3E8C
Crystal structures of the kinase domain of PKA in complex with ATP-competitive inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | cAMP-dependent protein kinase catalytic subunit alpha | polymer | 350 | 40786.4 | 6 | UniProt (P00517) Pfam (PF00069) | Bos taurus (cow) | PKA C-alpha |
| 2 | G, H, I, J, K... (G, H, I, J, K...) | cAMP-dependent protein kinase inhibitor peptide | polymer | 20 | 2226.4 | 6 | UniProt (Q3SX13) | PKI-alpha, PKI inhibitor peptide | |
| 3 | M, N, O, P, Q... (A, B, C, D, E...) | 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-6-{[(2R)-2-amino-3-phenylpropyl]oxy}-1-ethyl-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol | non-polymer | 461.5 | 6 | Chemie (G96) | |||
| 4 | AA, BA, CA, DA, S... (I, J, K, L, A...) | water | water | 18.0 | 762 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 258076.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2769.1 | |
| All* | Total formula weight | 260845.9 |
