1H15
 
 | | X-ray crystal structure of HLA-DRA1*0101/DRB5*0101 complexed with a peptide from Epstein Barr Virus DNA polymerase | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DNA POLYMERASE, ... | | 著者 | Lang, H, Jacobsen, H, Ikemizu, S, Andersson, C, Harlos, K, Madsen, L, Hjorth, P, Sondergaard, L, Svejgaard, A, Wucherpfennig, K, Stuart, D.I, Bell, J.I, Jones, E.Y, Fugger, L. | | 登録日 | 2002-07-02 | | 公開日 | 2002-10-03 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | A Functional and Structural Basis for Tcr Cross-Reactivity in Multiple Sclerosis
Nat.Immunol., 3, 2002
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1GZP
 | | CD1b in complex with GM2 ganglioside | | 分子名称: | B2-MICROGLOBULIN, DOCOSANE, DODECANE, ... | | 著者 | Gadola, S.D, Zaccai, N.R, Harlos, K, Shepherd, D, Ritter, G, Schmidt, R.R, Jones, E.Y, Cerundolo, V. | | 登録日 | 2002-05-24 | | 公開日 | 2002-07-31 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structure of human CD1b with bound ligands at 2.3 A, a maze for alkyl chains.
Nat. Immunol., 3, 2002
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1GZQ
 | | CD1b in complex with Phophatidylinositol | | 分子名称: | 2-[(HYDROXY{[(2R,3R,5S,6R)-2,3,4,5,6-PENTAHYDROXYCYCLOHEXYL]OXY}PHOSPHORYL)OXY]-1-[(PALMITOYLOXY)METHYL]ETHYL HEPTADECANOATE, B2-MICROGLOBULIN, DOCOSANE, ... | | 著者 | Gadola, S.D, Zaccai, N.R, Harlos, K, Shepherd, D, Ritter, G, Schmidt, R.R, Jones, E.Y, Cerundolo, V. | | 登録日 | 2002-05-24 | | 公開日 | 2002-07-31 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Structure of Human Cd1B with Bound Ligands at 2.3 A, a Maze for Alkyl Chains
Nat.Immunol., 3, 2002
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1FNH
 | | CRYSTAL STRUCTURE OF HEPARIN AND INTEGRIN BINDING SEGMENT OF HUMAN FIBRONECTIN | | 分子名称: | PROTEIN (FIBRONECTIN) | | 著者 | Sharma, A, Askari, J, Humphries, M, Jones, E.Y, Stuart, D.I. | | 登録日 | 1999-01-28 | | 公開日 | 1999-03-16 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal structure of a heparin- and integrin-binding segment of human fibronectin.
EMBO J., 18, 1999
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1EVS
 | | CRYSTAL STRUCTURE OF HUMAN ONCOSTATIN M | | 分子名称: | ONCOSTATIN M | | 著者 | Deller, M.C, Hudson, K.R, Ikemizu, S, Bravo, J, Jones, E.Y, Heath, J.K. | | 登録日 | 2000-04-20 | | 公開日 | 2000-09-13 | | 最終更新日 | 2018-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure and functional dissection of the cytostatic cytokine oncostatin M.
Structure Fold.Des., 8, 2000
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1EPF
 | | CRYSTAL STRUCTURE OF THE TWO N-TERMINAL IMMUNOGLOBULIN DOMAINS OF THE NEURAL CELL ADHESION MOLECULE (NCAM) | | 分子名称: | CALCIUM ION, PROTEIN (NEURAL CELL ADHESION MOLECULE) | | 著者 | Kasper, C, Rasmussen, H, Kastrup, J.S, Ikemizu, S, Jones, E.Y, Berezin, V, Bock, E, Larsen, I.K. | | 登録日 | 2000-03-29 | | 公開日 | 2000-10-09 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structural basis of cell-cell adhesion by NCAM.
Nat.Struct.Biol., 7, 2000
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1EMR
 | | CRYSTAL STRUCTURE OF HUMAN LEUKEMIA INHIBITORY FACTOR (LIF) | | 分子名称: | LEUKEMIA INHIBITORY FACTOR | | 著者 | Robinson, R.C, Heath, J.K, Hawkins, N, Samal, B, Jones, E.Y, Betzel, C. | | 登録日 | 2000-03-17 | | 公開日 | 2001-03-21 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Species Variation in Receptor Binding Site Revealed by the Medium Resolution X-ray Structure of Human Leukemia Inhibitory Factor
to be published
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1LKI
 | | THE CRYSTAL STRUCTURE AND BIOLOGICAL FUNCTION OF LEUKEMIA INHIBITORY FACTOR: IMPLICATIONS FOR RECEPTOR BINDING | | 分子名称: | LEUKEMIA INHIBITORY FACTOR | | 著者 | Robinson, R.C, Grey, L.M, Staunton, D, Stuart, D.I, Heath, J.K, Jones, E.Y. | | 登録日 | 1994-12-12 | | 公開日 | 1995-03-31 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The crystal structure and biological function of leukemia inhibitory factor: implications for receptor binding.
