7MS5

Structure of USP5 zinc-finger ubiquitin binding domain co-crystallized with 4-(4-(4-(3,4-difluoro-phenyl)-piperidin-1-ylsulfonyl)-phenyl)-4-oxo-butanoic acid

Summary for 7MS5

Entry DOI	10.2210/pdb7ms5/pdb
Descriptor	Ubiquitin carboxyl-terminal hydrolase 5, ZINC ION, 4-{4-[4-(3,4-difluorophenyl)piperidine-1-sulfonyl]phenyl}-4-oxobutanoic acid, ... (6 entities in total)
Functional Keywords	usp5, ubiquitin, usp, ubiquitin specific protease, structural genomics, structural genomics consortium, sgc, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	28178.28
Authors	Mann, M.K.,Zepeda-Velazquez, C.A.,Alvarez, H.G.,Dong, A.,Kiyota, T.,Aman, A.,Arrowsmith, C.H.,Al-Awar, R.,Harding, R.J.,Schapira, M.,Structural Genomics Consortium (SGC) (deposition date: 2021-05-10, release date: 2021-06-09, Last modification date: 2023-10-18)
Primary citation	Mann, M.K.,Zepeda-Velazquez, C.A.,Gonzalez-Alvarez, H.,Dong, A.,Kiyota, T.,Aman, A.M.,Loppnau, P.,Li, Y.,Wilson, B.,Arrowsmith, C.H.,Al-Awar, R.,Harding, R.J.,Schapira, M. Structure-Activity Relationship of USP5 Inhibitors. J.Med.Chem., 64:15017-15036, 2021 Cited by PubMed: 34648286 DOI: 10.1021/acs.jmedchem.1c00889 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.98 Å)

Structure validation