6KNW
| THRb mutation with a novel agonist | 分子名称: | 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl)carbonylamino]ethanoic acid, Nuclear receptor coactivator 2, Thyroid hormone receptor beta | 著者 | Yao, B.Q, Li, Y. | 登録日 | 2019-08-07 | 公開日 | 2019-10-23 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | 主引用文献 | Revealing a Mutant-Induced Receptor Allosteric Mechanism for the Thyroid Hormone Resistance. Iscience, 20, 2019
|
|
7XLQ
| Structure of human R-type voltage-gated CaV2.3-alpha2/delta1-beta1 channel complex in the ligand-free (apo) state | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Gao, Y, Qiu, Y, Wei, Y, Dong, Y, Zhang, X.C, Zhao, Y. | 登録日 | 2022-04-22 | 公開日 | 2023-02-08 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Molecular insights into the gating mechanisms of voltage-gated calcium channel Ca V 2.3. Nat Commun, 14, 2023
|
|
6KKE
| THRb mutation with a novel agonist | 分子名称: | 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl)carbonylamino]ethanoic acid, SRC2-3, Thyroid hormone receptor beta | 著者 | Yao, B.Q, Li, Y. | 登録日 | 2019-07-25 | 公開日 | 2019-10-23 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.577 Å) | 主引用文献 | Revealing a Mutant-Induced Receptor Allosteric Mechanism for the Thyroid Hormone Resistance. Iscience, 20, 2019
|
|
6KNV
| THRb mutation with a novel agonist | 分子名称: | 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl)carbonylamino]ethanoic acid, Nuclear receptor coactivator 2, Thyroid hormone receptor beta | 著者 | Yao, B.Q, Li, Y. | 登録日 | 2019-08-07 | 公開日 | 2019-10-23 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Revealing a Mutant-Induced Receptor Allosteric Mechanism for the Thyroid Hormone Resistance. Iscience, 20, 2019
|
|
6KKB
| A novel agonist of THRb | 分子名称: | 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl)carbonylamino]ethanoic acid, SRC2-3, Thyroid hormone receptor beta | 著者 | Yao, B.Q, Li, Y. | 登録日 | 2019-07-24 | 公開日 | 2019-10-23 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Revealing a Mutant-Induced Receptor Allosteric Mechanism for the Thyroid Hormone Resistance. Iscience, 20, 2019
|
|
6KNU
| THRb mutation with a novel agonist | 分子名称: | 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl)carbonylamino]ethanoic acid, Nuclear receptor coactivator 2, Thyroid hormone receptor beta | 著者 | Yao, B.Q, Li, Y. | 登録日 | 2019-08-07 | 公開日 | 2019-10-23 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Revealing a Mutant-Induced Receptor Allosteric Mechanism for the Thyroid Hormone Resistance. Iscience, 20, 2019
|
|
5CSD
| |
6A2F
| |
5E7X
| Ligand binding domain 1 of Penicillium marneffei MP1 protein in complex with palmitic acid | 分子名称: | ACETATE ION, Cell wall antigen, GLYCEROL, ... | 著者 | Lam, W.H, Zhang, H, Hao, Q. | 登録日 | 2015-10-13 | 公開日 | 2016-10-19 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Talaromyces marneffeiMp1 protein, a novel virulence factor, carries two arachidonic acid-binding domains to suppress inflammatory responses in hosts. Infect. Immun., 2019
|
|
3HAC
| The structure of DPP-4 in complex with piperidine fused imidazopyridine 34 | 分子名称: | (7R,8R)-8-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydroimidazo[1,2-a:4,5-c']dipyridin-7-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Scapin, G. | 登録日 | 2009-05-01 | 公開日 | 2009-07-21 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors Bioorg.Med.Chem.Lett., 19, 2009
|
|
8GW1
| A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors | 分子名称: | Helicase, MANGANESE (II) ION, Non-structural protein 7, ... | 著者 | Yan, L, Rao, Z, Lou, Z. | 登録日 | 2022-09-16 | 公開日 | 2023-10-25 | 最終更新日 | 2024-01-24 | 実験手法 | ELECTRON MICROSCOPY (3.31 Å) | 主引用文献 | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
|
|
8GWM
| SARS-CoV-2 E-RTC bound with MMP-nsp9 and GMPPNP | 分子名称: | 2'-deoxy-2'-fluoro-2'-methyluridine 5'-(trihydrogen diphosphate), Helicase, Non-structural protein 7, ... | 著者 | Yan, L.M, Rao, Z.H, Lou, Z.Y. | 登録日 | 2022-09-17 | 公開日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | 主引用文献 | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
|
|
8GWK
| SARS-CoV-2 RNA E-RTC complex with RMP-nsp9 and GMPPNP | 分子名称: | Helicase, MAGNESIUM ION, Non-structural protein 7, ... | 著者 | Yan, L.M, Huang, Y.C, Ge, J, Liu, Z.Y, Gao, Y, Rao, Z.H, Lou, Z.Y. | 登録日 | 2022-09-17 | 公開日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (2.72 Å) | 主引用文献 | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
|
|
4M5E
| Tse3 structure | 分子名称: | CADMIUM ION, CALCIUM ION, GLYCEROL, ... | 著者 | Qian, Y. | 登録日 | 2013-08-08 | 公開日 | 2014-04-23 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Structural insights into the T6SS effector protein Tse3 and the Tse3-Tsi3 complex from Pseudomonas aeruginosa reveal a calcium-dependent membrane-binding mechanism Mol.Microbiol., 92, 2014
|
|
7DK6
| |
7DCC
| |
7DDN
| SARS-Cov2 S protein at open state | 分子名称: | Spike glycoprotein | 著者 | Cong, Y, Liu, C.X. | 登録日 | 2020-10-29 | 公開日 | 2020-11-25 | 最終更新日 | 2021-01-27 | 実験手法 | ELECTRON MICROSCOPY (6.3 Å) | 主引用文献 | Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections. Nat Commun, 12, 2021
|
|
7DD2
| |
7DK4
| |
7DDD
| SARS-Cov2 S protein at close state | 分子名称: | Spike glycoprotein | 著者 | Cong, Y, Liu, C.X. | 登録日 | 2020-10-28 | 公開日 | 2020-11-25 | 最終更新日 | 2021-01-27 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections. Nat Commun, 12, 2021
|
|
7DCX
| |
7DK7
| |
7DD8
| |
7DK5
| |
3HAB
| The structure of DPP4 in complex with piperidine fused benzimidazole 25 | 分子名称: | (2R,3R)-7-(methylsulfonyl)-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Scapin, G. | 登録日 | 2009-05-01 | 公開日 | 2009-07-21 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors Bioorg.Med.Chem.Lett., 19, 2009
|
|