5C9C
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![BU of 5c9c by Molmil](/molmil-images/mine/5c9c) | CRYSTAL STRUCTURE OF BRAF(V600E) IN COMPLEX WITH LY3009120 COMPND | 分子名称: | 1-(3,3-dimethylbutyl)-3-{2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl}urea, CHLORIDE ION, Serine/threonine-protein kinase B-raf | 著者 | Edwards, T, Abendroth, J, Chun, L. | 登録日 | 2015-06-26 | 公開日 | 2015-07-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers. Cancer Cell, 28, 2015
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2K0U
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![BU of 2k0u by Molmil](/molmil-images/mine/2k0u) | High Resolution Solution NMR Structures of Oxaliplatin-DNA Adduct | 分子名称: | CYCLOHEXANE-1(R),2(R)-DIAMINE-PLATINUM(II), DNA (5'-D(*DCP*DCP*DTP*DCP*DTP*DGP*DGP*DTP*DCP*DTP*DCP*DC)-3'), DNA (5'-D(*DGP*DGP*DAP*DGP*DAP*DCP*DCP*DAP*DGP*DAP*DGP*DG)-3') | 著者 | Bhattacharyya, D, King, C.L, Chaney, S.G, Campbell, S.L. | 登録日 | 2008-02-15 | 公開日 | 2009-02-03 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Flanking Bases Influence the Nature of DNA Distortion by Platinum 1,2-Intrastrand (GG) Cross-Links. Plos One, 6, 2011
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2K0V
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![BU of 2k0v by Molmil](/molmil-images/mine/2k0v) | High Resolution Solution NMR Structures of Undamaged DNA Dodecamer Duplex | 分子名称: | DNA (5'-D(*DCP*DCP*DTP*DCP*DTP*DGP*DGP*DTP*DCP*DTP*DCP*DC)-3'), DNA (5'-D(*DGP*DGP*DAP*DGP*DAP*DCP*DCP*DAP*DGP*DAP*DGP*DG)-3') | 著者 | Bhattacharyya, D, King, C.L, Chaney, S.G, Campbell, S.L. | 登録日 | 2008-02-15 | 公開日 | 2009-02-03 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Flanking Bases Influence the Nature of DNA Distortion by Platinum 1,2-Intrastrand (GG) Cross-Links. Plos One, 6, 2011
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7T3D
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![BU of 7t3d by Molmil](/molmil-images/mine/7t3d) | |
1OZ1
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![BU of 1oz1 by Molmil](/molmil-images/mine/1oz1) | P38 MITOGEN-ACTIVATED KINASE IN COMPLEX WITH 4-AZAINDOLE INHIBITOR | 分子名称: | 3-(4-FLUOROPHENYL)-2-PYRIDIN-4-YL-1H-PYRROLO[3,2-B]PYRIDIN-1-OL, Mitogen-activated protein kinase 14 | 著者 | Lovejoy, B, Villasenor, A, Browner, M, Dunten, P. | 登録日 | 2003-04-07 | 公開日 | 2003-09-23 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Design and synthesis of 4-azaindoles as inhibitors of p38 MAP kinase. J.Med.Chem., 46, 2003
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2K0T
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![BU of 2k0t by Molmil](/molmil-images/mine/2k0t) | High Resolution Solution NMR Structures of Oxaliplatin-DNA Adduct | 分子名称: | CYCLOHEXANE-1(R),2(R)-DIAMINE-PLATINUM(II), DNA (5'-D(*DCP*DCP*DTP*DCP*DTP*DGP*DGP*DTP*DCP*DTP*DCP*DC)-3'), DNA (5'-D(*DGP*DGP*DAP*DGP*DAP*DCP*DCP*DAP*DGP*DAP*DGP*DG)-3') | 著者 | Bhattacharyya, D, King, C.L, Chaney, S.G, Campbell, S.L. | 登録日 | 2008-02-14 | 公開日 | 2009-02-03 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Flanking Bases Influence the Nature of DNA Distortion by Platinum 1,2-Intrastrand (GG) Cross-Links. Plos One, 6, 2011
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8TBF
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![BU of 8tbf by Molmil](/molmil-images/mine/8tbf) | Tricomplex of RMC-7977, KRAS WT, and CypA | 分子名称: | (1R,5S,6r)-N-[(1P,7S,9S,13S,20M)-20-{5-(4-cyclopropylpiperazin-1-yl)-2-[(1S)-1-methoxyethyl]pyridin-3-yl}-21-ethyl-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide, 1,2-ETHANEDIOL, GTPase KRas, ... | 著者 | Tomlinson, A.C.A, Chen, A, Knox, J.E, Yano, J.K. | 登録日 | 2023-06-28 | 公開日 | 2024-02-07 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy. Nature, 629, 2024
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6WKP
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![BU of 6wkp by Molmil](/molmil-images/mine/6wkp) | Crystal structure of RNA-binding domain of nucleocapsid phosphoprotein from SARS CoV-2, monoclinic crystal form | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Nucleoprotein, ZINC ION | 著者 | Chang, C, Michalska, K, Jedrzejczak, R, Maltseva, N, Endres, M, Godzik, A, Kim, Y, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2020-04-16 | 公開日 | 2020-04-29 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | 主引用文献 | Epitopes recognition of SARS-CoV-2 nucleocapsid RNA binding domain by human monoclonal antibodies. Iscience, 27, 2024
