3HAB

The structure of DPP4 in complex with piperidine fused benzimidazole 25

Summary for 3HAB

Entry DOI	10.2210/pdb3hab/pdb
Related	3HAC
Descriptor	Dipeptidyl peptidase 4 soluble form, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	alpha/beta, beta-propeller, dimer, hydrolase, diabetes, aminopeptidase, cell membrane, disulfide bond, glycoprotein, membrane, protease, secreted, serine protease, signal-anchor, transmembrane, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	174471.52
Authors	Scapin, G. (deposition date: 2009-05-01, release date: 2009-07-21, Last modification date: 2023-09-20)
Primary citation	Edmondson, S.D.,Mastracchio, A.,Cox, J.M.,Eiermann, G.J.,He, H.,Lyons, K.A.,Patel, R.A.,Patel, S.B.,Petrov, A.,Scapin, G.,Wu, J.K.,Xu, S.,Zhu, B.,Thornberry, N.A.,Roy, R.S.,Weber, A.E. Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors Bioorg.Med.Chem.Lett., 19:4097-4101, 2009 Cited by PubMed: 19539471 DOI: 10.1016/j.bmcl.2009.06.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation