5T36

Crystal structure of mPGES-1 bound to inhibitor

Summary for 5T36

Entry DOI	10.2210/pdb5t36/pdb
Descriptor	Prostaglandin E synthase, 4-chloro-2-[({(1S,2S)-2-[(2,2-dimethylpropanoyl)amino]cyclopentyl}methyl)amino]benzoic acid, GLUTATHIONE, ... (6 entities in total)
Functional Keywords	prostaglandin, enzyme, integral membrane protein, alpha helix, membrane protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	18746.70
Authors	Luz, J.G.,Antonysamy, S.,Partridge, K.,Fisher, M. (deposition date: 2016-08-24, release date: 2017-03-01, Last modification date: 2024-03-06)
Primary citation	Partridge, K.M.,Antonysamy, S.,Bhattachar, S.N.,Chandrasekhar, S.,Fisher, M.J.,Fretland, A.,Gooding, K.,Harvey, A.,Hughes, N.E.,Kuklish, S.L.,Luz, J.G.,Manninen, P.R.,McGee, J.E.,Mudra, D.R.,Navarro, A.,Norman, B.H.,Quimby, S.J.,Schiffler, M.A.,Sloan, A.V.,Warshawsky, A.M.,Weller, J.M.,York, J.S.,Yu, X.P. Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1. Bioorg. Med. Chem. Lett., 27:1478-1483, 2017 Cited by PubMed: 28190634 DOI: 10.1016/j.bmcl.2016.11.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation