6KK0
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![BU of 6kk0 by Molmil](/molmil-images/mine/6kk0) | Crystal structure of PDE4D catalytic domain complexed with compound 4e | 分子名称: | 7-[8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)-5-oxidanyl-6-oxidanylidene-pyrano[3,2-b]xanthen-9-yl]oxyheptanoic acid, MAGNESIUM ION, ZINC ION, ... | 著者 | Huang, Y.-Y, He, X, Luo, H.-B. | 登録日 | 2019-07-23 | 公開日 | 2020-03-18 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.20008755 Å) | 主引用文献 | Discovery and Optimization of alpha-Mangostin Derivatives as Novel PDE4 Inhibitors for the Treatment of Vascular Dementia. J.Med.Chem., 63, 2020
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7YFM
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![BU of 7yfm by Molmil](/molmil-images/mine/7yfm) | Structure of GluN1b-GluN2D NMDA receptor in complex with agonists glycine and glutamate. | 分子名称: | Glutamate receptor ionotropic, NMDA 2D, Isoform 6 of Glutamate receptor ionotropic, ... | 著者 | Zhang, J.L, Zhu, S.J, Zhang, M. | 登録日 | 2022-07-08 | 公開日 | 2023-03-29 | 最終更新日 | 2023-08-02 | 実験手法 | ELECTRON MICROSCOPY (5.1 Å) | 主引用文献 | Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits. Nat.Struct.Mol.Biol., 30, 2023
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7YFF
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![BU of 7yff by Molmil](/molmil-images/mine/7yff) | Structure of GluN1a-GluN2D NMDA receptor in complex with agonist glycine and competitive antagonist CPP. | 分子名称: | (2R)-4-(3-phosphonopropyl)piperazine-2-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhang, J.L, Zhu, S.J, Zhang, M. | 登録日 | 2022-07-08 | 公開日 | 2023-04-12 | 最終更新日 | 2023-08-02 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits. Nat.Struct.Mol.Biol., 30, 2023
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7YFL
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![BU of 7yfl by Molmil](/molmil-images/mine/7yfl) | Structure of GluN1a-GluN2D NMDA receptor in complex with agonists glycine and glutamate. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ... | 著者 | Zhang, J.L, Zhu, S.J, Zhang, M. | 登録日 | 2022-07-08 | 公開日 | 2023-04-12 | 最終更新日 | 2023-08-02 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits. Nat.Struct.Mol.Biol., 30, 2023
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7YFO
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7YFR
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![BU of 7yfr by Molmil](/molmil-images/mine/7yfr) | Structure of GluN1a E698C-GluN2D NMDA receptor in cystines non-crosslinked state. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ... | 著者 | Zhang, J.L, Zhu, S.J, Zhang, M. | 登録日 | 2022-07-09 | 公開日 | 2023-04-12 | 最終更新日 | 2023-08-02 | 実験手法 | ELECTRON MICROSCOPY (5.1 Å) | 主引用文献 | Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits. Nat.Struct.Mol.Biol., 30, 2023
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4FFV
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![BU of 4ffv by Molmil](/molmil-images/mine/4ffv) | Crystal Structure of Dipeptidyl Peptidase IV (DPP4, DPP-IV, CD26) in Complex with 11A19 Fab | 分子名称: | 11A19 Fab heavy chain, 11A19 Fab light chain, Dipeptidyl peptidase 4 | 著者 | Wang, Z, Sudom, A, Walker, N.P, Min, X. | 登録日 | 2012-06-01 | 公開日 | 2012-12-12 | 最終更新日 | 2021-05-19 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | An Inhibitory Antibody Against DPP IV Improves Glucose Tolerance in vivo - Validation of Large Molecule Approach for DPP IV Inhibition To be published
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7Y86
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![BU of 7y86 by Molmil](/molmil-images/mine/7y86) | CcpS mutant | 分子名称: | UPF0297 protein A7J08_00425 | 著者 | Tang, J.S, Ran, T.T, Wang, W.W, Fan, H.J. | 登録日 | 2022-06-22 | 公開日 | 2023-05-10 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | A link between STK signalling and capsular polysaccharide synthesis in Streptococcus suis. Nat Commun, 14, 2023
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7Y8Z
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![BU of 7y8z by Molmil](/molmil-images/mine/7y8z) | CcpS | 分子名称: | UPF0297 protein A7J08_00425 | 著者 | Tang, J.S, Ran, T.T, Wang, W.W, Fan, H.J. | 登録日 | 2022-06-24 | 公開日 | 2023-05-10 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | A link between STK signalling and capsular polysaccharide synthesis in Streptococcus suis. Nat Commun, 14, 2023
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6D8E
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5DIJ
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5DLK
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![BU of 5dlk by Molmil](/molmil-images/mine/5dlk) | The crystal structure of CT mutant | 分子名称: | 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, TqaA | 著者 | Zhang, J.R, Tang, Y, Zhou, J.H. | 登録日 | 2015-09-06 | 公開日 | 2016-09-07 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural basis of nonribosomal peptide macrocyclization in fungi Nat.Chem.Biol., 12, 2016
