4QR5
| Brd4 Bromodomain 1 complex with its novel inhibitors | 分子名称: | Bromodomain-containing protein 4, N-[3-(cyclopentylsulfamoyl)-5-(2-oxo-2,3-dihydro-1,3-thiazol-4-yl)phenyl]cyclopropanecarboxamide | 著者 | Xiong, B, Cao, D.Y, Chen, T.T, Xu, Y.C. | 登録日 | 2014-06-30 | 公開日 | 2015-07-01 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | 主引用文献 | Fragment-based drug discovery of 2-thiazolidinones as BRD4 inhibitors: 2. Structure-based optimization J.Med.Chem., 58, 2015
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4QR3
| Brd4 Bromodomain 1 complex with its novel inhibitors | 分子名称: | Bromodomain-containing protein 4, N-cyclopentyl-3-(2-oxo-2,3-dihydro-1,3-thiazol-4-yl)benzenesulfonamide | 著者 | Xiong, B, Cao, D.Y, Chen, T.T, Xu, Y.C. | 登録日 | 2014-06-30 | 公開日 | 2015-07-01 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.374 Å) | 主引用文献 | Fragment-based drug discovery of 2-thiazolidinones as BRD4 inhibitors: 2. Structure-based optimization J.Med.Chem., 58, 2015
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4QR4
| Brd4 Bromodomain 1 complex with its novel inhibitors | 分子名称: | 2-chloro-N-cyclopentyl-5-(2-oxo-2,3-dihydro-1,3-thiazol-4-yl)benzenesulfonamide, Bromodomain-containing protein 4 | 著者 | Xiong, B, Cao, D.Y, Chen, T.T, Xu, Y.C. | 登録日 | 2014-06-30 | 公開日 | 2015-07-01 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | 主引用文献 | Fragment-based drug discovery of 2-thiazolidinones as BRD4 inhibitors: 2. Structure-based optimization J.Med.Chem., 58, 2015
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6L7E
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6L7I
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6M3H
| Crystal structure of mouse HPF1 | 分子名称: | Histone PARylation factor 1 | 著者 | Sun, F.H, Yun, C.H. | 登録日 | 2020-03-03 | 公開日 | 2021-03-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | 主引用文献 | HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones. Nat Commun, 12, 2021
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6M3G
| Crystal structure of human HPF1 | 分子名称: | Histone PARylation factor 1 | 著者 | Sun, F.H, Yun, C.H. | 登録日 | 2020-03-03 | 公開日 | 2021-03-03 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones. Nat Commun, 12, 2021
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6M3I
| Crystal structure of HPF1/PARP1 complex | 分子名称: | BENZAMIDE, Histone PARylation factor 1, Poly [ADP-ribose] polymerase 1 | 著者 | Sun, F.H, Yun, C.H. | 登録日 | 2020-03-03 | 公開日 | 2021-03-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones. Nat Commun, 12, 2021
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6LUO
| Structure of nurse shark beta-2-microglobulin | 分子名称: | Beta-2-microglobulin | 著者 | Xia, C, Wu, Y. | 登録日 | 2020-01-30 | 公開日 | 2021-04-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.302 Å) | 主引用文献 | The Structure of a Peptide-Loaded Shark MHC Class I Molecule Reveals Features of the Binding between beta 2 -Microglobulin and H Chain Conserved in Evolution. J Immunol., 2021
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6LUP
| Crystal structure of shark MHC CLASS I for 2.3 angstrom | 分子名称: | Beta-2-microglobulin, MHC class I protein, PHE-ALA-ASN-PHE-PHE-ILE-ARG-GLY-LEU | 著者 | Wu, Y, Xia, C. | 登録日 | 2020-01-30 | 公開日 | 2021-04-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.302 Å) | 主引用文献 | The Structure of a Peptide-Loaded Shark MHC Class I Molecule Reveals Features of the Binding between beta 2 -Microglobulin and H Chain Conserved in Evolution. J Immunol., 2021
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6N2G
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7BFZ
| X-ray structure of human prostate-specific membrane antigen(PSMA) in complex with a inhibitor Glu-490 | 分子名称: | (((S)-1-carboxy-5-((E)-2-cyano-3-(5-(1-(3-methoxy-3-oxopropyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophen-2-yl)acrylamido)pentyl)carbamoyl)-L-glutamic acid, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Rakhimbekova, A, Motlova, L, Barinka, C. | 登録日 | 2021-01-05 | 公開日 | 2021-08-18 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | A prostate-specific membrane antigen activated molecular rotor for real-time fluorescence imaging. Nat Commun, 12, 2021
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7CYV
| Crystal structure of FD20, a neutralizing single-chain variable fragment (scFv) in complex with SARS-CoV-2 Spike receptor-binding domain (RBD) | 分子名称: | Spike protein S1, The heavy chain variable region of the scFv FD20,The light chain variable region of the scFv FD20, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Li, Y, Li, T, Lai, Y, Cai, H, Yao, H, Li, D. | 登録日 | 2020-09-04 | 公開日 | 2021-09-15 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.13 Å) | 主引用文献 | Uncovering a conserved vulnerability site in SARS-CoV-2 by a human antibody. Embo Mol Med, 13, 2021
