1GDE
| CRYSTAL STRUCTURE OF PYROCOCCUS PROTEIN A-1 E-FORM | 分子名称: | ASPARTATE AMINOTRANSFERASE, GLUTAMIC ACID, PYRIDOXAL-5'-PHOSPHATE | 著者 | Ura, H, Harata, K, Matsui, I, Kuramitsu, S. | 登録日 | 2000-09-23 | 公開日 | 2001-09-23 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Temperature dependence of the enzyme-substrate recognition mechanism. J.Biochem., 129, 2001
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5VEB
| Crystal structure of a Fab binding to extracellular domain 5 of Cadherin-6 | 分子名称: | 2-acetamido-2-deoxy-alpha-D-galactopyranose, Cadherin-6, anti-CDH6 Fab heavy chain, ... | 著者 | Zhu, X, Bialucha, C.U, London, A, Clark, K, Hu, T. | 登録日 | 2017-04-04 | 公開日 | 2017-06-07 | 最終更新日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | 主引用文献 | Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers. Cancer Discov, 7, 2017
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1ROM
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2LWI
| Solution structure of H-RasT35S mutant protein in complex with Kobe2601 | 分子名称: | 2-(2,4-dinitrophenyl)-N-(4-fluorophenyl)hydrazinecarbothioamide, GTPase HRas, MAGNESIUM ION, ... | 著者 | Araki, M, Tamura, A, Shima, F, Kataoka, T. | 登録日 | 2012-08-01 | 公開日 | 2013-05-22 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc.Natl.Acad.Sci.USA, 110, 2013
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8SS0
| Human sterol 14 alpha-demethylase (CYP51) in complex with the reaction intermediate 14 alpha-aldehyde dihydrolanosterol | 分子名称: | 3beta-hydroxy-10alpha,13alpha-lanosta-8,24-dien-30-al, Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Hargrove, T.Y, Wawrzak, Z, Guengerich, F.P, Lepesheva, G.I. | 登録日 | 2023-05-08 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Oxygen-18 Labeling Reveals a Mixed Fe-O Mechanism in the Last Step of Cytochrome P450 51 Sterol 14 alpha-Demethylation. Angew.Chem.Int.Ed.Engl., 63, 2024
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1UDM
| Solution structure of Coactosin-like protein (Cofilin family) from Mus Musculus | 分子名称: | Coactosin-like protein | 著者 | Goroncy, A.K, Kigawa, T, Koshiba, S, Kobayashi, N, Tochio, N, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2003-05-01 | 公開日 | 2004-05-18 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR solution structures of actin depolymerizing factor homology domains. Protein Sci., 18, 2009
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2KTD
| Solution structure of mouse lipocalin-type prostaglandin D synthase / substrate analog (U-46619) complex | 分子名称: | (5Z)-7-{(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid, Prostaglandin-H2 D-isomerase | 著者 | Shimamoto, S, Maruo, H, Yoshida, T, Kato, N, Ohkubo, T. | 登録日 | 2010-01-27 | 公開日 | 2011-02-02 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution Structure of Lipocalin-type Prostaglandin D synthase / Substrate analog complex reveals Open-Closed Conformational Change required for Substrate Recognition To be Published
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1WFS
| Solution Structure of Glia Maturation Factor-gamma from Mus Musculus | 分子名称: | Glia maturation factor gamma | 著者 | Goroncy, A.K, Kigawa, T, Koshiba, S, Kobayashi, N, Tochio, N, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2004-05-26 | 公開日 | 2004-11-26 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR solution structures of actin depolymerizing factor homology domains. Protein Sci., 18, 2009
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8KAD
| Crystal structure of an antibody light chain tetramer with 3D domain swapping | 分子名称: | Antibody light chain | 著者 | Sakai, T, Mashima, T, Kobayashi, N, Ogata, H, Uda, T, Hifumi, E, Hirota, S. | 登録日 | 2023-08-02 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural and thermodynamic insights into antibody light chain tetramer formation through 3D domain swapping. Nat Commun, 14, 2023
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8W42
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8W44
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8W46
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8W48
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8W43
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8W45
| X-ray crystal structure of V30M-TTR in complex with pinostilbene | 分子名称: | 3-[(E)-2-(4-hydroxyphenyl)ethenyl]-5-methoxy-phenol, SODIUM ION, Transthyretin | 著者 | Yokoyama, T. | 登録日 | 2023-08-23 | 公開日 | 2023-11-22 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin. J.Med.Chem., 66, 2023
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8W47
