7XWZ
 
 | | Crystal structure of SARS-CoV-2 N-NTD and dsRNA complex | | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, Nucleoprotein, ... | | 著者 | Luan, X.D, Li, X.M, Li, Y.F. | | 登録日 | 2022-05-27 | | 公開日 | 2023-02-08 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Antiviral drug design based on structural insights into the N-terminal domain and C-terminal domain of the SARS-CoV-2 nucleocapsid protein.
Sci Bull (Beijing), 67, 2022
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7VVV
 | | Crystal structure of MmtN | | 分子名称: | PHOSPHATE ION, SAM-dependent methyltransferase | | 著者 | Peng, M, Li, C.Y. | | 登録日 | 2021-11-09 | | 公開日 | 2022-04-20 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Insights into methionine S-methylation in diverse organisms.
Nat Commun, 13, 2022
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7VVX
 | | MmtN-SAH-Met complex | | 分子名称: | METHIONINE, PHOSPHATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ... | | 著者 | Zhang, Y.Z, Peng, M, Li, C.Y. | | 登録日 | 2021-11-09 | | 公開日 | 2022-04-20 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | | 主引用文献 | Insights into methionine S-methylation in diverse organisms.
Nat Commun, 13, 2022
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7VVW
 | | MmtN-SAM complex | | 分子名称: | GLYCEROL, PHOSPHATE ION, S-ADENOSYLMETHIONINE, ... | | 著者 | Zhang, Y.Z, Peng, M, Li, C.Y. | | 登録日 | 2021-11-09 | | 公開日 | 2022-04-20 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | | 主引用文献 | Insights into methionine S-methylation in diverse organisms.
Nat Commun, 13, 2022
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1JZT
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6JK2
 | | Crystal structure of a mini fungal lectin, PhoSL | | 分子名称: | Lectin, SULFATE ION | | 著者 | Lou, Y.C, Chou, C.C, Yeh, H.H, Chien, C.Y, Sushant, S, Chen, C, Hsu, C.H. | | 登録日 | 2019-02-27 | | 公開日 | 2020-03-04 | | 最終更新日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (1.06 Å) | | 主引用文献 | Structural insights into the role of N-terminal integrity in PhoSL for core-fucosylated N-glycan recognition.
Int.J.Biol.Macromol., 255, 2023
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7X83
 | | Cryo-EM structure of the TMEM106B fibril from normal elder | | 分子名称: | Transmembrane protein 106B | | 著者 | Xia, W.C, Zhao, Q.Y, Fan, Y, Sun, Y.P, Tao, Y.Q, Liu, C. | | 登録日 | 2022-03-11 | | 公開日 | 2022-06-15 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Generic amyloid fibrillation of TMEM106B in patient with Parkinson's disease dementia and normal elders.
Cell Res., 32, 2022
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7E9Y
 | | Crystal structure of eLACCO1 | | 分子名称: | (2S)-2-HYDROXYPROPANOIC ACID, CALCIUM ION, Lactate-binding periplasmic protein TTHA0766,Lactate-binding periplasmic protein TTHA0766 | | 著者 | Wen, Y, Campbell, R.E, Lemieux, M.J, Nasu, Y. | | 登録日 | 2021-03-05 | | 公開日 | 2021-12-22 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | A genetically encoded fluorescent biosensor for extracellular L-lactate.
Nat Commun, 12, 2021
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7E4J
 | | X-ray crystal structure of VapB12 antitoxin from mycobacterium tuberculosis in space group P41. | | 分子名称: | Antitoxin, ZINC ION | | 著者 | Pratap, S, Megta, A.K, Talwar, S, Chandresh, S, Pandey, A.K, Krishnan, V. | | 登録日 | 2021-02-13 | | 公開日 | 2022-02-16 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | | 主引用文献 | X-ray crystal structure of VapB12 antitoxin from mycobacterium tuberculosis in space group P41.
To be published
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3L4W
 | | Crystal complex of N-terminal Human Maltase-Glucoamylase with miglitol | | 分子名称: | (2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Sim, L, Rose, D.R. | | 登録日 | 2009-12-21 | | 公開日 | 2010-02-09 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | New glucosidase inhibitors from an ayurvedic herbal treatment for type 2 diabetes: structures and inhibition of human intestinal maltase-glucoamylase with compounds from Salacia reticulata.
