3E87

Crystal structures of the kinase domain of AKT2 in complex with ATP-competitive inhibitors

Summary for 3E87

Entry DOI	10.2210/pdb3e87/pdb
Related	3E88 3E8C 3E8D 3E8E
Descriptor	RAC-beta serine/threonine-protein kinase, Glycogen synthase kinase-3 beta peptide, N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide, ... (4 entities in total)
Functional Keywords	akt2, kinase, gsk3 beta, atp-binding, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, wnt signaling pathway
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm: P31751 P49841
Total number of polymer chains	4
Total formula weight	81116.36
Authors	Concha, N.O.,Elkins, P.A.,Smallwood, A.,Ward, P. (deposition date: 2008-08-19, release date: 2008-10-14, Last modification date: 2021-10-20)
Primary citation	Rouse, M.B.,Seefeld, M.A.,Leber, J.D.,McNulty, K.C.,Sun, L.,Miller, W.H.,Zhang, S.,Minthorn, E.A.,Concha, N.O.,Choudhry, A.E.,Schaber, M.D.,Heerding, D.A. Aminofurazans as potent inhibitors of AKT kinase Bioorg.Med.Chem.Lett., 19:1508-1511, 2009 Cited by PubMed: 19179070 DOI: 10.1016/j.bmcl.2009.01.002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation