Chem., 297, 2021
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7LMT
| Histone-lysine N-methyltransferase NSD2-PWWP1 with compound MRT10241866a | 分子名称: | Histone-lysine N-methyltransferase NSD2, UNKNOWN ATOM OR ION, ~{N}-cyclopropyl-3-oxidanylidene-~{N}-(thiophen-2-ylmethyl)-4~{H}-1,4-benzoxazine-7-carboxamide | 著者 | Lei, M, Freitas, R.F, Dong, A, Schapira, M, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2021-02-05 | 公開日 | 2021-03-10 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | 主引用文献 | Histone-lysine N-methyltransferase NSD2-PWWP1 with compound MRT10241866a To Be Published
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7MWK
| Crystal structure of MBD2 with DNA | 分子名称: | DNA (5'-D(*GP*CP*CP*AP*AP*(MC)P*GP*TP*TP*GP*GP*C)-3'), Methyl-CpG-binding domain protein 2, UNKNOWN ATOM OR ION | 著者 | Liu, K, Dong, A, Edwards, A.M, Arrowsmith, C.H, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2021-05-17 | 公開日 | 2021-07-07 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.453 Å) | 主引用文献 | Crystal structure of MBD2 with DNA To Be Published
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7MWM
| Crystal structure of MBD2 with DNA | 分子名称: | DNA (5'-D(*GP*CP*CP*AP*A)-R(P*(5MC))-D(P*GP*TP*TP*GP*GP*C)-3'), Methyl-CpG-binding domain protein 2, UNKNOWN ATOM OR ION | 著者 | Liu, K, Dong, A, Edwards, A.M, Arrowsmith, C.H, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2021-05-17 | 公開日 | 2021-07-07 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.601 Å) | 主引用文献 | Crystal structure of MBD2 with DNA To Be Published
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7MWL
| The TAM domain of BAZ2A in complex with a 12mer mCG DNA | 分子名称: | Bromodomain adjacent to zinc finger domain protein 2A, DNA (5'-D(*GP*CP*CP*AP*AP*(5CM)P*GP*TP*TP*GP*GP*C)-3'), GLYCEROL | 著者 | Liu, K, Dong, A, Li, Y, Loppnau, P, Edwards, A.M, Arrowsmith, C.H, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2021-05-17 | 公開日 | 2021-07-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | The TAM domain of BAZ2A in complex with a 12mer mCG DNA To Be Published
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7MWI
| Crystal structure of human BAZ2A | 分子名称: | Bromodomain adjacent to zinc finger domain protein 2A, UNKNOWN ATOM OR ION | 著者 | Liu, K, Dong, A, Li, Y, Loppnau, P, Edwards, A.M, Arrowsmith, C.H, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2021-05-17 | 公開日 | 2021-12-29 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural basis of the TAM domain of BAZ2A in binding to DNA or RNA independent of methylation status. J.Biol.Chem., 297, 2021
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3RQR
| Crystal structure of the RYR domain of the rabbit ryanodine receptor | 分子名称: | (UNK)(UNK)(UNK)(UNK), Ryanodine receptor 1 | 著者 | Nair, U.B, Li, W, Dong, A, Walker, J.R, Gramolini, A, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | 登録日 | 2011-04-28 | 公開日 | 2011-06-22 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | 主引用文献 | Structural determination of the phosphorylation domain of the ryanodine receptor. Febs J., 279, 2012
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6BPI
| Crystal structure of SETDB1 Tudor domain with aryl triazole fragment peptide conjugates | 分子名称: | 1,2-ETHANEDIOL, Histone-lysine N-methyltransferase SETDB1, MLY-SER-THR-E2G, ... | 著者 | MADER, P, Mendoza-Sanchez, R, DONG, A, DOBROVETSKY, E, IQBAL, A, CORLESS, V, TEMPEL, W, LIEW, S.K, SMIL, D, DELA SENA, C.C, KENNEDY, S, DIAZ, D.B, SCHAPIRA, M, VEDADI, M, BROWN, P.J, Santhakumar, V, FRYE, S, Bountra, C, Edwards, A.M, YUDIN, A.K, Arrowsmith, C.H, Structural Genomics Consortium (SGC) | 登録日 | 2017-11-23 | 公開日 | 2017-12-27 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Crystal structure of SETDB1 Tudor domain with aryl triazole fragment peptide conjugates to be published
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4HSG
| Crystal structure of human PRMT3 in complex with an allosteric inhibitor (PRMT3- KTD) | 分子名称: | 1-(1,2,3-benzothiadiazol-6-yl)-3-(2-oxo-2-phenylethyl)urea, PRMT3 protein, UNKNOWN ATOM OR ION | 著者 | Dobrovetsky, E, Dong, A, Liu, F, Li, F, Tempel, W, Siarheyeva, A, Hajian, T, Smil, D, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Schapira, M, Jin, J, Vedadi, M, Structural Genomics Consortium (SGC) | 登録日 | 2012-10-30 | 公開日 | 2012-12-05 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors. J. Med. Chem., 56, 2013