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7E5Y
| Molecular basis for neutralizing antibody 2B11 targeting SARS-CoV-2 RBD | 分子名称: | 2B11 Fab Heavy chain, 2B11 Fab Light chain, Spike protein S1 | 著者 | Wu, H, Yu, F, Wang, Q.S, Zhou, H, Wang, W.W, Zhao, T, Pan, Y.B, Yang, X.M. | 登録日 | 2021-02-21 | 公開日 | 2021-06-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.59 Å) | 主引用文献 | Screening of potent neutralizing antibodies against SARS-CoV-2 using convalescent patients-derived phage-display libraries. Cell Discov, 7, 2021
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7EVS
| Crystal structure of hnRNP LL RRM2 in complex with SETD2 | 分子名称: | Heterogeneous nuclear ribonucleoprotein L-like, SHI domain from Histone-lysine N-methyltransferase SETD2, SULFATE ION | 著者 | Li, F.D, Wang, S.M. | 登録日 | 2021-05-22 | 公開日 | 2021-10-20 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural basis of the interaction between SETD2 methyltransferase and hnRNP L paralogs for governing co-transcriptional splicing. Nat Commun, 12, 2021
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7EVR
| Crystal structure of hnRNP L RRM2 in complex with SETD2 | 分子名称: | Heterogeneous nuclear ribonucleoprotein L, SHI domain from Histone-lysine N-methyltransferase SETD2 | 著者 | Li, F.D, Wang, S.M. | 登録日 | 2021-05-22 | 公開日 | 2021-10-20 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural basis of the interaction between SETD2 methyltransferase and hnRNP L paralogs for governing co-transcriptional splicing. Nat Commun, 12, 2021
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7TYZ
| Cryo-EM structure of SARS-CoV-2 spike in complex with FSR22, an anti-SARS-CoV-2 DARPin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DARPin FSR22, ... | 著者 | Kwon, Y.D, Gorman, J, Kwong, P.D. | 登録日 | 2022-02-15 | 公開日 | 2022-12-07 | 最終更新日 | 2023-03-15 | 実験手法 | ELECTRON MICROSCOPY (3.51 Å) | 主引用文献 | A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins. Nat.Chem.Biol., 19, 2023
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7TZ0
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7YJI
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7XXL
| RBD in complex with Fab14 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab14 heavy chain, Fab14 light chain, ... | 著者 | Lin, J.Q, Tan, Y.J.E, Wu, B, Lescar, J. | 登録日 | 2022-05-30 | 公開日 | 2022-09-14 | 最終更新日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (7.3 Å) | 主引用文献 | Engineering SARS-CoV-2 specific cocktail antibodies into a bispecific format improves neutralizing potency and breadth. Nat Commun, 13, 2022
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7YF5
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7C8V
| Structure of sybody SR4 in complex with the SARS-CoV-2 S Receptor Binding domain (RBD) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Spike protein S1, ... | 著者 | Li, T, Yao, H, Cai, H, Qin, W, Li, D. | 登録日 | 2020-06-03 | 公開日 | 2020-06-24 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection. Nat Commun, 12, 2021
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7C8W
| Structure of sybody MR17 in complex with the SARS-CoV-2 S receptor-binding domain (RBD) | 分子名称: | GLYCEROL, Spike protein S1, Synthetic nanobody MR17, ... | 著者 | Li, T, Cai, H, Yao, H, Qin, W, Li, D. | 登録日 | 2020-06-03 | 公開日 | 2020-06-24 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | 主引用文献 | A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection. Nat Commun, 12, 2021
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7CAN
| Structure of sybody MR17-K99Y in complex with the SARS-CoV-2 S Receptor-binding domain (RBD) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Spike protein S1, ... | 著者 | Li, T, Yao, H, Cai, H, Qin, W, Li, D. | 登録日 | 2020-06-09 | 公開日 | 2020-06-24 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.94 Å) | 主引用文献 | A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection. Nat Commun, 12, 2021
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7C4D
| Marine microorganism esterase | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Putative esterase, ... | 著者 | Zhu, C.H, Wu, Y.K, Isupov, M.N. | 登録日 | 2020-05-16 | 公開日 | 2021-05-26 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Structural Insights into a Novel Esterase from the East Pacific Rise and Its Improved Thermostability by a Semirational Design. J.Agric.Food Chem., 69, 2021
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