2HQE
| Crystal structure of human P100 Tudor domain: Large fragment | 分子名称: | P100 Co-activator tudor domain | 著者 | Shah, N, Zhao, M, Cheng, C, Xu, H, Yang, J, Silvennoinen, O, Liu, Z.J, Wang, B.C, Southeast Collaboratory for Structural Genomics (SECSG) | 登録日 | 2006-07-18 | 公開日 | 2007-07-03 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structure of a large fragment of the Human P100 Tudor Domain To be Published
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6JLI
| Crystal structure of CTLD7 domain of human PLA2R | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Secretory phospholipase A2 receptor | 著者 | Yu, B, Hu, Z, Kong, D, Cheng, C, He, Y. | 登録日 | 2019-03-06 | 公開日 | 2019-07-17 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.778 Å) | 主引用文献 | Crystal structure of the CTLD7 domain of human M-type phospholipase A2 receptor. J.Struct.Biol., 207, 2019
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5JR8
| Disposal of Iron by a Mutant form of Siderocalin NGAL | 分子名称: | GLYCEROL, Neutrophil gelatinase-associated lipocalin, PHOSPHATE ION | 著者 | Rupert, P.B, Strong, R.K, Barasch, J, Hollman, M, Deng, R, Hod, E.A, Abergel, R, Allred, B, Xu, K, Darrah, S, Tekabe, Y, Perlstein, A, Bruck, E, Stauber, J, Corbin, K, Buchen, C, Slavkovich, V, Graziano, J, Spitalnik, S, Qiu, A. | 登録日 | 2016-05-05 | 公開日 | 2016-09-28 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Disposal of iron by a mutant form of lipocalin 2. Nat Commun, 7, 2016
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7E0W
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7E4U
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7E4V
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7E50
| Crystal structure of human microplasmin in complex with kazal-type inhibitor AaTI | 分子名称: | AAEL006007-PA, GLYCEROL, Plasminogen, ... | 著者 | Varsha, A.W, Jobichen, C, Mok, Y.K. | 登録日 | 2021-02-16 | 公開日 | 2022-02-16 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Crystal structure of Aedes aegypti trypsin inhibitor in complex with mu-plasmin reveals role for scaffold stability in Kazal-type serine protease inhibitor. Protein Sci., 31, 2022
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5E38
| Structural basis of mapping the spontaneous mutations with 5-flourouracil in uracil phosphoribosyltransferase from Mycobacterium tuberculosis | 分子名称: | Uracil phosphoribosyltransferase | 著者 | Ghode, P, Jobichen, C, Ramachandran, S, Bifani, P, Sivaraman, J. | 登録日 | 2015-10-02 | 公開日 | 2015-10-21 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural basis of mapping the spontaneous mutations with 5-flurouracil in uracil phosphoribosyltransferase from Mycobacterium tuberculosis Biochem.Biophys.Res.Commun., 467, 2015
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3ECR
| Structure of human porphobilinogen deaminase | 分子名称: | 3-[5-{[3-(2-carboxyethyl)-4-(carboxymethyl)-5-methyl-1H-pyrrol-2-yl]methyl}-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acid, Porphobilinogen deaminase | 著者 | Song, G, Li, Y, Cheng, C, Zhao, Y, Gao, A, Zhang, R, Joachimiak, A, Shaw, N, Liu, Z.J. | 登録日 | 2008-09-01 | 公開日 | 2008-09-30 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.182 Å) | 主引用文献 | Structural insight into acute intermittent porphyria. Faseb J., 23, 2009
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2O4X
| Crystal structure of human P100 tudor domain | 分子名称: | Staphylococcal nuclease domain-containing protein 1 | 著者 | Shaw, N, Zhao, M, Cheng, C, Xu, H, Yang, J, Silvennoinen, O, Rao, Z, Wang, B.C, Liu, Z.J. | 登録日 | 2006-12-05 | 公開日 | 2007-02-13 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of human P100 tudor domain To be Published
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3HY6
