3E8C
Crystal structures of the kinase domain of PKA in complex with ATP-competitive inhibitors
Summary for 3E8C
Entry DOI | 10.2210/pdb3e8c/pdb |
Related | 3E87 3E88 3E8D 3E8E |
Descriptor | cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor peptide, 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-6-{[(2R)-2-amino-3-phenylpropyl]oxy}-1-ethyl-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol, ... (4 entities in total) |
Functional Keywords | pka, akt2, kinase, pki, bovine, inhibitor, atp-binding, camp, lipoprotein, myristate, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase, protein kinase inhibitor |
Biological source | Bos taurus (cow) More |
Cellular location | Cytoplasm : P00517 |
Total number of polymer chains | 12 |
Total formula weight | 260845.93 |
Authors | Concha, N.O.,Elkins, P.A.,Smallwood, A.,Ward, P. (deposition date: 2008-08-19, release date: 2008-11-18, Last modification date: 2017-10-25) |
Primary citation | Rouse, M.B.,Seefeld, M.A.,Leber, J.D.,McNulty, K.C.,Sun, L.,Miller, W.H.,Zhang, S.,Minthorn, E.A.,Concha, N.O.,Choudhry, A.E.,Schaber, M.D.,Heerding, D.A. Aminofurazans as potent inhibitors of AKT kinase Bioorg.Med.Chem.Lett., 19:1508-1511, 2009 Cited by PubMed: 19179070DOI: 10.1016/j.bmcl.2009.01.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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