Cell(Cambridge,Mass.), 77, 1994
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1LMW
 | | LMW U-PA Structure complexed with EGRCMK (GLU-GLY-ARG Chloromethyl Ketone) | | 分子名称: | L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide, UROKINASE-TYPE PLASMINOGEN ACTIVATOR | | 著者 | Spraggon, G.S, Phillips, C, Nowak, U.K, Ponting, C.P, Saunders, D, Dobson, C.M, Stuart, D.I, Jones, E.Y. | | 登録日 | 1995-07-26 | | 公開日 | 1996-01-29 | | 最終更新日 | 2013-02-27 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | The crystal structure of the catalytic domain of human urokinase-type plasminogen activator.
Structure, 3, 1995
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1LQB
 | | Crystal structure of a hydroxylated HIF-1 alpha peptide bound to the pVHL/elongin-C/elongin-B complex | | 分子名称: | Elongin B, Elongin C, Hypoxia-inducible factor 1 ALPHA, ... | | 著者 | Hon, W.C, Wilson, M.I, Harlos, K, Claridge, T.D, Schofield, C.J, Pugh, C.W, Maxwell, P.H, Ratcliffe, P.J, Stuart, D.I, Jones, E.Y. | | 登録日 | 2002-05-09 | | 公開日 | 2002-07-03 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.
Nature, 417, 2002
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1A1O
 | | MHC CLASS I MOLECULE B*5301 COMPLEXED WITH PEPTIDE LS6 (KPIVQYDNF) FROM THE MALARIA PARASITE P. FALCIPARUM | | 分子名称: | Beta-2-microglobulin, HLA class I histocompatibility antigen, BW-53 B*5301 alpha chain, ... | | 著者 | Smith, K.J, Reid, S.W, Harlos, K, Mcmichael, A.J, Stuart, D.I, Bell, J.I, Jones, E.Y. | | 登録日 | 1997-12-11 | | 公開日 | 1998-04-08 | | 最終更新日 | 2023-08-02 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Bound water structure and polymorphic amino acids act together to allow the binding of different peptides to MHC class I HLA-B53.
Immunity, 4, 1996
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1B6U
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1B8K
 | | Neurotrophin-3 from Human | | 分子名称: | PROTEIN (NEUROTROPHIN-3) | | 著者 | Robinson, R.C, Radziejewski, C, Stuart, D.I, Jones, E.Y, Choe, S. | | 登録日 | 1999-02-01 | | 公開日 | 1999-02-09 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site.
Protein Sci., 8, 1999
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1AKJ
 | | COMPLEX OF THE HUMAN MHC CLASS I GLYCOPROTEIN HLA-A2 AND THE T CELL CORECEPTOR CD8 | | 分子名称: | BETA 2-MICROGLOBULIN, HIV REVERSE TRANSCRIPTASE EPITOPE, MHC CLASS I HISTOCOMPATIBILITY ANTIGEN (HLA-A*0201) (ALPHA CHAIN), ... | | 著者 | Tormo, J, Stuart, D.I, Jones, E.Y. | | 登録日 | 1997-05-21 | | 公開日 | 1997-09-17 | | 最終更新日 | 2023-08-02 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2.
Nature, 387, 1997
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1A1M
 | | MHC CLASS I MOLECULE B*5301 COMPLEXED WITH PEPTIDE TPYDINQML FROM GAG PROTEIN OF HIV2 | | 分子名称: | Beta-2-microglobulin, HLA class I histocompatibility antigen, BW-53 B*5301 alpha chain, ... | | 著者 | Smith, K.J, Reid, S.W, Harlos, K, Mcmichael, A.J, Stuart, D.I, Bell, J.I, Jones, E.Y. | | 登録日 | 1997-12-11 | | 公開日 | 1998-04-08 | | 最終更新日 | 2023-08-02 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Bound water structure and polymorphic amino acids act together to allow the binding of different peptides to MHC class I HLA-B53.