| Structure of human MTHFS with ADP | 分子名称: | 5-formyltetrahydrofolate cyclo-ligase, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Wu, D, Li, Y, Song, G, Cheng, C, Shaw, N, Liu, Z.-J. | 登録日 | 2009-06-22 | 公開日 | 2009-07-14 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural basis for the inhibition of human 5,10-methenyltetrahydrofolate synthetase by N10-substituted folate analogues Cancer Res., 69, 2009
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3HY4
| Structure of human MTHFS with N5-iminium phosphate | 分子名称: | 5-formyltetrahydrofolate cyclo-ligase, MAGNESIUM ION, N-({trans-4-[({(2R,4R,4aS,6S,8aS)-2-amino-4-hydroxy-5-[(phosphonooxy)methyl]decahydropteridin-6-yl}methyl)amino]cyclohexyl}carbonyl)-L-glutamic acid, ... | 著者 | Wu, D, Li, Y, Song, G, Cheng, C, Shaw, N, Liu, Z.-J. | 登録日 | 2009-06-22 | 公開日 | 2009-07-14 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.795 Å) | 主引用文献 | Structural basis for the inhibition of human 5,10-methenyltetrahydrofolate synthetase by N10-substituted folate analogues Cancer Res., 69, 2009
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3HXT
| Structure of human MTHFS | 分子名称: | 5-formyltetrahydrofolate cyclo-ligase, MAGNESIUM ION, NICKEL (II) ION | 著者 | Wu, D, Li, Y, Song, G, Cheng, C, Zhang, R, Joachimiak, A, Shaw, N, Liu, Z.-J. | 登録日 | 2009-06-22 | 公開日 | 2009-07-14 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural basis for the inhibition of human 5,10-methenyltetrahydrofolate synthetase by N10-substituted folate analogues Cancer Res., 69, 2009
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3HY3
| Structure of human MTHFS with 10-formyltetrahydrofolate | 分子名称: | 5-formyltetrahydrofolate cyclo-ligase, MAGNESIUM ION, N-({4-[{[(2R,4S,4aR,6S,8aS)-2-amino-4-hydroxydecahydropteridin-6-yl]methyl}(formyl)amino]phenyl}carbonyl)-D-glutamic acid, ... | 著者 | Wu, D, Li, Y, Song, G, Cheng, C, Shaw, N, Liu, Z.-J. | 登録日 | 2009-06-22 | 公開日 | 2009-07-14 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural basis for the inhibition of human 5,10-methenyltetrahydrofolate synthetase by N10-substituted folate analogues Cancer Res., 69, 2009
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7EQZ
| Crystal structure of Carboxypeptidase B complexed with Potato Carboxypeptidase Inhibitor | 分子名称: | Carboxypeptidase B, GLYCINE, Metallocarboxypeptidase inhibitor, ... | 著者 | Choong, Y.K, Gavor, E, Jobichen, C, Sivaraman, J. | 登録日 | 2021-05-05 | 公開日 | 2021-11-10 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of Aedes aegypti carboxypeptidase B1-inhibitor complex uncover the disparity between mosquito and non-mosquito insect carboxypeptidase inhibition mechanism. Protein Sci., 30, 2021
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3KET
| Crystal structure of a Rex-family transcriptional regulatory protein from Streptococcus agalactiae bound to a palindromic operator | 分子名称: | DNA (5'-D(*AP*AP*TP*TP*GP*TP*GP*AP*AP*AP*T)-3'), DNA (5'-D(P*AP*TP*TP*TP*CP*AP*CP*AP*AP*TP*T)-3'), MAGNESIUM ION, ... | 著者 | Thiyagarajan, S, Logan, D, von Wachenfeldt, C. | 登録日 | 2009-10-26 | 公開日 | 2010-11-10 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | NAD+ pool depletion as a signal for the Rex regulon involved in Streptococcus agalactiae virulence. Plos Pathog., 17, 2021
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3KEO
| Crystal Structure of a Rex-family transcriptional regulatory protein from Streptococcus agalactiae complexed with NAD+ | 分子名称: | CHLORIDE ION, MAGNESIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | 著者 | Thiyagarajan, S, Logan, D, von Wachenfeldt, C. | 登録日 | 2009-10-26 | 公開日 | 2010-11-10 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | NAD+ pool depletion as a signal for the Rex regulon involved in Streptococcus agalactiae virulence. Plos Pathog., 17, 2021
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3KEQ
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8DI5