Biochemistry, 49, 2010
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7YPG
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3GTU
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7YOJ
 | | Structure of CasPi with guide RNA and target DNA | | 分子名称: | CasPi, DNA (30-MER), DNA (5'-D(P*CP*GP*GP*GP*AP*TP*GP*CP*CP*CP*AP*G)-3'), ... | | 著者 | Li, C.P, Wang, J, Liu, J.J. | | 登録日 | 2022-08-01 | | 公開日 | 2023-02-15 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | | 主引用文献 | The compact Cas pi (Cas12l) 'bracelet' provides a unique structural platform for DNA manipulation.
Cell Res., 33, 2023
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4FPD
 | | Deprotonation of D96 in bacteriorhodopsin opens the proton uptake pathway | | 分子名称: | 1-[2,6,10.14-TETRAMETHYL-HEXADECAN-16-YL]-2-[2,10,14-TRIMETHYLHEXADECAN-16-YL]GLYCEROL, Bacteriorhodopsin, CHLORIDE ION, ... | | 著者 | Wang, T, Sessions, A.O, Lunde, C.S, Rouani, S, Glaeser, R.M, Facciotti, M.T, Duan, Y. | | 登録日 | 2012-06-22 | | 公開日 | 2013-02-27 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Deprotonation of d96 in bacteriorhodopsin opens the proton uptake pathway.
Structure, 21, 2013
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2QRZ
 | | Cdc42 bound to GMP-PCP: Induced Fit by Effector is Required | | 分子名称: | Cell division control protein 42 homolog precursor, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... | | 著者 | Phillips, M.J, Calero, G, Chan, B, Cerione, R.A. | | 登録日 | 2007-07-30 | | 公開日 | 2008-03-18 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Effector Proteins Exert an Important Influence on the Signaling-active State of the Small GTPase Cdc42.
J.Biol.Chem., 283, 2008
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4U1D
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4U1C
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3CLB
 | | Structure of bifunctional TcDHFR-TS in complex with TMQ | | 分子名称: | 1,2-ETHANEDIOL, DHFR-TS, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Schormann, N, Senkovich, O, Chattopadhyay, D. | | 登録日 | 2008-03-18 | | 公開日 | 2009-01-06 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function.
Proteins, 73, 2008
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2RDE
 | | Crystal structure of VCA0042 complexed with c-di-GMP | | 分子名称: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Uncharacterized protein VCA0042 | | 著者 | Benach, J, Swaminathan, S.S, Tamayo, R, Seetharaman, J, Handelman, S, Forouhar, F, Neely, H, Camilli, A, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2007-09-22 | | 公開日 | 2007-10-30 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | The structural basis of cyclic diguanylate signal transduction by PilZ domains.
Embo J., 26, 2007
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4FT4
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7KFY
 | | Structural basis for a germline-biased antibody response to SARS-CoV-2 (RBD:C1A-F10 Fab) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, heavy chain of human antibody C1A-F10 Fab, ... | | 著者 | Pan, J, Abraham, J, Clark, L, Clark, S. | | 登録日 | 2020-10-15 | | 公開日 | 2020-12-02 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.157 Å) | | 主引用文献 | Molecular basis for a germline-biased neutralizing antibody response to SARS-CoV-2.
Biorxiv, 2020
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4OUC
 | | Structure of human haspin in complex with histone H3 substrate | | 分子名称: | (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, 1,2-ETHANEDIOL, Histone H3.2, ... | | 著者 | Chaikuad, A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2014-02-15 | | 公開日 | 2014-04-16 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Modulation of the chromatin phosphoproteome by the haspin protein kinase.
Mol Cell Proteomics, 13, 2014
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5OHI
 | | Crystal structure of autotaxin in complex with BI-2545 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3,6,9,12,15-PENTAOXAHEPTADECANE, CALCIUM ION, ... | | 著者 | Hoerer, S. | | 登録日 | 2017-07-17 | | 公開日 | 2018-01-03 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | | 主引用文献 | Discovery of BI-2545: A Novel Autotaxin Inhibitor That Significantly Reduces LPA Levels in Vivo.
ACS Med Chem Lett, 8, 2017
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5OLB
 | | crystal structure of autotaxin in complex with PF-8380 | | 分子名称: | (3,5-dichlorophenyl)methyl 4-[3-oxo-3-(2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)propyl]piperazine-1-carboxylate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Hoerer, S, Lammens, A. | | 登録日 | 2017-07-27 | | 公開日 | 2018-01-03 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | Discovery of BI-2545: A Novel Autotaxin Inhibitor That Significantly Reduces LPA Levels in Vivo.
ACS Med Chem Lett, 8, 2017
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4FT2
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