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5J5D
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![BU of 5j5d by Molmil](/molmil-images/mine/5j5d) | |
5T36
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![BU of 5t36 by Molmil](/molmil-images/mine/5t36) | Crystal structure of mPGES-1 bound to inhibitor | 分子名称: | 4-chloro-2-[({(1S,2S)-2-[(2,2-dimethylpropanoyl)amino]cyclopentyl}methyl)amino]benzoic acid, GLUTATHIONE, Prostaglandin E synthase, ... | 著者 | Luz, J.G, Antonysamy, S, Partridge, K, Fisher, M. | 登録日 | 2016-08-24 | 公開日 | 2017-03-01 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1. Bioorg. Med. Chem. Lett., 27, 2017
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6ZY3
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![BU of 6zy3 by Molmil](/molmil-images/mine/6zy3) | Cryo-EM structure of MlaFEDB in complex with phospholipid | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, ABC transporter maintaining OM lipid asymmetry, cytoplasmic STAS component, ... | 著者 | Dong, C.J, Dong, H.H. | 登録日 | 2020-07-30 | 公開日 | 2020-11-25 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural insights into outer membrane asymmetry maintenance in Gram-negative bacteria by MlaFEDB. Nat.Struct.Mol.Biol., 28, 2021
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6VYO
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![BU of 6vyo by Molmil](/molmil-images/mine/6vyo) | Crystal structure of RNA binding domain of nucleocapsid phosphoprotein from SARS coronavirus 2 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, GLYCEROL, ... | 著者 | Chang, C, Michalska, K, Jedrzejczak, R, Maltseva, N, Endres, M, Godzik, A, Kim, Y, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2020-02-27 | 公開日 | 2020-03-11 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Epitopes recognition of SARS-CoV-2 nucleocapsid RNA binding domain by human monoclonal antibodies. Iscience, 27, 2024
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6ZY2
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![BU of 6zy2 by Molmil](/molmil-images/mine/6zy2) | Cryo-EM structure of apo MlaFEDB | 分子名称: | ABC transporter maintaining OM lipid asymmetry, cytoplasmic STAS component, Toluene tolerance protein Ttg2A, ... | 著者 | Dong, C.J, Dong, H.H. | 登録日 | 2020-07-30 | 公開日 | 2020-11-25 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural insights into outer membrane asymmetry maintenance in Gram-negative bacteria by MlaFEDB. Nat.Struct.Mol.Biol., 28, 2021
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6ZY4
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![BU of 6zy4 by Molmil](/molmil-images/mine/6zy4) | Cryo-EM structure of MlaFEDB in complex with ADP | 分子名称: | ABC transporter maintaining OM lipid asymmetry, cytoplasmic STAS component, ADENOSINE-5'-DIPHOSPHATE, ... | 著者 | Dong, C.J, Dong, H.H. | 登録日 | 2020-07-30 | 公開日 | 2020-11-25 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structural insights into outer membrane asymmetry maintenance in Gram-negative bacteria by MlaFEDB. Nat.Struct.Mol.Biol., 28, 2021
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7XUK
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![BU of 7xuk by Molmil](/molmil-images/mine/7xuk) | |
7XUN
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![BU of 7xun by Molmil](/molmil-images/mine/7xun) | |
5TL9
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![BU of 5tl9 by Molmil](/molmil-images/mine/5tl9) | crystal structure of mPGES-1 bound to inhibitor | 分子名称: | 2-{2-[(1S,2S)-2-{[1-(8-methylquinolin-2-yl)piperidine-4-carbonyl]amino}cyclopentyl]ethyl}benzoic acid, DI(HYDROXYETHYL)ETHER, GLUTATHIONE, ... | 著者 | Luz, J.G, Antonysamy, S, Partridge, K, Fisher, M. | 登録日 | 2016-10-10 | 公開日 | 2017-03-01 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1. Bioorg. Med. Chem. Lett., 27, 2017
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5K0I