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2GFX
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2GFW
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2GFY
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2GFV
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4FBZ
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![BU of 4fbz by Molmil](/molmil-images/mine/4fbz) | Crystal structure of deltarhodopsin from Haloterrigena thermotolerans | 分子名称: | (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene, 2,3-DI-PHYTANYL-GLYCEROL, BACTERIORUBERIN, ... | 著者 | Kouyama, T. | 登録日 | 2012-05-23 | 公開日 | 2013-05-15 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal structure of deltarhodopsin-3 from Haloterrigena thermotolerans Proteins, 81, 2013
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7CRZ
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![BU of 7crz by Molmil](/molmil-images/mine/7crz) | Crystal structure of human glucose transporter GLUT3 bound with C3361 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S,3R,4S,5R,6R)-6-(hydroxymethyl)-4-undec-10-enoxy-oxane-2,3,5-triol, Solute carrier family 2, ... | 著者 | Yuan, Y.Y, Zhang, S, Wang, N, Jiang, X, Yan, N. | 登録日 | 2020-08-14 | 公開日 | 2021-01-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Orthosteric-allosteric dual inhibitors of PfHT1 as selective antimalarial agents. Proc.Natl.Acad.Sci.USA, 118, 2021
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6LMR
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5YZ9
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![BU of 5yz9 by Molmil](/molmil-images/mine/5yz9) | zinc finger domain of METTL3-METTL14 N6-methyladenosine methyltransferase | 分子名称: | N6-adenosine-methyltransferase catalytic subunit, ZINC ION | 著者 | Dong, X, Tang, C, Gong, Z, Yin, P, Huang, J.B. | 登録日 | 2017-12-13 | 公開日 | 2018-03-28 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR, SOLUTION SCATTERING | 主引用文献 | Solution structure of the RNA recognition domain of METTL3-METTL14 N6-methyladenosine methyltransferase. Protein Cell, 10, 2019
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8GXL
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![BU of 8gxl by Molmil](/molmil-images/mine/8gxl) | HUMAN SUGP1 433-577 | 分子名称: | SURP and G-patch domain-containing protein 1 | 著者 | Xu, K, Tong, L. | 登録日 | 2022-09-20 | 公開日 | 2022-12-14 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | DHX15 is involved in SUGP1-mediated RNA missplicing by mutant SF3B1 in cancer. Proc.Natl.Acad.Sci.USA, 119, 2022
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8GXM
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![BU of 8gxm by Molmil](/molmil-images/mine/8gxm) | HUMAN SUGP1 433-586 | 分子名称: | SURP and G-patch domain-containing protein 1 | 著者 | Xu, K, Tong, L. | 登録日 | 2022-09-20 | 公開日 | 2022-12-14 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | DHX15 is involved in SUGP1-mediated RNA missplicing by mutant SF3B1 in cancer. Proc.Natl.Acad.Sci.USA, 119, 2022
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9AX6
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![BU of 9ax6 by Molmil](/molmil-images/mine/9ax6) | Tricomplex of RMC-6236, KRAS G12D, and CypA | 分子名称: | (1R,2S)-N-[(1P,7S,9S,13R,20M)-21-ethyl-20-{2-[(1R)-1-methoxyethyl]-5-(4-methylpiperazin-1-yl)pyridin-3-yl}-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-2-methylcyclopropane-1-carboxamide, GTPase KRas, MAGNESIUM ION, ... | 著者 | Tomlinson, A.C.A, Saldajeno-Concar, M, Knox, J.E, Yano, J.K. | 登録日 | 2024-03-05 | 公開日 | 2024-04-17 | 最終更新日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers. Cancer Discov, 14, 2024
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8FY5
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![BU of 8fy5 by Molmil](/molmil-images/mine/8fy5) | Human TMEM175-LAMP1 full-length complex | 分子名称: | Endosomal/lysosomal potassium channel TMEM175, Lysosome-associated membrane glycoprotein 1 | 著者 | Zhang, J.Y, Zeng, W.Z, Han, Y, Jiang, Y.X. | 登録日 | 2023-01-25 | 公開日 | 2023-06-28 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel. Mol.Cell, 83, 2023
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8FYF
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![BU of 8fyf by Molmil](/molmil-images/mine/8fyf) | Human TMEM175-LAMP1 transmembrane domain only complex | 分子名称: | Endosomal/lysosomal potassium channel TMEM175, Lysosome-associated membrane glycoprotein 1 | 著者 | Zhang, J.Y, Zeng, W.Z, Han, Y, Jiang, Y.X. | 登録日 | 2023-01-26 | 公開日 | 2023-06-28 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel. Mol.Cell, 83, 2023
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