6MSA
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![BU of 6msa by Molmil](/molmil-images/mine/6msa) | Novel, potent, selective and brain penetrant phosphodiesterase 10A inhibitors | 分子名称: | 7,8-dimethoxy-1-methyl-2H-pyrazolo[3,4-c]cinnoline, MAGNESIUM ION, ZINC ION, ... | 著者 | Jakob, C.G. | 登録日 | 2018-10-16 | 公開日 | 2019-01-09 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Novel, potent, selective, and brain penetrant phosphodiesterase 10A inhibitors. Bioorg. Med. Chem. Lett., 29, 2019
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6NVQ
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8U1D
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![BU of 8u1d by Molmil](/molmil-images/mine/8u1d) | Cryo-EM structure of vaccine-elicited CD4 binding site antibody DH1285 bound to HIV-1 CH505TFchim.6R.SOSIP.664v4.1 Env Local Refinement | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, DH1285 Heavy Chain, DH1285 Light Chain, ... | 著者 | Thakur, B, Stalls, V.D, Acharya, P. | 登録日 | 2023-08-31 | 公開日 | 2024-01-03 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (4.25 Å) | 主引用文献 | Vaccine induction of CD4-mimicking HIV-1 broadly neutralizing antibody precursors in macaques. Cell, 187, 2024
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5KJQ
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![BU of 5kjq by Molmil](/molmil-images/mine/5kjq) | X-ray structure of PcCel45A in complex with cellobiose expressed in Aspergillus nidullans | 分子名称: | Endoglucanase V-like protein, SULFATE ION, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose | 著者 | Godoy, A.S, Ramia, M.P, Camilo, C.M, Polikarpov, I. | 登録日 | 2016-06-20 | 公開日 | 2017-06-21 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.704 Å) | 主引用文献 | Structure, computational and biochemical analysis of PcCel45A endoglucanase from Phanerochaete chrysosporium and catalytic mechanisms of GH45 subfamily C members. Sci Rep, 8, 2018
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1GWS
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3V42
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5U39
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![BU of 5u39 by Molmil](/molmil-images/mine/5u39) | Pseudomonas aeruginosa LpxC in complex with CHIR-090 | 分子名称: | N-{(1S,2R)-2-hydroxy-1-[(hydroxyamino)carbonyl]propyl}-4-{[4-(morpholin-4-ylmethyl)phenyl]ethynyl}benzamide, UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION | 著者 | Sprague, E.R. | 登録日 | 2016-12-01 | 公開日 | 2017-06-07 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Design, Synthesis, and Properties of a Potent Inhibitor of Pseudomonas aeruginosa Deacetylase LpxC. J. Med. Chem., 60, 2017
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5U3B
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![BU of 5u3b by Molmil](/molmil-images/mine/5u3b) | Pseudomonas aeruginosa LpxC in complex with NVS-LPXC-01 | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, N-[(2S)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-4-[(but-2-yn-1-yl)oxy]benzamide, UDP-3-O-acyl-N-acetylglucosamine deacetylase, ... | 著者 | Sprague, E.R. | 登録日 | 2016-12-01 | 公開日 | 2017-06-07 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Design, Synthesis, and Properties of a Potent Inhibitor of Pseudomonas aeruginosa Deacetylase LpxC. J. Med. Chem., 60, 2017
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6SSW
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6SSU
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4K2G
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![BU of 4k2g by Molmil](/molmil-images/mine/4k2g) | Structure of Pseudomonas aeruginosa PvdQ bound to BRD-A33442372 | 分子名称: | (2S)-(4-fluorophenyl)[6-(trifluoromethyl)pyridin-2-yl]ethanenitrile, 1,2-ETHANEDIOL, Acyl-homoserine lactone acylase PvdQ | 著者 | Drake, E.J, Wurst, J.M, Theriault, J.R, Munoz, B, Gulick, A.M. | 登録日 | 2013-04-09 | 公開日 | 2014-06-18 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Identification of Inhibitors of PvdQ, an Enzyme Involved in the Synthesis of the Siderophore Pyoverdine. Acs Chem.Biol., 9, 2014
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6HA7
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![BU of 6ha7 by Molmil](/molmil-images/mine/6ha7) | Crystal structure of the BiP NBD and MANF complex | 分子名称: | 1,2-ETHANEDIOL, Endoplasmic reticulum chaperone BiP, Mesencephalic astrocyte-derived neurotrophic factor | 著者 | Yan, Y, Ron, D. | 登録日 | 2018-08-07 | 公開日 | 2019-02-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP. Nat Commun, 10, 2019
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6HCN
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![BU of 6hcn by Molmil](/molmil-images/mine/6hcn) | Adenovirus Type 5 Fiber Knob protein at 1.49A resolution | 分子名称: | 1,2-ETHANEDIOL, Fiber protein, MAGNESIUM ION | 著者 | Rizkallah, P.J, Parker, A.L, Baker, A.T. | 登録日 | 2018-08-15 | 公開日 | 2019-02-13 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions. Nat Commun, 10, 2019
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8AM0
