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3E8E
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Crystal structures of the kinase domain of PKA in complex with ATP-competitive inhibitors
分子名称: 4-[2-(4-amino-2,5-dihydro-1,2,5-oxadiazol-3-yl)-6-{[(1S)-3-amino-1-phenylpropyl]oxy}-1-ethyl-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol, PKI inhibitor peptide, cAMP-dependent protein kinase catalytic subunit alpha
著者Concha, N.O, Elkins, P.A, Smallwood, A, Ward, P.
登録日2008-08-19
公開日2008-11-18
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Aminofurazans as potent inhibitors of AKT kinase
Bioorg.Med.Chem.Lett., 19, 2009
3PKI
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BU of 3pki by Molmil
Human SIRT6 crystal structure in complex with ADP ribose
分子名称: NAD-dependent deacetylase sirtuin-6, SULFATE ION, UNKNOWN ATOM OR ION, ...
著者Pan, P.W, Dong, A, Qiu, W, Loppnau, P, Wang, J, Ravichandran, M, Bochkarev, A, Bountra, C, Weigelt, J, Arrowsmith, C.H, Min, J, Edwards, A.M, Structural Genomics Consortium (SGC)
登録日2010-11-11
公開日2011-01-26
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Structure and biochemical functions of SIRT6.
J.Biol.Chem., 286, 2011
3E88
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Crystal structures of the kinase domain of AKT2 in complex with ATP-competitive inhibitors
分子名称: 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-6-{[(2R)-2-amino-3-phenylpropyl]oxy}-1-ethyl-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol, Glycogen synthase kinase-3 beta peptide, RAC-beta serine/threonine-protein kinase
著者Concha, N.O, Elkins, P.A, Smallwood, A, Ward, P.
登録日2008-08-19
公開日2008-10-14
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Aminofurazans as potent inhibitors of AKT kinase
Bioorg.Med.Chem.Lett., 19, 2009
3PKJ
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BU of 3pkj by Molmil
Human SIRT6 crystal structure in complex with 2'-N-Acetyl ADP ribose
分子名称: NAD-dependent deacetylase sirtuin-6, SULFATE ION, UNKNOWN ATOM OR ION, ...
著者Pan, P.W, Dong, A, Qiu, W, Loppnau, P, Wang, J, Ravichandran, M, Walker, J.R, Bountra, C, Weigelt, J, Arrowsmith, C.H, Min, J, Edwards, A.M, Structural Genomics Consortium (SGC)
登録日2010-11-11
公開日2011-01-26
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Structure and biochemical functions of SIRT6.
J.Biol.Chem., 286, 2011
3E87
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BU of 3e87 by Molmil
Crystal structures of the kinase domain of AKT2 in complex with ATP-competitive inhibitors
分子名称: Glycogen synthase kinase-3 beta peptide, N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide, RAC-beta serine/threonine-protein kinase
著者Concha, N.O, Elkins, P.A, Smallwood, A, Ward, P.
登録日2008-08-19
公開日2008-10-14
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Aminofurazans as potent inhibitors of AKT kinase
Bioorg.Med.Chem.Lett., 19, 2009
1LMB
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BU of 1lmb by Molmil
REFINED 1.8 ANGSTROM CRYSTAL STRUCTURE OF THE LAMBDA REPRESSOR-OPERATOR COMPLEX
分子名称: DNA (5'-D(*AP*AP*TP*AP*CP*CP*AP*CP*TP*GP*GP*CP*GP*GP*TP*GP*A P*TP*AP*T)-3'), DNA (5'-D(*TP*AP*TP*AP*TP*CP*AP*CP*CP*GP*CP*CP*AP*GP*TP*GP*G P*TP*AP*T)-3'), PROTEIN (LAMBDA REPRESSOR)
著者Beamer, L.J, Pabo, C.O.
登録日1991-11-05
公開日1991-11-05
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Refined 1.8 A crystal structure of the lambda repressor-operator complex.
J.Mol.Biol., 227, 1992
1LRP
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BU of 1lrp by Molmil
COMPARISON OF THE STRUCTURES OF CRO AND LAMBDA REPRESSOR PROTEINS FROM BACTERIOPHAGE LAMBDA
分子名称: LAMBDA REPRESSOR
著者Pabo, C, Lewis, M.
登録日1987-12-04
公開日1989-01-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Comparison of the structures of cro and lambda repressor proteins from bacteriophage lambda.
