9AVA

Co-crystal structure of human TREX1 in complex with an inhibitor

This is a non-PDB format compatible entry.

Summary for 9AVA

• Entry DOI: 10.2210/pdb9ava/pdb
• Descriptor: Three-prime repair exonuclease 1, POTASSIUM ION, (2R)-2-[(5R,6S,8R,9aS)-8-amino-1-oxo-5-(2-phenylethyl)hexahydro-1H-pyrrolo[1,2-a][1,4]diazepin-2(3H)-yl]-N-[(3,4-dichlorophenyl)methyl]-4-methylpentanamide, ... (5 entities in total)
• Functional Keywords: trex1, sgc, transport protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 12
• Total formula weight: 304787.27

Authors

Dehghani-Tafti, S.,Dong, A.,Li, Y.,Xu, J.,Ackloo, S.,Arrowsmith, C.H.,Edwards, A.M.,Halabelian, L.,Structural Genomics Consortium (SGC) (deposition date: 2024-03-01, release date: 2024-05-15)

• Primary citation: Dehghani-Tafti, S.,Dong, A.,Li, Y.,Xu, J.,Ackloo, S.,Arrowsmith, C.H.,Edwards, A.M.,Halabelian, L.,Structural Genomics Consortium (SGC); Co-crystal structure of human TREX1 in complex with an inhibitor; To be published,

Experimental method

X-RAY DIFFRACTION (2.3 Å)