6MSA

Novel, potent, selective and brain penetrant phosphodiesterase 10A inhibitors

Summary for 6MSA

Entry DOI	10.2210/pdb6msa/pdb
Descriptor	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	phosphodiesterase, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	77149.93
Authors	Jakob, C.G. (deposition date: 2018-10-16, release date: 2019-01-09, Last modification date: 2024-03-13)
Primary citation	Geneste, H.,Drescher, K.,Jakob, C.,Laplanche, L.,Ochse, M.,Torrent, M. Novel, potent, selective, and brain penetrant phosphodiesterase 10A inhibitors. Bioorg. Med. Chem. Lett., 29:406-412, 2019 Cited by PubMed: 30587449 DOI: 10.1016/j.bmcl.2018.12.029 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.06 Å)

Structure validation