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![BU of 5k0i by Molmil](/molmil-images/mine/5k0i) | mpges1 bound to an inhibitor | 分子名称: | 1,5-anhydro-2,3,4-trideoxy-3-{[(4S)-3,3-dimethyl-1-(8-methylquinolin-2-yl)piperidine-4-carbonyl]amino}-D-erythro-hexitol, GLUTATHIONE, Prostaglandin E synthase, ... | 著者 | Luz, J.G, Kuklish, S.L. | 登録日 | 2016-05-17 | 公開日 | 2016-09-14 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Characterization of 3,3-dimethyl substituted N-aryl piperidines as potent microsomal prostaglandin E synthase-1 inhibitors. Bioorg.Med.Chem.Lett., 26, 2016
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5T37
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![BU of 5t37 by Molmil](/molmil-images/mine/5t37) | crystal structure of mPGES-1 bound to inhibitor | 分子名称: | 2-chloro-5-{[(2,2-dimethylpropanoyl)amino]methyl}-N-(1H-imidazol-2-yl)benzamide, GLUTATHIONE, Prostaglandin E synthase, ... | 著者 | Luz, J.G, Antonysamy, S, Partridge, K, Fisher, M. | 登録日 | 2016-08-24 | 公開日 | 2017-03-01 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.761 Å) | 主引用文献 | Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1. Bioorg. Med. Chem. Lett., 27, 2017
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8J1F
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![BU of 8j1f by Molmil](/molmil-images/mine/8j1f) | GSK101 bound state of mTRPV4 | 分子名称: | N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide, Transient receptor potential cation channel subfamily V member 4 | 著者 | Zhen, W.X, Yang, F. | 登録日 | 2023-04-12 | 公開日 | 2023-08-09 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.62 Å) | 主引用文献 | Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel. Cell Discov, 9, 2023
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5BQI
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![BU of 5bqi by Molmil](/molmil-images/mine/5bqi) | Discovery of a Potent and Selective mPGES-1 Inhibitor for the Treatment of Pain | 分子名称: | (2-hydroxyethoxy)acetaldehyde, 2-(difluoromethyl)-5-{[(2-methylpropanoyl)amino]methyl}-N-{5-methyl-4-[4-(trifluoromethyl)phenyl]-1H-imidazol-2-yl}pyridine-3-carboxamide, GLUTATHIONE, ... | 著者 | Fisher, M.J, Schiffler, M.A, Kuklish, S.L, Antonysamy, S, Luz, J.G. | 登録日 | 2015-05-29 | 公開日 | 2016-04-13 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors. J.Med.Chem., 59, 2016
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8J1H
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![BU of 8j1h by Molmil](/molmil-images/mine/8j1h) | Agonist1 and Ruthenium Red bound state of mTRPV4 | 分子名称: | 8-fluoranyl-3-[4-(4-fluoranylphenoxy)phenyl]-2-(4-methylpiperazin-1-yl)quinazolin-4-one, Transient receptor potential cation channel subfamily V member 4 | 著者 | Zhen, W.X, Yang, F. | 登録日 | 2023-04-12 | 公開日 | 2023-08-09 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.88 Å) | 主引用文献 | Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel. Cell Discov, 9, 2023
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8J1D
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![BU of 8j1d by Molmil](/molmil-images/mine/8j1d) | Cryo-EM structure of apo state mTRPV4 | 分子名称: | Transient receptor potential cation channel subfamily V member 4 | 著者 | Zhen, W.X, Yang, F. | 登録日 | 2023-04-12 | 公開日 | 2023-08-09 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.59 Å) | 主引用文献 | Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel. Cell Discov, 9, 2023
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8J1B
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![BU of 8j1b by Molmil](/molmil-images/mine/8j1b) | GSK101 and Ruthenium Red bound state of mTRPV4 | 分子名称: | N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide, Transient receptor potential cation channel subfamily V member 4, ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2) | 著者 | Zhen, W.X, Yang, F. | 登録日 | 2023-04-12 | 公開日 | 2023-08-09 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.72 Å) | 主引用文献 | Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel. Cell Discov, 9, 2023
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8JKM
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![BU of 8jkm by Molmil](/molmil-images/mine/8jkm) | RN-1747 bound state of mTRPV4 | 分子名称: | Transient receptor potential cation channel subfamily V member 4 | 著者 | Zhen, W.X, Yang, F. | 登録日 | 2023-06-01 | 公開日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (3.98 Å) | 主引用文献 | Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel. Cell Discov, 9, 2023
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