| Cryo-EM structure of SARS-CoV-2 Beta (B.1.351) spike protein in complex with VH domain F6 (focused refinement of RBD and VH F6) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, VH F6 | 著者 | Zhu, X, Saville, J.W, Mannar, D, Berezuk, A.M, Subramaniam, S. | 登録日 | 2022-06-28 | 公開日 | 2022-08-24 | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | 主引用文献 | Potent and broad neutralization of SARS-CoV-2 variants of concern (VOCs) including omicron sub-lineages BA.1 and BA.2 by biparatopic human VH domains. Iscience, 25, 2022
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4MPB
| 1.7 Angstrom resolution crystal structure of betaine aldehyde dehydrogenase (betB) from Staphylococcus aureus | 分子名称: | Betaine aldehyde dehydrogenase, CHLORIDE ION, MAGNESIUM ION | 著者 | Halavaty, A.S, Shuvalova, L, Minasov, G, Dubrovska, I, Winsor, J, Peterson, S.N, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2013-09-12 | 公開日 | 2013-09-25 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure-based mutational studies of substrate inhibition of betaine aldehyde dehydrogenase BetB from Staphylococcus aureus. Appl.Environ.Microbiol., 80, 2014
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4MPY
| 1.85 Angstrom resolution crystal structure of betaine aldehyde dehydrogenase (betB) from Staphylococcus aureus (IDP00699) in complex with NAD+ | 分子名称: | Betaine aldehyde dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SODIUM ION | 著者 | Halavaty, A.S, Minasov, G, Shuvalova, L, Winsor, J, Peterson, S.N, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2013-09-14 | 公開日 | 2013-10-09 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structure-based mutational studies of substrate inhibition of betaine aldehyde dehydrogenase BetB from Staphylococcus aureus. Appl.Environ.Microbiol., 80, 2014
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5DRT
| Crystal structure of Dot1L in complex with inhibitor CPD2 [2-(2-(5-((2-chlorophenoxy)methyl)-1H-tetrazol-1-yl)acetyl)-N-(4-chlorophenyl)hydrazinecarboxamide] | 分子名称: | 2-({5-[(2-chlorophenoxy)methyl]-1H-tetrazol-1-yl}acetyl)-N-(4-chlorophenyl)hydrazinecarboxamide, Histone-lysine N-methyltransferase, H3 lysine-79 specific, ... | 著者 | Scheufler, C, Gaul, C, Be, C, Moebitz, H. | 登録日 | 2015-09-16 | 公開日 | 2016-06-15 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach. Acs Med.Chem.Lett., 7, 2016
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5DSX
| Crystal structure of Dot1L in complex with inhibitor CPD10 [6'-chloro-1,4-dimethyl-5'-(2-methyl-6-((4-(methylamino)pyrimidin-2-yl)amino)-1H-indol-1-yl)-[3,3'-bipyridin]-2(1H)-one] | 分子名称: | 6'-chloro-1,4-dimethyl-5'-(2-methyl-6-{[4-(methylamino)pyrimidin-2-yl]amino}-1H-indol-1-yl)-3,3'-bipyridin-2(1H)-one, Histone-lysine N-methyltransferase, H3 lysine-79 specific, ... | 著者 | Scheufler, C, Gaul, C, Be, C, Moebitz, H. | 登録日 | 2015-09-17 | 公開日 | 2016-06-15 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach. Acs Med.Chem.Lett., 7, 2016
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5DT2
| Crystal structure of Dot1L in complex with inhibitor CPD11 [N4-methyl-N2-(2-methyl-1-(2-phenoxyphenyl)-1H-indol-6-yl)pyrimidine-2,4-diamine] | 分子名称: | Histone-lysine N-methyltransferase, H3 lysine-79 specific, N~4~-methyl-N~2~-[2-methyl-1-(2-phenoxyphenyl)-1H-indol-6-yl]pyrimidine-2,4-diamine, ... | 著者 | Scheufler, C, Gaul, C, Be, C, Moebitz, H. | 登録日 | 2015-09-17 | 公開日 | 2016-06-15 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach. Acs Med.Chem.Lett., 7, 2016
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5DRY
| Crystal structure of Dot1L in complex with inhibitor CPD3 [N-(1-(2-chlorophenyl)-1H-indol-6-yl)-2-(2-(5-(2-chlorophenyl)-1H-tetrazol-1-yl)acetyl)hydrazinecarboxamide] | 分子名称: | Histone-lysine N-methyltransferase, H3 lysine-79 specific, N-[1-(2-chlorophenyl)-1H-indol-6-yl]-2-{[5-(2-chlorophenyl)-1H-tetrazol-1-yl]acetyl}hydrazinecarboxamide, ... | 著者 | Scheufler, C, Gaul, C, Be, C, Moebitz, H. | 登録日 | 2015-09-16 | 公開日 | 2016-06-15 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach. Acs Med.Chem.Lett., 7, 2016
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