Immunity, 4, 1996
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1BQU
 | | CYTOKYNE-BINDING REGION OF GP130 | | 分子名称: | GLYCEROL, PROTEIN (GP130), SULFATE ION | | 著者 | Bravo, J, Staunton, D, Heath, J.K, Jones, E.Y. | | 登録日 | 1998-08-18 | | 公開日 | 1998-08-26 | | 最終更新日 | 2022-12-21 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of a cytokine-binding region of gp130.
EMBO J., 17, 1998
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1A1N
 | | MHC CLASS I MOLECULE B*3501 COMPLEXED WITH PEPTIDE VPLRPMTY FROM THE NEF PROTEIN (75-82) OF HIV1 | | 分子名称: | Beta-2-microglobulin, HLA class I histocompatibility antigen, BW-53 B*5301 alpha chain, ... | | 著者 | Smith, K.J, Reid, S.W, Stuart, D.I, Mcmichael, A.J, Jones, E.Y, Bell, J.I. | | 登録日 | 1997-12-11 | | 公開日 | 1998-04-08 | | 最終更新日 | 2023-08-02 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | An altered position of the alpha 2 helix of MHC class I is revealed by the crystal structure of HLA-B*3501.
Immunity, 4, 1996
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1BND
 | | STRUCTURE OF THE BRAIN-DERIVED NEUROTROPHIC FACTOR(SLASH)NEUROTROPHIN 3 HETERODIMER | | 分子名称: | BRAIN DERIVED NEUROTROPHIC FACTOR, ISOPROPYL ALCOHOL, NEUROTROPHIN 3 | | 著者 | Robinson, R.C, Radziejewski, C, Stuart, D.I, Jones, E.Y. | | 登録日 | 1994-12-12 | | 公開日 | 1996-04-04 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer.
Biochemistry, 34, 1995
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7B8G
 | | Notum-Fragment 159 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-phenylmethoxyaniline, Palmitoleoyl-protein carboxylesterase NOTUM, ... | | 著者 | Zhao, Y, Jonees, E.Y. | | 登録日 | 2020-12-12 | | 公開日 | 2022-01-12 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | | 主引用文献 | Structural Analysis and Development of Notum Fragment Screening Hits.
Acs Chem Neurosci, 13, 2022
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7B3G
 | | Notum complex with ARUK3003902 | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-((2-chlorophenyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one, ... | | 著者 | Zhao, Y, Jone, E.Y. | | 登録日 | 2020-11-30 | | 公開日 | 2021-12-08 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | | 主引用文献 | Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity.
J.Med.Chem., 65, 2022
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7B84
 | | Notum-Fragment065 | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... | | 著者 | Zhao, Y, Jonees, E.Y. | | 登録日 | 2020-12-12 | | 公開日 | 2022-01-12 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | | 主引用文献 | Structural Analysis and Development of Notum Fragment Screening Hits.
Acs Chem Neurosci, 13, 2022
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7B8C
 | | Notum-Fragment 147 | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-methyl-~{N}-(2-methylpropyl)imidazo[1,2-a]pyridine-3-carboxamide, ... | | 著者 | Zhao, Y, Jonees, E.Y. | | 登録日 | 2020-12-12 | | 公開日 | 2022-01-12 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | | 主引用文献 | Structural Analysis and Development of Notum Fragment Screening Hits.
Acs Chem Neurosci, 13, 2022
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7B8F
 | | Notum-Fragment 154 | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(benzimidazol-1-ylmethyl)benzenecarbonitrile, ... | | 著者 | Zhao, Y, Jonees, E.Y. | | 登録日 | 2020-12-12 | | 公開日 | 2022-01-12 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | | 主引用文献 | Structural Analysis and Development of Notum Fragment Screening Hits.
Acs Chem Neurosci, 13, 2022
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7B87
 | | Notum-Fragment074 | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... | | 著者 | Zhao, Y, Jonees, E.Y. | | 登録日 | 2020-12-12 | | 公開日 | 2022-01-12 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | | 主引用文献 | Structural Analysis and Development of Notum Fragment Screening Hits.
Acs Chem Neurosci, 13, 2022
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7B86
 | | Notum-Fragment067 | | 分子名称: | 1,2-ETHANEDIOL, 2-[4-(1~{H}-pyrazol-3-yl)phenoxy]pyrimidine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhao, Y, Jonees, E.Y. | | 登録日 | 2020-12-12 | | 公開日 | 2022-01-12 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Structural Analysis and Development of Notum Fragment Screening Hits.
Acs Chem Neurosci, 13, 2022
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