4HSG

Crystal structure of human PRMT3 in complex with an allosteric inhibitor (PRMT3- KTD)

Summary for 4HSG

• Entry DOI: 10.2210/pdb4hsg/pdb
• Descriptor: PRMT3 protein, 1-(1,2,3-benzothiadiazol-6-yl)-3-(2-oxo-2-phenylethyl)urea, UNKNOWN ATOM OR ION, ... (4 entities in total)
• Functional Keywords: prmt3, allosteric inhibitor, structural genomics, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 38594.26

Authors

Dobrovetsky, E.,Dong, A.,Liu, F.,Li, F.,Tempel, W.,Siarheyeva, A.,Hajian, T.,Smil, D.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Brown, P.J.,Schapira, M.,Jin, J.,Vedadi, M.,Structural Genomics Consortium (SGC) (deposition date: 2012-10-30, release date: 2012-12-05, Last modification date: 2023-09-20)

• Primary citation: Liu, F.,Li, F.,Ma, A.,Dobrovetsky, E.,Dong, A.,Gao, C.,Korboukh, I.,Liu, J.,Smil, D.,Brown, P.J.,Frye, S.V.,Arrowsmith, C.H.,Schapira, M.,Vedadi, M.,Jin, J.; Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors.; J. Med. Chem., 56:2110-2124, 2013; PubMed: 23445220; DOI: 10.1021/jm3018332

Experimental method

X-RAY DIFFRACTION (2.3 Å)