5U39
Pseudomonas aeruginosa LpxC in complex with CHIR-090
Summary for 5U39
Entry DOI | 10.2210/pdb5u39/pdb |
Related | 5U3B |
Descriptor | UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION, N-{(1S,2R)-2-hydroxy-1-[(hydroxyamino)carbonyl]propyl}-4-{[4-(morpholin-4-ylmethyl)phenyl]ethynyl}benzamide, ... (4 entities in total) |
Functional Keywords | lpxc, hydroxymate, gram negative, hydrolase |
Biological source | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
Total number of polymer chains | 1 |
Total formula weight | 33016.68 |
Authors | Sprague, E.R. (deposition date: 2016-12-01, release date: 2017-06-07, Last modification date: 2023-10-04) |
Primary citation | Piizzi, G.,Parker, D.T.,Peng, Y.,Dobler, M.,Patnaik, A.,Wattanasin, S.,Liu, E.,Lenoir, F.,Nunez, J.,Kerrigan, J.,McKenney, D.,Osborne, C.,Yu, D.,Lanieri, L.,Bojkovic, J.,Dzink-Fox, J.,Lilly, M.D.,Sprague, E.R.,Lu, Y.,Wang, H.,Ranjitkar, S.,Xie, L.,Wang, B.,Glick, M.,Hamann, L.G.,Tommasi, R.,Yang, X.,Dean, C.R. Design, Synthesis, and Properties of a Potent Inhibitor of Pseudomonas aeruginosa Deacetylase LpxC. J. Med. Chem., 60:5002-5014, 2017 Cited by PubMed: 28549219DOI: 10.1021/acs.jmedchem.7b00377 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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