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3R1W
| Crystal structure of a carbonic anhydrase from a crude oil degrading psychrophilic library | 分子名称: | carbonic anhydrase | 著者 | Petit, P, Xu, X, Cui, H, Brown, G, Dong, A, Savchenko, A, Yakunin, A.F. | 登録日 | 2011-03-11 | 公開日 | 2011-03-23 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Crystal structure of a carbonic anhydrase from a crude oil degrading psychrophilic library To be Published
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3SM9
| Crystal Structure of Metabotropic glutamate receptor 3 precursor in presence of LY341495 antagonist | 分子名称: | 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine, CHLORIDE ION, Metabotropic glutamate receptor 3, ... | 著者 | Wernimont, A.K, Dong, A, Seitova, A, Crombet, L, Khutoreskaya, G, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Weigelt, J, Cossar, D, Dobrovetsky, E, Structural Genomics Consortium (SGC) | 登録日 | 2011-06-27 | 公開日 | 2011-07-27 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Crystal Structure of Metabotropic glutamate receptor 3 precursor in presence of LY341495 antagonist TO BE PUBLISHED
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3S8I
| The retroviral-like protease (RVP) domain of human DDI1 | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, PHOSPHATE ION, ... | 著者 | Walker, J.R, Asinas, A, Dong, A, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | 登録日 | 2011-05-28 | 公開日 | 2011-07-06 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Retropepsin-Like Domain of Human DDI1 To be Published
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8SIO
| Crystal structure of PRMT3 with YD1-66 | 分子名称: | 5'-S-{3-[N'-(4'-chloro[1,1'-biphenyl]-3-yl)carbamimidamido]propyl}-5'-thioadenosine, Protein arginine N-methyltransferase 3 | 著者 | Song, X, Dong, A, Arrowsmith, C.H, Edwards, A.M, Deng, Y, Huang, R, Min, J. | 登録日 | 2023-04-16 | 公開日 | 2024-04-17 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of PRMT3 with YD1-66 To be published
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8SHB
| Crystal Structure of PRMT3 with Compound YD1-208 | 分子名称: | 5'-S-[3-(N'-phenylcarbamimidamido)propyl]-5'-thioadenosine, Protein arginine N-methyltransferase 3 | 著者 | Song, X, Dong, A, Deng, Y, Huang, R, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2023-04-13 | 公開日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Crystal Structure of PRMT3 with Compound YD1-208 To be published
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5TF2
| CRYSTAL STRUCTURE OF THE WD40 DOMAIN OF THE HUMAN PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN | 分子名称: | Prolactin regulatory element-binding protein, UNKNOWN ATOM OR ION | 著者 | Walker, J.R, Zhang, Q, Dong, A, Wernimont, A, Li, Y, He, H, Tempel, W, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Chen, Z, Tong, Y, Structural Genomics Consortium (SGC) | 登録日 | 2016-09-23 | 公開日 | 2016-11-23 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | CRYSTAL STRUCTURE OF THE WD40 DOMAIN OF THE HUMAN PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN (CASP target) To be published
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8SIG
| Crystal Structure of PRMT4 with Compound YD1-288 | 分子名称: | 5'-{(3-aminopropyl)[2-(benzylcarbamamido)ethyl]amino}-5'-deoxyadenosine, Histone-arginine methyltransferase CARM1, SODIUM ION, ... | 著者 | Song, X, Dong, A, Deng, Y, Huang, R, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2023-04-16 | 公開日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Crystal Structure of PRMT4 with Compound YD1-288 To be published
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8SHR
| Crystal Structure of PRMT3 with Compound YD1-214 | 分子名称: | 5'-S-[2-(phenylcarbamamido)ethyl]-5'-thioadenosine, Protein arginine N-methyltransferase 3 | 著者 | Song, X, Dong, A, Deng, Y, Huang, R, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2023-04-14 | 公開日 | 2024-04-17 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Crystal Structure of PRMT3 with Compound YD1-214 To be published
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8SIH