J.Mol.Biol., 169, 1983
8URU
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BU of 8uru by Molmil
Spo11 core complex with hairpin DNA
分子名称: Antiviral protein SKI8, Hairpin DNA, MAGNESIUM ION, ...
著者Yu, Y, Patel, D.J.
登録日2023-10-26
公開日2024-06-26
最終更新日2024-10-09
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Cryo-EM structures of the Spo11 core complex bound to DNA.
Nat.Struct.Mol.Biol., 2024
8URQ
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Spo11 core complex with gapped DNA
分子名称: Antiviral protein SKI8, MAGNESIUM ION, Meiosis-specific protein SPO11, ...
著者Yu, Y, Patel, D.J.
登録日2023-10-26
公開日2024-06-26
最終更新日2024-10-09
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Cryo-EM structures of the Spo11 core complex bound to DNA.
Nat.Struct.Mol.Biol., 2024
8WCP
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BU of 8wcp by Molmil
Cryo-EM structure of human disease-associated P301L Tau amyloid fibril from mouse brain
分子名称: Island A, Island B, P301L Tau amyloid fibril from rTg4510 mice
著者Liu, K.E, Zhao, W.B, Liu, C.
登録日2023-09-13
公開日2024-06-19
実験手法ELECTRON MICROSCOPY (3.28 Å)
主引用文献Cryo-EM structures reveal variant Tau amyloid fibrils between the rTg4510 mouse model and sporadic human tauopathies.
Cell Discov, 10, 2024
6JQ5
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BU of 6jq5 by Molmil
The structure of Hatchet Ribozyme
分子名称: MAGNESIUM ION, RNA (82-MER)
著者Ren, A, Zheng, L.
登録日2019-03-29
公開日2019-06-12
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.059 Å)
主引用文献Hatchet ribozyme structure and implications for cleavage mechanism.
Proc.Natl.Acad.Sci.USA, 116, 2019
6JG9
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BU of 6jg9 by Molmil
Crystal structure of AimR in complex with arbitrium peptide
分子名称: AimR transcriptional regulator, arbitrium peptide
著者Guan, Z.Y, Pei, K, Zou, T.T.
登録日2019-02-13
公開日2019-07-03
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.998 Å)
主引用文献Structural insights into DNA recognition by AimR of the arbitrium communication system in the SPbeta phage.
Cell Discov, 5, 2019
6JL7
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BU of 6jl7 by Molmil
crystal structure of TBC1D23 N terminal domain
分子名称: TBC1 domain family member 23
著者Sun, Q, Hu, W, Jia, D.
登録日2019-03-04
公開日2020-03-04
最終更新日2021-09-15
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of TBC1D23 N-terminus reveals a novel role for rhodanese domain.
Plos Biol., 18, 2020
6JQ6
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Hatchet Ribozyme Structure soaking with Ir(NH3)6+
分子名称: IRIDIUM HEXAMMINE ION, RNA (81-MER)
著者Ren, A, Zheng, L.
登録日2019-03-29
公開日2019-06-12
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.626 Å)
主引用文献Hatchet ribozyme structure and implications for cleavage mechanism.
Proc.Natl.Acad.Sci.USA, 116, 2019
6JG8
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Crystal structure of AimR in complex with DNA
分子名称: AimR transcriptional regulator, DNA (31-MER)
著者Guan, Z.Y, Pei, K, Zou, T.T.
登録日2019-02-13
公開日2019-07-03
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.097 Å)
主引用文献Structural insights into DNA recognition by AimR of the arbitrium communication system in the SPbeta phage.
Cell Discov, 5, 2019
7F2O
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BU of 7f2o by Molmil
Cryo-EM structure of the type 2 bradykinin receptor in complex with the bradykinin and an Gq protein
分子名称: ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG, B2 bradykinin receptor, G subunit q (Gi1-Gq chimeric), ...
著者Yin, Y, Jiang, Y.
登録日2021-06-11
公開日2021-10-13
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Molecular basis for kinin selectivity and activation of the human bradykinin receptors.
Nat.Struct.Mol.Biol., 28, 2021
6HBT
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The structure of the G. violaceus guanidine II riboswitch P2 stem-loop with arcaine
分子名称: 1-(4-carbamimidamidobutyl)guanidine, RNA (5'-R(*GP*GP*UP*GP*GP*GP*GP*AP*CP*GP*AP*CP*CP*CP*CP*AP*(CBV)P*C)-3'), SULFATE ION
著者Huang, L, Lilley, D.M.J.
