5U3B

Pseudomonas aeruginosa LpxC in complex with NVS-LPXC-01

Summary for 5U3B

• Entry DOI: 10.2210/pdb5u3b/pdb
• Related: 5U39
• Descriptor: UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION, N-[(2S)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-4-[(but-2-yn-1-yl)oxy]benzamide, ... (5 entities in total)
• Functional Keywords: lpxc, hydroxymate, gram negative, hydrolase
• Biological source: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
• Total number of polymer chains: 2
• Total formula weight: 67571.50

Authors

Sprague, E.R. (deposition date: 2016-12-01, release date: 2017-06-07, Last modification date: 2024-03-06)

• Primary citation: Piizzi, G.,Parker, D.T.,Peng, Y.,Dobler, M.,Patnaik, A.,Wattanasin, S.,Liu, E.,Lenoir, F.,Nunez, J.,Kerrigan, J.,McKenney, D.,Osborne, C.,Yu, D.,Lanieri, L.,Bojkovic, J.,Dzink-Fox, J.,Lilly, M.D.,Sprague, E.R.,Lu, Y.,Wang, H.,Ranjitkar, S.,Xie, L.,Wang, B.,Glick, M.,Hamann, L.G.,Tommasi, R.,Yang, X.,Dean, C.R.; Design, Synthesis, and Properties of a Potent Inhibitor of Pseudomonas aeruginosa Deacetylase LpxC.; J. Med. Chem., 60:5002-5014, 2017; PubMed: 28549219; DOI: 10.1021/acs.jmedchem.7b00377

Experimental method

X-RAY DIFFRACTION (2 Å)