| X-ray crystal structure of V30M-TTR in complex with isorhapontigenin | 分子名称: | 5-[(~{E})-2-(3-methoxy-4-oxidanyl-phenyl)ethenyl]benzene-1,3-diol, SODIUM ION, Transthyretin | 著者 | Yokoyama, T. | 登録日 | 2023-08-23 | 公開日 | 2023-11-22 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin. J.Med.Chem., 66, 2023
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2YJ8
| CATHEPSIN L WITH A NITRILE INHIBITOR | 分子名称: | (2S,4R)-4-(2-chlorophenyl)sulfonyl-N-[1-(iminomethyl)cyclopropyl]-1-[1-(4-iodophenyl)cyclopropyl]carbonyl-pyrrolidine-2-carboxamide, CATHEPSIN L1, GLYCEROL | 著者 | Banner, D.W, Benz, J.M, Haap, W. | 登録日 | 2011-05-19 | 公開日 | 2011-11-23 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Halogen Bonding at the Active Sites of Human Cathepsin L and Mek1 Kinase: Efficient Interactions in Different Environments. Chemmedchem, 6, 2011
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6JOD
| Angiotensin II type 2 receptor with ligand | 分子名称: | Angiotensin II, Heavy chain of 4A03Fab, Light chain of 4A03Fab, ... | 著者 | Asada, H, Iwata, S, Hirata, K, Shimamura, T. | 登録日 | 2019-03-20 | 公開日 | 2020-01-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone. Structure, 28, 2020
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2YJB
| CATHEPSIN L WITH A NITRILE INHIBITOR | 分子名称: | (2S,4R)-4-(2-chlorophenyl)sulfonyl-N-[1-(iminomethyl)cyclopropyl]-1-[1-[4-(trifluoromethyl)phenyl]cyclopropyl]carbonyl-pyrrolidine-2-carboxamide, CATHEPSIN L1, GLYCEROL | 著者 | Banner, D.W, Benz, J.M, Haap, W. | 登録日 | 2011-05-19 | 公開日 | 2011-11-23 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Halogen Bonding at the Active Sites of Human Cathepsin L and Mek1 Kinase: Efficient Interactions in Different Environments. Chemmedchem, 6, 2011
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1V6F
| Solution Structure of Glia Maturation Factor-beta from Mus Musculus | 分子名称: | glia maturation factor, beta | 著者 | Goroncy, A.K, Kigawa, T, Koshiba, S, Tomizawa, T, Kobayashi, N, Tochio, N, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2003-11-29 | 公開日 | 2004-05-29 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR solution structures of actin depolymerizing factor homology domains. Protein Sci., 18, 2009
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2YJ9
| CATHEPSIN L WITH A NITRILE INHIBITOR | 分子名称: | (2S,4R)-4-(2-chlorophenyl)sulfonyl-N-[1-(iminomethyl)cyclopropyl]-1-[1-[4-(trifluoromethyl)phenyl]cyclopropyl]carbonyl-pyrrolidine-2-carboxamide, CATHEPSIN L1, GLYCEROL | 著者 | Banner, D.W, Benz, J.M, Haap, W. | 登録日 | 2011-05-19 | 公開日 | 2011-11-23 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Halogen Bonding at the Active Sites of Human Cathepsin L and Mek1 Kinase: Efficient Interactions in Different Environments. Chemmedchem, 6, 2011
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2YJ2
| CATHEPSIN L WITH A NITRILE INHIBITOR | 分子名称: | (2S,4R)-1-[1-(4-BROMOPHENYL)CYCLOPROPYL]CARBONYL-4-(2-CHLOROPHENYL)SULFONYL-N-[1-(IMINOMETHYL)CYCLOPROPYL]PYRROLIDINE-2-CARBOXAMIDE, CATHEPSIN L1, GLYCEROL | 著者 | Banner, D.W, Benz, J.M, Haap, W. | 登録日 | 2011-05-18 | 公開日 | 2011-11-23 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Halogen Bonding at the Active Sites of Human Cathepsin L and Mek1 Kinase: Efficient Interactions in Different Environments. Chemmedchem, 6, 2011
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7KL1
| Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B(S1303D) | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Calcium/calmodulin-dependent protein kinase type II subunit alpha, ... | 著者 | Ozden, C, Stratton, M.M, Garman, S.C. | 登録日 | 2020-10-28 | 公開日 | 2020-12-23 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | CaMKII binds both substrates and activators at the active site. Cell Rep, 40, 2022
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7KL0
| Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B(S1303D) | 分子名称: | 1,2-ETHANEDIOL, Calcium/calmodulin-dependent protein kinase type II subunit alpha, Glutamate receptor ionotropic, ... | 著者 | Ozden, C, Stratton, M.M, Garman, S.C. | 登録日 | 2020-10-28 | 公開日 | 2020-12-23 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | CaMKII binds both substrates and activators at the active site. Cell Rep, 40, 2022
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6AIT
| Crystal structure of E. coli BepA | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Beta-barrel assembly-enhancing protease, ZINC ION | 著者 | Umar, M.S.M, Tanaka, Y, Kamikubo, H, Tsukazaki, T. | 登録日 | 2018-08-24 | 公開日 | 2018-12-26 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.598 Å) | 主引用文献 | Structural Basis for the Function of the beta-Barrel Assembly-Enhancing Protease BepA. J. Mol. Biol., 431, 2019
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