4HSG

Crystal structure of human PRMT3 in complex with an allosteric inhibitor (PRMT3- KTD)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	PRMT3 protein	polymer	340	38281.9	1	UniProt (Q8WUV3) Pfam (PF06325) Pfam (PF22528) UniProt (by SIFTS) (O60678) In PDB	Homo sapiens (human)
2	A	1-(1,2,3-benzothiadiazol-6-yl)-3-(2-oxo-2-phenylethyl)urea	non-polymer		312.3	1	Chemie (KTD)
3	A	UNKNOWN ATOM OR ION	non-polymer			17	Chemie (UNX)
4		water	water		18.0	115	Chemie (HOH)

Sequence modifications

A: 228 - 548 (UniProt: Q8WUV3)

PDB	External Database	Details
Met 209	-	expression tag
Gly 210	-	expression tag
Ser 211	-	expression tag
Ser 212	-	expression tag
His 213	-	expression tag
His 214	-	expression tag
His 215	-	expression tag
His 216	-	expression tag
His 217	-	expression tag
His 218	-	expression tag
Ser 219	-	expression tag
Ser 220	-	expression tag
Gly 221	-	expression tag
Leu 222	-	expression tag
Val 223	-	expression tag
Pro 224	-	expression tag
Arg 225	-	expression tag
Gly 226	-	expression tag
Ser 227	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	38281.9
Non-Polymers*	Number of molecules	18
	Total formula weight	312.3
All*	Total formula weight	38594.3

*Water molecules are not included.