登録日2018-08-13
公開日2019-02-20
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献Structure-guided design of a high-affinity ligand for a riboswitch.
Rna, 25, 2019
8VC8
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BU of 8vc8 by Molmil
Crystal structure of heme-loaded design: HEM_3.C9
分子名称: HEM_3.C9, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION
著者Kalvet, I, Bera, A.K, Baker, D.
登録日2023-12-13
公開日2024-03-20
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Generalized biomolecular modeling and design with RoseTTAFold All-Atom.
Science, 384, 2024
6HBX
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BU of 6hbx by Molmil
The structure of the G. violaceus guanidine II riboswitch P2 stem-loop with ethylguanidine
分子名称: N-ETHYLGUANIDINE, RNA (5'-R(*GP*GP*UP*GP*GP*GP*GP*AP*CP*GP*AP*CP*CP*CP*CP*AP*(CBV)P*C)-3'), SODIUM ION, ...
著者Huang, L, Lilley, D.M.J.
登録日2018-08-13
公開日2019-02-20
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Structure-guided design of a high-affinity ligand for a riboswitch.
Rna, 25, 2019
6HC5
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BU of 6hc5 by Molmil
The structure of the G. violaceus guanidine II riboswitch P2 stem-loop with audouine
分子名称: 1-(5-carbamimidamidopentyl)guanidine, RNA (5'-R(*GP*GP*UP*GP*GP*GP*GP*AP*CP*GP*AP*CP*CP*CP*CP*AP*(CBV)P*C)-3'), SODIUM ION, ...
著者Huang, L, Lilley, D.M.J.
登録日2018-08-14
公開日2019-02-20
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.413 Å)
主引用文献Structure-guided design of a high-affinity ligand for a riboswitch.
Rna, 25, 2019
7EIB
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BU of 7eib by Molmil
Cryo-EM structure of the type 1 bradykinin receptor in complex with the des-Arg10-kallidin and an Gq protein
分子名称: B1 bradykinin receptor, G subunit q (Gi1-Gq chimeric), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Yin, Y, Jiang, Y.
登録日2021-03-30
公開日2021-10-13
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Molecular basis for kinin selectivity and activation of the human bradykinin receptors.
Nat.Struct.Mol.Biol., 28, 2021
6JG5
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Crystal structure of AimR
分子名称: AimR transcriptional regulator
著者Guan, Z.Y, Pei, K, Zou, T.T.
登録日2019-02-13
公開日2019-07-03
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.221 Å)
主引用文献Structural insights into DNA recognition by AimR of the arbitrium communication system in the SPbeta phage.
Cell Discov, 5, 2019
3SQ4
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BU of 3sq4 by Molmil
RB69 DNA Polymerase Ternary Complex with dTTP Opposite 2AP (GC rich sequence)
分子名称: 5'-D(*CP*GP*CP*GP*CP*GP*GP*CP*GP*GP*CP*GP*(2DA))-3', 5'-D(P*CP*(2PR)P*TP*CP*GP*CP*CP*GP*CP*CP*GP*CP*GP*CP*GP*G)-3', CALCIUM ION, ...
著者Xia, S, Konigsberg, W.H, Wang, J.
登録日2011-07-04
公開日2011-11-09
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献Structure of the 2-Aminopurine-Cytosine Base Pair Formed in the Polymerase Active Site of the RB69 Y567A-DNA Polymerase.
Biochemistry, 50, 2011
3SUQ
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RB69 DNA Polymerase (Y567A) Ternary Complex with dCTP Opposite 2AP (AT rich sequence)
分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*AP*AP*TP*TP*AP*AP*TP*TP*AP*AP*TP*TP*(2DA))-3', 5'-D(P*CP*(2PR)P*TP*AP*AP*TP*TP*AP*AP*TP*TP*AP*AP*TP*TP*G)-3', ...
著者Xia, S, Konigsberg, W.H, Wang, J.
登録日2011-07-11
公開日2011-11-09
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Structure of the 2-Aminopurine-Cytosine Base Pair Formed in the Polymerase Active Site of the RB69 Y567A-DNA Polymerase.
Biochemistry, 50, 2011
8T7I
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Structure of the S1CE variant of Fab F1 (FabS1CE-F1)
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, S1CE variant of Fab F1 heavy chain, ...
著者Singer, A.U, Bruce, H.A, Enderle, L, Blazer, L, Adams, J.J, Sicheri, F, Sidhu, S.S.
登録日2023-06-20
公開日2023-11-22
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes.
Protein Sci., 33, 2024

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