| Crystal Structure of PRMT4 with Compound YD1-289 | 分子名称: | 5'-{[2-(benzylcarbamamido)ethyl][3-(N'-cyclopentylcarbamimidamido)propyl]amino}-5'-deoxyadenosine, CALCIUM ION, Histone-arginine methyltransferase CARM1 | 著者 | Song, X, Dong, A, Deng, Y, Huang, R, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2023-04-16 | 公開日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Crystal Structure of PRMT4 with Compound YD1-289 To be published
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8SWJ
| Co-crystal structure of 53BP1 tandem Tudor domains in complex with UNC8531 | 分子名称: | (3S)-N-(4'-carbamoyl[1,1'-biphenyl]-3-yl)-1-[4-(4-methylpiperazin-1-yl)pyridine-2-carbonyl]piperidine-3-carboxamide, TP53-binding protein 1, UNKNOWN ATOM OR ION | 著者 | Zeng, H, Dong, A, Shell, D.J, Foley, C, Pearce, K.H, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | 登録日 | 2023-05-18 | 公開日 | 2023-08-02 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Co-crystal structure of 53BP1 tandem Tudor domains in complex with UNC8531 To be published
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8T5I
| Crystal structure of human WDR5 in complex with MR4397 | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, N-[(2S)-1-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-1-oxopentan-2-yl]-3-[(1H-imidazol-1-yl)methyl]benzamide, ... | 著者 | Kimani, S, Dong, A, Li, F, Loppnau, P, Ackloo, S, Vedadi, M, Brown, P.J, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | 登録日 | 2023-06-13 | 公開日 | 2023-08-09 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal structure of human WDR5 in complex with MR4397 To be published
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4E74
| Crystal structure of the RHO GTPASE BINDING DOMAIN of Plexin A4A | 分子名称: | Plexin-A4, UNKNOWN ATOM OR ION | 著者 | Guan, X, Wang, H, Tempel, W, Dong, A, Tong, Y, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC) | 登録日 | 2012-03-16 | 公開日 | 2012-03-28 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Crystal structure of the RHO GTPASE BINDING DOMAIN of Plexin A4A to be published
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5U9N
| Second Bromodomain of cdg4_1340 from Cryptosporidium parvum, complexed with bromosporine | 分子名称: | Bromo domain containing protein, Bromosporine, SULFATE ION | 著者 | Hou, C.F.D, Lin, Y.H, Loppnau, P, Hutchinson, A, Dong, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Hui, R, Walker, J.R, Structural Genomics Consortium (SGC) | 登録日 | 2016-12-16 | 公開日 | 2017-01-18 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Second Bromodomain of cdg4_1340 from Cryptosporidium parvum, complexed with bromosporine To be published
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4MX2
| Crystal Structure of adenylosuccinate lyase from Leishmania donovani | 分子名称: | ADENOSINE MONOPHOSPHATE, Adenylosuccinate lyase, GLYCEROL, ... | 著者 | Wernimont, A.K, Loppnau, P, Dong, A, Krojer, T, Bradley, A, Bushell, S, von Delft, F, Robinson, D, Gilbert, I, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Hui, R, Mottaghi, K, Structural Genomics Consortium (SGC) | 登録日 | 2013-09-25 | 公開日 | 2014-04-16 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal Structure of adenylosuccinate lyase from Leishmania donovani To be Published
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4NXJ
| Crystal Structure of PF3D7_1475600, a bromodomain from Plasmodium Falciparum | 分子名称: | Bromodomain protein | 著者 | Wernimont, A.K, Loppnau, P, Knapp, S, Fonseca, M, Brennan, P.E, Dong, A, Walker, J.R, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hui, R, Hutchinson, A, Structural Genomics Consortium (SGC) | 登録日 | 2013-12-09 | 公開日 | 2014-03-19 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | 主引用文献 | Crystal Structure of PF3D7_1475600, a bromodomain from Plasmodium Falciparum TO BE PUBLISHED
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3F3Y
| Crystal structure of human cytosolic sulfotransferase SULT2A1 in complex with PAP and lithocholic acid | 分子名称: | (3beta,5beta,14beta,17alpha)-3-hydroxycholan-24-oic acid, ADENOSINE-3'-5'-DIPHOSPHATE, Bile salt sulfotransferase | 著者 | Pan, P.W, Dong, A, Amaya, M, Edwards, A.M. | 登録日 | 2008-10-31 | 公開日 | 2009-09-15 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | rystal structure of human cytosolic sulfotransferase SULT2A1 in complex with PAP and lithocholic acid To be Published
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