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![BU of 8am0 by Molmil](/molmil-images/mine/8am0) | Crystal structure of human T1061E PI3Kalpha in complex with its regulatory subunit and the inhibitor GDC-0077 (Inavolisib) | 分子名称: | (2R)-2-[[2-[(4S)-4-[bis(fluoranyl)methyl]-2-oxidanylidene-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanamide, 1,2-ETHANEDIOL, CHLORIDE ION, ... | 著者 | Goncalves, M, Johnson, J.L, Roewer, K.M. | 登録日 | 2022-08-02 | 公開日 | 2023-12-13 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (2.818 Å) | 主引用文献 | Epinephrine inhibits PI3K alpha via the Hippo kinases. Cell Rep, 42, 2023
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6SSR
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6SSS
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![BU of 6sss by Molmil](/molmil-images/mine/6sss) | Crystal structure of Human Microsomal Glutathione S-Transferase 2 | 分子名称: | 1-(8Z-hexadecenoyl)-sn-glycerol, GLYCEROL, Microsomal glutathione S-transferase 2, ... | 著者 | Thulasingam, M, Nji, E, Haeggstrom, J.Z. | 登録日 | 2019-09-09 | 公開日 | 2021-02-03 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.498 Å) | 主引用文献 | Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis. Nat Commun, 12, 2021
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4JFA
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![BU of 4jfa by Molmil](/molmil-images/mine/4jfa) | Crystal Structure of Plasmodium falciparum Tryptophanyl-tRNA synthetase | 分子名称: | BETA-MERCAPTOETHANOL, POTASSIUM ION, TRYPTOPHAN, ... | 著者 | Khan, S, Garg, A, Manickam, Y, Sharma, A. | 登録日 | 2013-02-28 | 公開日 | 2014-01-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | An appended domain results in an unusual architecture for malaria parasite tryptophanyl-tRNA synthetase Plos One, 8, 2013
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6H9U
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![BU of 6h9u by Molmil](/molmil-images/mine/6h9u) | Crystal structure of the BiP NBD and MANF SAP complex | 分子名称: | D-MALATE, Endoplasmic reticulum chaperone BiP, Mesencephalic astrocyte-derived neurotrophic factor, ... | 著者 | Yan, Y, Ron, D. | 登録日 | 2018-08-06 | 公開日 | 2019-02-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP. Nat Commun, 10, 2019
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6HAB
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![BU of 6hab by Molmil](/molmil-images/mine/6hab) | Crystal structure of BiP V461F (apo) | 分子名称: | DI(HYDROXYETHYL)ETHER, Endoplasmic reticulum chaperone BiP | 著者 | Yan, Y, Ron, D. | 登録日 | 2018-08-07 | 公開日 | 2019-02-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP. Nat Commun, 10, 2019
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6RZO
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6RZN
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6TYL
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![BU of 6tyl by Molmil](/molmil-images/mine/6tyl) | Crystal structure of mammalian Ric-8A:Galpha(i):nanobody complex | 分子名称: | Guanine nucleotide-binding protein G(i) subunit alpha-1, Nanobody A, Nanobody B, ... | 著者 | Mou, T.C, McClelland, L, Yates-Hansen, C, Sprang, S.R. | 登録日 | 2019-08-09 | 公開日 | 2020-03-11 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to G alpha i1. Nat Commun, 11, 2020
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4K2F
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![BU of 4k2f by Molmil](/molmil-images/mine/4k2f) | Structure of Pseudomonas aeruginosa PvdQ bound to BRD-A08522488 | 分子名称: | (2S)-(4-chlorophenyl)(6-chloropyridin-2-yl)ethanenitrile, 1,2-ETHANEDIOL, Acyl-homoserine lactone acylase PvdQ | 著者 | Drake, E.J, Wurst, J.M, Theriault, J.R, Munoz, B, Gulick, A.M. | 登録日 | 2013-04-09 | 公開日 | 2014-06-18 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Identification of Inhibitors of PvdQ, an Enzyme Involved in the Synthesis of the Siderophore Pyoverdine. Acs Chem.Biol., 9, 2014
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5NMK
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![BU of 5nmk by Molmil](/molmil-images/mine/5nmk) | HLA A02 presenting SLFNTIAVL | 分子名称: | 1,2-ETHANEDIOL, Beta-2-microglobulin, GLYCEROL, ... | 著者 | Rizkallah, P.J, Cole, D.K, Fuller, A, Sewell, A.K. | 登録日 | 2017-04-06 | 公開日 | 2017-11-15 | 最終更新日 | 2017-12-20 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | Dual Molecular Mechanisms Govern Escape at Immunodominant HLA A2-Restricted HIV Epitope. Front Immunol, 8, 2017
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5NME
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![BU of 5nme by Molmil](/molmil-images/mine/5nme) | 868 TCR in complex with HLA A02 presenting SLYNTVATL | 分子名称: | 1,2-ETHANEDIOL, Beta-2-microglobulin, GLYCEROL, ... | 著者 | Rizkallah, P.J, Cole, D.K, Fuller, A, Sewell, A.K. | 登録日 | 2017-04-05 | 公開日 | 2017-11-15 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.94 Å) | 主引用文献 | Dual Molecular Mechanisms Govern Escape at Immunodominant HLA A2-Restricted HIV Epitope. Front Immunol, 8, 2017
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