1EVS

CRYSTAL STRUCTURE OF HUMAN ONCOSTATIN M

Summary for 1EVS

Entry DOI	10.2210/pdb1evs/pdb
Descriptor	ONCOSTATIN M (2 entities in total)
Functional Keywords	4-helix bundle, gp130 binding cytokine, cytokine
Biological source	Homo sapiens (human)
Cellular location	Secreted: P13725
Total number of polymer chains	1
Total formula weight	21143.25
Authors	Deller, M.C.,Hudson, K.R.,Ikemizu, S.,Bravo, J.,Jones, E.Y.,Heath, J.K. (deposition date: 2000-04-20, release date: 2000-09-13, Last modification date: 2024-10-30)
Primary citation	Deller, M.C.,Hudson, K.R.,Ikemizu, S.,Bravo, J.,Jones, E.Y.,Heath, J.K. Crystal structure and functional dissection of the cytostatic cytokine oncostatin M. Structure Fold.Des., 8:863-874, 2000 Cited by PubMed Abstract: The cytokine oncostatin M (OSM) inhibits growth of certain tumour-derived cells, induces proliferation in other cell types (e.g. haemangioblasts) and is a mediator of inflammatory responses. Its mechanism of action is via specific binding to gp130 and either the leukaemia inhibitory factor receptor (LIFR) or oncostatin M receptor (OSMR) systems at the cell surface to form an active signalling complex. PubMed: 10997905 DOI: 10.1016/S0969-2126(00)00176-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation